芥子醛

Sinapaldehyde

	产品编号	CFN98038
	CAS编号	20649-43-8
	分子式 = 分子量	C₁₁H₁₂O₄ = 208.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The heart woods of Populus tomentosa
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产品名称	产品编号	CAS编号	包装	QQ客服
芥子醛	CFN98038	20649-43-8	1mg	QQ客服：2159513211
芥子醛	CFN98038	20649-43-8	5mg	QQ客服：2159513211
芥子醛	CFN98038	20649-43-8	10mg	QQ客服：2159513211
芥子醛	CFN98038	20649-43-8	20mg	QQ客服：2159513211

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Description:

Sinapaldehyde has effects against 65 strains of Candida,Sinapaldehyde inhibits prostaglandin synthetase in a dose-dependent way, it dose-dependently inhibits ethyl phenylpropiolate-induced edema of the rat ear, and can inhibit electrically induced contractions of the guinea pig ileum in a dose-dependent way.The reaction of sinapaldehyde and methylpyranoanthocyanin can obtain a new bluish pigment.

Targets:

Antifection | PGE

In vitro:

J Med Microbiol. 2013 Feb;62(Pt 2):232-40.

Influences of cinnamic aldehydes on H⁺ extrusion activity and ultrastructure of Candida.[Pubmed: 22034160 ]

METHODS AND RESULTS:
The antifungal effects of cinnamaldehyde, 4-hydroxy-3-methoxycinnamaldehyde (coniferyl aldehyde) and 3,5-dimethoxy-4-hydroxycinnamaldehyde (sinapaldehyde) were investigated against 65 strains of Candida (six standard, 39 fluconazole-sensitive and 20 fluconazole-resistant). MICs of cinnamaldehyde, coniferyl aldehyde and sinapaldehyde ranged from 100 to 500 µg ml(-1), 100 to 300 µg ml(-1) and 100 to 200 µg ml(-1), respectively. All tested isolates showed a marked sensitivity towards these aldehydes in spot and time-kill assays. Sinapaldehyde was found to be the most effective, followed by coniferyl aldehyde and cinnamaldehyde. At their respective MIC(90) values, the three compounds caused mean inhibition levels of glucose-stimulated H(+)-efflux of 36, 34 and 41 % (cinnamaldehyde), 41, 42 and 47 % (coniferyl aldehyde) and 43, 45 and 51 % (sinapaldehyde) for standard-sensitive, clinical-sensitive and clinical-resistant isolates, respectively. Inhibition levels of H(+)-efflux caused by plasma membrane ATPase inhibitors N,N'-dicyclohexylcarbodiimide (100 µM) and diethylstilbestrol (10 µM) were 34, 45 and 44 %, and 57, 39 and 35 %, for standard-sensitive, clinical-sensitive and clinical-resistant isolates, respectively. Intracellular pH (pHi) was found to decrease by 0.34, 0.42 and 0.50 units following incubation with three tested aldehydes from the control pHi of 6.70. Scanning electron microscopy and transmission electron microscopy analysis was performed on a representative strain, C. albicans 10261, showing alterations in morphology, cell wall, plasma membrane damage and lysis. Haemolytic activity of the three compounds varied from 10 to 15 % at their highest MIC compared to an activity level of 20 % shown by fluconazole at 30 µg ml(-1).
CONCLUSIONS:
In conclusion, this study shows significant activity of cinnamic aldehydes against Candida, including azole-resistant strains, suggesting that these molecules can be developed as antifungals.

In vivo:

Planta Med. 1992 Feb;58(1):14-8.

Pharmacologically active phenylpropanoids from Senra incana.[Pubmed: 1620737 ]

Coniferaldehyde, scopoletin, Sinapaldehyde, and syringaldehyde were isolated from an aqueous extract of Senra incana.
METHODS AND RESULTS:
All four compounds inhibited prostaglandin synthetase in a dose-dependent way. Compared to aspirin, the potency of coniferaldehyde and scopoletin was about five times higher, whereas syringaldehyde and Sinapaldehyde had about half the potency of this reference compound. On topical application, Sinapaldehyde and scopoletin dose-dependently inhibited ethyl phenylpropiolate-induced edema of the rat ear. The active dose range was 1-10 micrograms/ear. Higher doses had a lower effect.
CONCLUSIONS:
Syringaldehyde was active in the range 20-100 micrograms/ear, whereas the effect of coniferaldehyde was inconclusive. Coniferaldehyde and Sinapaldehyde inhibited electrically induced contractions of the guinea pig ileum in a dose-dependent way. Syringaldehyde showed a weak inhibition at a concentration of 550 microM.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
肉桂醛; Cinnamaldehyde	CFN99478	104-55-2	C₉H₈O = 132.2	20mg	QQ客服：215959384
3-(2-羟基苯基)-2-丙烯醛; 3-(2-Hydroxyphenyl)-2-propenal	CFN97017	60125-23-7	C₉H₈O₂ = 148.2	5mg	QQ客服：1457312923
2'-甲氧基肉桂醛; o-Methoxycinnamaldehyde	CFN93299	1504-74-1	C₁₀H₁₀O₂ = 162.2	20mg	QQ客服：215959384
4-甲氧基肉桂醛; 4-Methoxycinnamaldehyde	CFN90559	1963-36-6	C₁₀H₁₀O₂ = 162.19	20mg	QQ客服：2159513211
松柏醛; Coniferaldehyde	CFN98037	20649-42-7	C₁₀H₁₀O₃ = 178.2	5mg	QQ客服：215959384
芥子醛; Sinapaldehyde	CFN98038	20649-43-8	C₁₁H₁₂O₄ = 208.2	10mg	QQ客服：215959384
3-甲氧基-4,5-亚甲基二氧基肉桂醛; 3-Methoxy-4,5-methylenedioxycinnamaldehyde	CFN97228	74683-19-5	C₁₁H₁₀O₄ = 206.2	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8031 mL	24.0154 mL	48.0307 mL	96.0615 mL	120.0768 mL
5 mM	0.9606 mL	4.8031 mL	9.6061 mL	19.2123 mL	24.0154 mL
10 mM	0.4803 mL	2.4015 mL	4.8031 mL	9.6061 mL	12.0077 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	1.9212 mL	2.4015 mL
100 mM	0.048 mL	0.2402 mL	0.4803 mL	0.9606 mL	1.2008 mL

芥子醛

Sinapaldehyde

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