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  • 2'-甲氧基肉桂醛

    o-Methoxycinnamaldehyde

    2'-甲氧基肉桂醛
    产品编号 CFN93299
    CAS编号 1504-74-1
    分子式 = 分子量 C10H10O2 = 162.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The barks of Cinnamomum cassia Presl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    2'-甲氧基肉桂醛 CFN93299 1504-74-1 10mg QQ客服:1457312923
    2'-甲氧基肉桂醛 CFN93299 1504-74-1 20mg QQ客服:1457312923
    2'-甲氧基肉桂醛 CFN93299 1504-74-1 50mg QQ客服:1457312923
    2'-甲氧基肉桂醛 CFN93299 1504-74-1 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kitasato University (Japan)
  • Donald Danforth Plant Science Center (USA)
  • Istanbul University (Turkey)
  • University of Queensland (Australia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • The Institute of Cancer Research (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytother Res.2022, 10.1002:ptr.7602.
  • J Clin Med.2022, 11(13):3662.
  • Molecules.2021, 26(19):6032.
  • Int J Mol Sci.2018, 19(9):E2681
  • Molecules.2020, 25(21):5091.
  • Korean J of Crop Science2019, 452-458
  • JEJU National University2022, 10478.
  • Biomed Pharmacother.2021, 137:111362.
  • Cancers (Basel).2021, 13(6):1432.
  • Phytomedicine.2018, 47:48-57
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Food and Fermentation Industries2018, 44(371)
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Food and Chemical Toxicology2020, 111221
  • J Pharm Anal.2016, 6(6):363-373
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Front Microbiol.2020, 11:583594.
  • Sci Rep. 2017, 12953(7)
  • Anal Biochem.2019, 569:10-15
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • US20170000760 A12016, 42740
  • Fitoterapia.2022, 157:105130.
  • ...
  • 生物活性
    Description: o-Methoxycinnamaldehyde from cinnamon has antibiotic activity, it is a competitive inhibitor against CYP1A2 while it was a mixed type inhibitor against CYP2E.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Eur J Cancer Prev . 2017 Jul;26(4):314-323.
    Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells[Pubmed: 27192048]
    Abstract Cinnamomum verum has been used as a Chinese herbal medication. We investigated the antiproliferative effect of 2-methoxycinnamaldehyde (2-MCA), a constituent of the cortex of the plant, and the molecular biomarkers associated with tumorigenesis in human lung squamous cell carcinoma NCI-H520 cells. The effects of 2-MCA on cell growth, cytotoxicity, apoptosis, and topoisomerase I and II activities in human lung squamous cell carcinoma NCI-H520 cells were evaluated in vitro and in vivo. The results showed that 2-MCA inhibited proliferation and induced apoptosis as implicated by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase 3 and caspase 9, as well as morphological characteristics of apoptosis. Furthermore, 2-MCA also induced lysosomal vacuolation with elevated volume of acidic compartment and cytotoxicity, and inhibited topoisomerase I as well as II activities. Additional study showed the antiproliferative effect of 2-MCA in a nude mice model. In short, our data imply that the antiproliferative activity of 2-MCA in vitro involved downregulation of cell growth markers, both topoisomerase I and II, and upregulation of proapoptotic molecules, associated with increased lysosomal vacuolation. In vivo, 2-MCA reduced the tumor size, which could have had a significant clinical impact. Our data imply that 2-MCA may be a potential agent for chemoprevention as well as anticancer therapy.
    Int J Mol Med . 2017 Jan;39(1):191-198.
    2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells[Pubmed: 27922672]
    Abstract The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a crucial event in the development of atherosclerosis, and tumor necrosis factor-α (TNF-α) is actively involved in this process by enhancing the proliferation and migration of VSMCs. 2-Methoxycinnamaldehyde (MCA) is a natural compound of Cinnamomum cassia. Although 2-hydroxycinnamaldehyde (HCA), another compound from Cinnamomum cassia, has been widely studied with regard to its antitumor activity, MCA has not attracted researchers' interest due to its mild toxic effects on cancer cells and its mechanisms of action remain unknown. In this study, we examined the effects of MCA on the TNF-α-induced proliferation and migration of human aortic smooth muscle cells (HASMCs). As shown by our results, MCA inhibited TNF-α-induced cell proliferation by reducing the levels of cyclin D1, cyclin D3, CDK4 and CDK6, and increasing the levels of the cyclin-dependent kinase inhibitors, p21 and p27, without resulting in cellular cytotoxicity. Furthermore, MCA decreased the level of secreted matrix metalloproteinase (MMP)-9 by inhibiting MMP-9 transcription. Unexpectedly, MCA did not affect the TNF-α-induced levels of mitogen-activated protein kinases (MAPKs). However, by showing that MCA potently inhibited the degradation of IκBα and the subsequent nuclear translocation of nuclear factor-κB (NF-κB), we demonstrated that MCA exerts its effects through the NF-κB signaling pathway. MCA also effectively inhibited platelet-derived growth factor (PDGF)-induced HASMC migration. Taken together, these observations suggest that MCA has the potential for use as an anti-atherosclerotic agent.
    In vivo:
    Xenobiotica. 1986 Sep;16(9):845-52.
    Metabolism of the cinnamon constituent o-methoxycinnamaldehyde in the rat.[Pubmed: 3765663]

