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  • 芍药苷元酮

    Paeoniflorigenone

    芍药苷元酮
    产品编号 CFN96022
    CAS编号 80454-42-8
    分子式 = 分子量 C17H18O6 = 318.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 The roots of Paeonia lactiflora Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芍药苷元酮 CFN96022 80454-42-8 1mg QQ客服:2056216494
    芍药苷元酮 CFN96022 80454-42-8 5mg QQ客服:2056216494
    芍药苷元酮 CFN96022 80454-42-8 10mg QQ客服:2056216494
    芍药苷元酮 CFN96022 80454-42-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
  • Seoul National University (Korea)
  • Chiang Mai University (Thailand)
  • National Hellenic Research Foundation (Greece)
  • Istanbul University (Turkey)
  • MTT Agrifood Research Finland (Finland)
  • Universite de Lille1 (France)
  • Universitas islam negeri Jakarta (Indonesia)
  • Max-Planck-Insitut (Germany)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Celltrion Chemical Research Institute (Korea)
  • Nanjing University of Chinese Medicine (China)
  • University of Canterbury (New Zealand)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol. 2020, 83:106403.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Pharm Biol.2021, 59(1):134-145.
  • Pharmacol Res.2022, 182:106346.
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Front Plant Sci.2022, 13:982771.
  • Journal of Apicultural Research2021, 60(1)
  • Int Immunopharmacol.2022, 106:108603.
  • Plants (Basel).2022, 11(21):2947.
  • Molecules2022, 27(12):3903.
  • Phytochemistry Letters2017, 449-455
  • Comput Biol Chem.2019, 83:107096
  • J Korean Med Obes Res.2023, 23:10-7
  • Front Pharmacol.2020, 11:566490.
  • Sci Rep.2017, 7:46299
  • BMC Complement Altern Med.2017, 17(1):393
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Life Sci.2022, 311(Pt A):121157.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Biomol Ther (Seoul).2019, 10.4062
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Nutr Res Pract2019, 13:e45
  • ...
  • 生物活性
    Description: Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.Paeoniflorigenone is cytotoxic and induces apoptosis selectively in the cancer cell lines. Paeoniflorigenone shows anti-inflammatory effects, it may take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
    Targets: NO | Caspase
    In vitro:
    Pharmazie. 2010 Aug;65(8):624-8.
    Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa.[Pubmed: 20824965]
    The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively.
    METHODS AND RESULTS:
    Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation.
    CONCLUSIONS:
    Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), paeoniflorigenone (8), galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
    Bioscience Biotechnology & Biochemistry, 2017 :1-8.
    Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex[Reference: WebLink]

    METHODS AND RESULTS:
    Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines.
    CONCLUSIONS:
    These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.
    In vivo:
    Pharmaceutical Society of Korea, 2012,56(1):20-25.
    Anti-inflammatory effect of paeoniflorigenone isolated from Paeoniae Radix.[Reference: WebLink]
    In Northeast Asia, Paeoniae Radix has been used in treatments of inflammation-causing diseases such as arthritis for many centuries. Paeoniflorin, one of the principle bioactive monoterpene glucosides from the paeony root, is reported to be mostly responsible for the effectiveness of the treatments. However, the anti-inflammatory effect of a monoterpene, Paeoniflorigenone (PFG) which partially has the moiety of paeoniflorin minus a glucose structure is unknown. Thus, the aim of this work was to investigate anti-inflammatory activity of PFG.
    METHODS AND RESULTS:
    For the investigation, PFG activity on the NO (nitric oxide) prodn. from LPS-stimulated macrophages, and the anti-inflammatory effect was tested in the animal model of septic arthritis caused by Candida albicans, a major etiol. agent for septic arthritis. For induction of the arthritis, mice were administered with an emulsion of C. albicans cell wall (CACW) mixed with Complete Freund's Adjuvant (CFA) via footpad-injection (Day 0); PFG at a dose of 0.5 or 1 mg/mouse (25 or 50 mg/kg of body-wt.) was given to the animals on Day 3, 6, and 9; footpads were scored for arthritis. Moreover, the PFG effect on proliferation of T-lymphocyte that causes aggravation of arthritis was addnl. tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1417 mL 15.7085 mL 31.4169 mL 62.8338 mL 78.5423 mL
    5 mM 0.6283 mL 3.1417 mL 6.2834 mL 12.5668 mL 15.7085 mL
    10 mM 0.3142 mL 1.5708 mL 3.1417 mL 6.2834 mL 7.8542 mL
    50 mM 0.0628 mL 0.3142 mL 0.6283 mL 1.2567 mL 1.5708 mL
    100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.6283 mL 0.7854 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2'-O-苯甲酰基芍药甙; 2'-O-Benzoylpaeoniflorin CFN89529 1456598-64-3 C30H32O12 = 584.56 5mg QQ客服:2056216494
    苯甲酰芍药苷; Benzoylpaeoniflorin CFN99536 38642-49-8 C30H32O12 = 584.57 20mg QQ客服:1413575084
    苯甲酰氧化芍药苷; Benzoyloxypeoniflorin CFN90662 72896-40-3 C30H32O13 = 600.57 20mg QQ客服:2056216494
    牡丹皮苷C; Mudanpioside C CFN90661 172760-03-1 C30H32O13 = 600.57 20mg QQ客服:1457312923
    没食子酰芍药苷; Galloylpaeoniflorin CFN90831 122965-41-7 C30H32O15 = 632.6 10mg QQ客服:1457312923
    芍药苷元酮; Paeoniflorigenone CFN96022 80454-42-8 C17H18O6 = 318.3 5mg QQ客服:2159513211
    芍药内苷B; Paeonilactone B CFN96055 98751-78-1 C10H12O4 = 196.2 5mg QQ客服:3257982914
    芍药内苷C; Paeonilactone C CFN96056 98751-77-0 C17H18O6 = 318.3 5mg QQ客服:2056216494
    芍药内苷A; Paeonilactone A CFN96059 98751-79-2 C10H14O4 = 198.2 5mg QQ客服:2056216494
    苯甲酰芍药内酯苷; Benzoylalbiflorin CFN91579 184103-78-4 C30H32O12 = 584.6 10mg QQ客服:215959384

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