Info: Read More
  • 中药标准品生产商,产品定制服务
  • 芍药苷

    Paeoniflorin

    芍药苷
    产品编号 CFN99544
    CAS编号 23180-57-6
    分子式 = 分子量 C23H28O11 = 480.45
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Monoterpenoids
    植物来源 The roots of Paeonia lactiflora Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芍药苷 CFN99544 23180-57-6 10mg QQ客服:1413575084
    芍药苷 CFN99544 23180-57-6 20mg QQ客服:1413575084
    芍药苷 CFN99544 23180-57-6 50mg QQ客服:1413575084
    芍药苷 CFN99544 23180-57-6 100mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • Calcutta University (India)
  • Max-Planck-Insitut (Germany)
  • Universidad de La Salle (Mexico)
  • Monash University Sunway Campus (Malaysia)
  • University of the Basque Country (Spain)
  • Universidade Federal de Goias (UFG) (Brazil)
  • The Australian National University (Australia)
  • Center for protein Engineering (CIP) (Belgium)
  • Tohoku University (Japan)
  • Medical University of Gdansk (Poland)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Vienna (Austria)
  • University of Beira Interior (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biosci Rep.2020, 40(8):BSR20201219.
  • J Ethnopharmacol.2021, 267:113615.
  • Biomed Chromatogr.2020, e5021.
  • Front Chem.2022, 10:1048467.
  • PLoS One.2021, 16(9):e0257243.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • PLoS One.2018, 13(4):e0195642
  • Phytochemistry.2017, 141:162-170
  • J Appl Pharm Sci.2022, 12(04):044-053
  • Journal of Ginseng Research2021, 25 November
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Biosci Rep.2018, 38(4)
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Int J Mol Med.2019, 43(6):2516-2522
  • Life (Basel).2022, 12(10):1630.
  • Biomolecules.2020, 10(6):925.
  • Int J Mol Sci.2022, 23(23):14545.
  • JMSACL2023, 09.002
  • Oncol Rep.2016, 35(3):1356-64
  • Antioxidants (Basel).2022, 11(12):2411.
  • Antioxidants (Basel).2020, 9(11):1121.
  • ...
  • 生物活性
    Description: Paeoniflorin, a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases.
    Targets: TNF-α | IL Receptor | cAMP | TGF-β/Smad | PI3K | Akt | Bcl-2/Bax | Caspase | Beta Amyloid
    In vitro:
    Phytomedicine. 2014 Sep 15;21(10):1170-7.
    Inhibitory effect of paeoniflorin on methylglyoxal-mediated oxidative stress in osteoblastic MC3T3-E1 cells.[Pubmed: 24916708]
    Methylglyoxal (MG) has been suggested to be one major source of intracellular reactive carbonyl compounds. In the present study, the effect of Paeoniflorin on MG-induced cytotoxicity was investigated using osteoblastic MC3T3-E1 cells.
    METHODS AND RESULTS:
    Osteoblastic MC3T3-E1 cells were pre-incubated with Paeoniflorin before treatment with MG, and markers of oxidative damage and mitochondrial function were examined. Pretreatment of MC3T3-E1 cells with Paeoniflorin prevented the MG-induced cell death and formation of intracellular reactive oxygen species, cardiolipin peroxidation, and protein adduct in osteoblastic MC3T3-E1 cells. In addition, Paeoniflorin increased glutathione level and restored the activity of glyoxalase I to almost the control level. These findings suggest that Paeoniflorin provide a protective action against MG-induced cell damage by reducing oxidative stress and by increasing MG detoxification system. Pretreatment with Paeoniflorin prior to MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential dissipation and adenosine triphosphate loss. Additionally, the nitric oxide and nuclear respiratory factor 1 levels were significantly increased by Paeoniflorin, suggesting that Paeoniflorin may induce mitochondrial biogenesis. Paeoniflorin treatment decreased the levels of proinflammatory cytokines such as TNF-α and IL-6.
    CONCLUSIONS:
    These findings indicate that Paeoniflorin might exert its therapeutic effects via upregulation of glyoxalase system and mitochondrial function. Taken together, Paeoniflorin may prove to be an effective treatment for diabeteic osteopathy.
    In vivo:
    Int Immunopharmacol. 2007 May;7(5):662-73.
    Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis.[Pubmed: 17386414 ]
    Paeoniflorin (Pae), a monoterpene glucoside, is one of the main bioactive components of total glucosides of paeony (TGP) extracted from the root of Paeonia lactiflora. TGP has anti-inflammatory and immunoregulatory effects.
    METHODS AND RESULTS:
    In this study, we investigated the effects of Pae on inflammatory and immune responses to the mesenteric lymph node (MLN) lymphocytes and the mechanisms by which Pae regulates beta 2-adrenergic receptor (beta 2-AR) signal transduction in adjuvant arthritis (AA) rats. The onset of secondary arthritis in rats appeared around day 14 after injection of Freund's complete adjuvant (FCA). Remarkable secondary inflammatory response and lymphocytes proliferation were observed in AA rats, along with the decrease of anti-inflammatory cytokines interleukin (IL)-4 and transforming growth factor-beta 1 (TGF-beta 1) of MLN lymphocytes, and the increase of pro-inflammatory cytokine IL-2. The administration of Pae (50, 100 mg kg(-1), days 17-24) significantly diminished the secondary hind paw swelling and arthritis scores, reversed the changes of cytokines as discussed above, and further decreased the lowered proliferation of MLN lymphocytes in AA rats. In vitro, Pae restored the previously increased level of cAMP of MLN lymphocytes at the concentrations of 12.5, 62.5 and 312.5 mg l(-1). Meanwhile, Pae increased protein expressions of beta 2-AR and GRK2, and decreased that of beta-arrestin 1, 2 of MLN lymphocytes in AA rats.
    CONCLUSIONS:
    These results suggested that Pae might induce the Th1 cells immune tolerance, which then shift to Th2, Th3 cells mediated activities to take effect the anti-inflammatory and immunoregulatory effects. The mechanisms of Pae on beta 2-AR desensitization and beta 2-AR-AC-cAMP transmembrane signal transduction of MLN lymphocytes play crucial roles in pathogenesis of this disease.
    Planta Med. 1997 Aug;63(4):323-5.
    Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora.[Pubmed: 9270377 ]