    METHODS AND RESULTS:
    The metabolism of o-methoxycinnamaldehyde (1.3 mmol/kg, intragastrically) was studied in rats. Identification of the urinary metabolites by g.l.c.-mass spectrometry and quantification by h.p.l.c. showed that the major metabolic pathway (approx. two-thirds of the dose) was oxidation to the corresponding cinnamic and phenylpropionic acids (C6-C3 acids) which were largely excreted as glycine conjugates. Intermediate amounts (approx. 10% of the dose) of the O-demethylated C6-C3 acids were excreted. Relatively large amounts of the beta-hydroxylated phenylpropionic acid derivative were found, however only traces of the further products of beta-oxidation (2-methoxylated derivatives of benzoic and hippuric acid) were excreted.
    CONCLUSIONS:
    No evidence was obtained for conjugation of o-methoxycinnamaldehyde with glutathione. Urinary excretion of metabolites was rapid (91% in 24 h and 98% in 48 h).
    Phytother Res . 2016 Feb;30(2):331-40.
    Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo[Pubmed: 26676220]
    Abstract Cinnamomum verum is used to make the spice cinnamon and has been used as a traditional Chinese herbal medicine. We evaluated the anticancer effect of 2-methoxycinnamaldehyde (2-MCA), a constituent of the bark of the plant, and its underlying molecular biomarkers associated with carcinogenesis in human lung adenocarcinoma A549 cells. The results show that 2-MCA suppressed proliferation and induced apoptosis as indicated by an upregulation of pro-apoptotic Bax and Bak genes and downregulation of anti-apoptotic Bcl-2 and Bcl-XL genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase-3 and -9, and morphological characteristics of apoptosis, including plasma membrane blebbing and long comet tail. In addition, 2-MCA also induced lysosomal vacuolation with increased volume of acidic compartment (VAC) and suppressions of nuclear transcription factors nuclear factor-κB (NF-κB) and both topoisomerase I and II activities. Further study reveals that the growth-inhibitory effect of 2-MCA was also evident in a nude mice model. Taken together, the data suggest that the growth-inhibitory effect of 2-MCA against A549 cells is accompanied by downregulations of NF-κB binding activity and proliferative control involving apoptosis and both topoisomerase I and II activities, together with an upregulation of lysosomal vacuolation and VAC. Our data suggest that 2-MCA could be a potential agent for anticancer therapy. Keywords: 2-methoxycinnamaldehyde; A549 cells; anticancer; topoisomerase I; topoisomerase II.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.1652 mL 30.8261 mL 61.6523 mL 123.3046 mL 154.1307 mL
    5 mM 1.233 mL 6.1652 mL 12.3305 mL 24.6609 mL 30.8261 mL
    10 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
    50 mM 0.1233 mL 0.6165 mL 1.233 mL 2.4661 mL 3.0826 mL
    100 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    肉桂醛; Cinnamaldehyde CFN99478 104-55-2 C9H8O = 132.2 20mg QQ客服:3257982914
    3-(2-羟基苯基)-2-丙烯醛; 3-(2-Hydroxyphenyl)-2-propenal CFN97017 60125-23-7 C9H8O2 = 148.2 5mg QQ客服:215959384
    2'-甲氧基肉桂醛; o-Methoxycinnamaldehyde CFN93299 1504-74-1 C10H10O2 = 162.2 20mg QQ客服:2159513211
    4-甲氧基肉桂醛; 4-Methoxycinnamaldehyde CFN90559 1963-36-6 C10H10O2 = 162.19 20mg QQ客服:3257982914
    松柏醛; Coniferaldehyde CFN98037 20649-42-7 C10H10O3 = 178.2 5mg QQ客服:3257982914
    芥子醛; Sinapaldehyde CFN98038 20649-43-8 C11H12O4 = 208.2 10mg QQ客服:3257982914
    3-甲氧基-4,5-亚甲基二氧基肉桂醛; 3-Methoxy-4,5-methylenedioxycinnamaldehyde CFN97228 74683-19-5 C11H10O4 = 206.2 5mg QQ客服:2159513211

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