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  • 没食子酰芍药苷

    Galloylpaeoniflorin

    没食子酰芍药苷
    产品编号 CFN90831
    CAS编号 122965-41-7
    分子式 = 分子量 C30H32O15 = 632.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 The roots of Paeonia lactiflora Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    没食子酰芍药苷 CFN90831 122965-41-7 1mg QQ客服:1413575084
    没食子酰芍药苷 CFN90831 122965-41-7 5mg QQ客服:1413575084
    没食子酰芍药苷 CFN90831 122965-41-7 10mg QQ客服:1413575084
    没食子酰芍药苷 CFN90831 122965-41-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • University of Melbourne (Australia)
  • Northeast Normal University Changchun (China)
  • Biotech R&D Institute (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Kyushu University (Japan)
  • University of Liège (Belgium)
  • Texas A&M University (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Medizinische Universit?t Wien (Austria)
  • University of Medicine and Pharmacy (Romania)
  • Pennsylvania State University (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2018, 13(3):e0193386
  • Front. Physiol.2022, 790345.
  • Applied Biological Chemistry2021, 64(4)
  • Molecules.2016, 21(6)
  • Int J Mol Sci.2020, 21(19),7070.
  • Int J Mol Sci.2020, 21(9):3239.
  • Biomed Pharmacother.2022, 146:112497.
  • BMC Complement Altern Med.2019, 19(1):339
  • International J of Green Pharmacy2019, 13(3)
  • Universite de Bordeaux2017, 2017BORD0867
  • J-STAGE2015, 249-255
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Phytomedicine.2017, 24:77-86
  • Int J Mol Sci.2020, 21(9):3392.
  • ACS Omega.2022, 7(44):40009-40020.
  • Plants (Basel).2021, 10(2):278.
  • Sci Rep. 2018, 10590
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Sci Rep.2018, 8(1)
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • J Ethnopharmacol.2016, 192:370-381
  • Life Sci.2019, 216:259-270
  • Nat Prod Communications2018, 10.1177
  • ...
  • 生物活性
    Description: Galloylpaeoniflorin exhibits anticomplement effects, it reveals a more pronounced radical scavenging effect than a-tocopherol. Galloylpaeoniflorin can take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation. Galloylpaeoniflorin exhibits good activity on acute lung injury.
    Targets: PAFR
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4389-93.
    Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury.[Pubmed: 25850273]
    This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method.
    METHODS AND RESULTS:
    The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship.
    CONCLUSIONS:
    Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, galloylpaeoniflorin and paeonol were the main effective components.
    J Nat Prod. 2014 Jan 24;77(1):42-8.
    Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.[Pubmed: 24377852 ]
    Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa.
    METHODS AND RESULTS:
    The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.
    Pharmazie. 2010 Aug;65(8):624-8.
    Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa.[Pubmed: 20824965]
    The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively.
    METHODS AND RESULTS:
    Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation. Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), paeoniflorigenone (8), galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
    Evid Based Complement Alternat Med . 2019 Mar 3;2019:6150357.
    The Screening Research of NF- κ B Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS[Pubmed: 30941197]
    Abstract Inflammation is a common and important pathological process, and nuclear factor-κB (NF-κB) is a key mediator of it. Moutan Cortex (MC), the dried root cortex of Paeonia suffruticosa Andr., is widely used as a remedy for the treatment of inflammatory diseases in Asian region. However, there are few studies on the systematic identification of NF-κB inhibitors of MC. In this study, the effect of inhibiting NF-κB activation of MC was assessed at the cellular level using a tumor necrosis factor-α (TNF-α) induced inflammatory model. Subsequently, ultra-performance liquid chromatography-quadrupole/time of flight-mass spectrometry (UPLC-Q/TOF-MS) combined with biological activity assay was established to screen and identify potential anti-inflammatory ingredients in MC. The results revealed that MC significantly inhibited the activation of NF-κB. Seven potential NF-κB inhibitors were screened from MC, including oxypaeoniflorin, paeoniflorin, galloylpaeoniflorin, benzoyloxypaeoniflorin, mudanpioside C, gallic acid, and paeonol. Among them, the NF-κB inhibitor activity of galloylpaeoniflorin, benzoyloxypaeoniflorin, and mudanpioside C is first reported here. In conclusion, the anti-inflammatory activity of MC was associated with the seven components mentioned above. And the bioactivity-integrated UPLC-Q/TOF which contains both chemical and bioactive details is suitable for screening active ingredients from natural medicines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5808 mL 7.9039 mL 15.8078 mL 31.6156 mL 39.5194 mL
    5 mM 0.3162 mL 1.5808 mL 3.1616 mL 6.3231 mL 7.9039 mL
    10 mM 0.1581 mL 0.7904 mL 1.5808 mL 3.1616 mL 3.9519 mL
    50 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
    100 mM 0.0158 mL 0.079 mL 0.1581 mL 0.3162 mL 0.3952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氧化芍药苷; Oxypaeoniflorin CFN99589 39011-91-1 C23H28O12 = 496.46 20mg QQ客服:2159513211
    2'-O-苯甲酰基芍药甙; 2'-O-Benzoylpaeoniflorin CFN89529 1456598-64-3 C30H32O12 = 584.56 5mg QQ客服:1413575084
    苯甲酰芍药苷; Benzoylpaeoniflorin CFN99536 38642-49-8 C30H32O12 = 584.57 20mg QQ客服:2056216494
    苯甲酰氧化芍药苷; Benzoyloxypeoniflorin CFN90662 72896-40-3 C30H32O13 = 600.57 20mg QQ客服:2159513211
    牡丹皮苷C; Mudanpioside C CFN90661 172760-03-1 C30H32O13 = 600.57 20mg QQ客服:1457312923
    没食子酰芍药苷; Galloylpaeoniflorin CFN90831 122965-41-7 C30H32O15 = 632.6 10mg QQ客服:2056216494
    芍药苷元酮; Paeoniflorigenone CFN96022 80454-42-8 C17H18O6 = 318.3 5mg QQ客服:3257982914
    芍药内苷B; Paeonilactone B CFN96055 98751-78-1 C10H12O4 = 196.2 5mg QQ客服:215959384
    芍药内苷C; Paeonilactone C CFN96056 98751-77-0 C17H18O6 = 318.3 5mg QQ客服:1413575084
    芍药内苷A; Paeonilactone A CFN96059 98751-79-2 C10H14O4 = 198.2 5mg QQ客服:215959384

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