    METHODS AND RESULTS:
    Paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of Paeonia lactiflora Pall. (Ranunculaceae). They produced a significant blood sugar lowering effect in streptozotocin-treated rats and had a maximum effect at 25 min after treatment. This hypoglycemic action was also observed in normoglycemic rats only at 1 mg/kg. The antihyperglycemic activity of 8-debenzoylpaeoniflorin seems lower than that of paeoniflorin. Plasma insulin was not changed in paeoniflorin-treated normoglycemic rats indicating an insulin-independent action. Also, this glucoside reduced the elevation of blood sugar in glucose challenged rats.
    CONCLUSIONS:
    Increase of glucose utilization by paeoniflorin can thus be considered. There are no previous data showing the hypoglycemic activity of paeoniflorin and/or 8-debenzoylpaeoniflorin in rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0814 mL 10.4069 mL 20.8138 mL 41.6276 mL 52.0346 mL
    5 mM 0.4163 mL 2.0814 mL 4.1628 mL 8.3255 mL 10.4069 mL
    10 mM 0.2081 mL 1.0407 mL 2.0814 mL 4.1628 mL 5.2035 mL
    50 mM 0.0416 mL 0.2081 mL 0.4163 mL 0.8326 mL 1.0407 mL
    100 mM 0.0208 mL 0.1041 mL 0.2081 mL 0.4163 mL 0.5203 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芍药苷元酮; Paeoniflorigenone CFN96022 80454-42-8 C17H18O6 = 318.3 5mg QQ客服:2159513211
    芍药内苷B; Paeonilactone B CFN96055 98751-78-1 C10H12O4 = 196.2 5mg QQ客服:215959384
    芍药内苷C; Paeonilactone C CFN96056 98751-77-0 C17H18O6 = 318.3 5mg QQ客服:2056216494
    芍药内苷A; Paeonilactone A CFN96059 98751-79-2 C10H14O4 = 198.2 5mg QQ客服:1457312923
    苯甲酰芍药内酯苷; Benzoylalbiflorin CFN91579 184103-78-4 C30H32O12 = 584.6 10mg QQ客服:1413575084
    芍药苷; Paeoniflorin CFN99544 23180-57-6 C23H28O11 = 480.45 20mg QQ客服:3257982914
    氧化芍药苷; Oxypaeoniflorin CFN99589 39011-91-1 C23H28O12 = 496.46 20mg QQ客服:2056216494
    2'-O-苯甲酰基芍药甙; 2'-O-Benzoylpaeoniflorin CFN89529 1456598-64-3 C30H32O12 = 584.56 5mg QQ客服:1413575084
    苯甲酰芍药苷; Benzoylpaeoniflorin CFN99536 38642-49-8 C30H32O12 = 584.57 20mg QQ客服:2056216494
    苯甲酰氧化芍药苷; Benzoyloxypeoniflorin CFN90662 72896-40-3 C30H32O13 = 600.57 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产