花姜酮

Zerumbone

	产品编号	CFN91066
	CAS编号	471-05-6
	分子式 = 分子量	C₁₅H₂₂O = 218.3
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Zingiber officinale
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
花姜酮	CFN91066	471-05-6	10mg	QQ客服：2056216494
花姜酮	CFN91066	471-05-6	20mg	QQ客服：2056216494
花姜酮	CFN91066	471-05-6	50mg	QQ客服：2056216494
花姜酮	CFN91066	471-05-6	100mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

Zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. Zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells; it suppresses enterotoxigenic bacteroides fragilis infection-induced colonic inflammation through inhibition of NF-κΒ. Zerumbone exhibits a hepatoprotective effect against ALI through its antioxidant and anti-inflammatory activities and the possible mechanism might be mediated by the TLR4/NF-κB/COX-2 pathway. Zerumbone can be a potential candidate for development of immunosuppressive agent.

Targets:

NF-κB | TLR4 | COX | Notch-1 | Hes-1 | NOS | TNF-α | TLR

In vitro:

Microb Pathog. 2019 Oct 1;137:103768.

Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus.[Pubmed: 31585154 ]

Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related infections that are strongly resistant to antibiotics and host immune responses compared with mono-species biofilms. The purpose of this study was to describe the efficacy of zerumbone derived from Zingiber zerumbet (L.) Smith, on dual-species biofilm formation.
METHODS AND RESULTS:
This study examined the inhibitory effects of zerumbone on planktonic cell growth, adhesion and biofilm formation. The results demonstrated that zerumbone remarkably inhibited mono- and dual-species biofilms formed by C. albicans and S. aureus using the XTT [2,3-bis(2-smethoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. Furthermore, a significant decrease in biomass and cell density of dual-species biofilms following zerumbone treatment was confirmed using confocal laser scanning microscopy (CLSM).
CONCLUSIONS:
Therefore, our study suggests that zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus.

In vivo:

Folia Neuropathol. 2019;57(3):277-284.

Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling.[Pubmed: 31588714 ]

Present investigation determines the effect of zerumbone on the proliferation of stem cells in vascular dementia (VD) rats.
METHODS AND RESULTS:
Vascular dementia was induced by cerebral ischemia and reperfusion through non-invasive clamp. Rats were treated with zerumbone 50 mg/kg and 100 mg/kg intraperitoneally 30 min for four weeks after the surgery. Cognitive functions are determined by the Morris water maze (MWM) test and neurological function score in VD rats. Moreover mediators of inflammation and parameters of oxidative stress were estimated in the brain tissue homogenate of ischemia-induced vascular dementia rats. The expression of proteins and mRNA expressions were determined by western blot assay and RT-PCR methods. Moreover histopathological changes were observed by H&E staining on the brain tissue of vascular dementia rats. There was a significant reduction in the cognitive function and neurological score in the zerumbone-treated group compared to the VD group of rats. Data of the study reveal that treatment with zerumbone attenuates the altered level of cytokines and markers of oxidative stress parameters in the brain tissue of VD rats. The expression of NICD, Hes-1 and Nestin proteins was significantly (p < 0.01) reduced in the brain tissue of the zerumbone-treated group compared to the VD group of rats. There was a significant reduction in the mRNA expression of Notch-1 and Hes-1 in the brain tissue of the zerumbone-treated group compared to the VD group of rats.
CONCLUSIONS:
This study concludes that treatment with zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells. Moreover proliferation of neural stem cells was stimulated in zerumbone-treated rats by regulating the Notch signalling.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
反式石竹烯; trans-Caryophyllene	CFN90502	87-44-5	C₁₅H₂₄ = 204.36	20mg	QQ客服：215959384
石竹素; Caryophyllene oxide	CFN99239	1139-30-6	C₁₅H₂₄O = 220.4	20mg	QQ客服：3257982914
可布酮; Kobusone	CFN98253	24173-71-5	C₁₄H₂₂O₂ = 222.3	5mg	QQ客服：215959384
α-石竹烯; Alpha-caryophyllene	CFN93582	6753-98-6	C₁₅H₂₄ = 204.4	20mg	QQ客服：1457312923
花姜酮; Zerumbone	CFN91066	471-05-6	C₁₅H₂₂O = 218.3	20mg	QQ客服：1457312923
环氧化蛇麻烯II; Humulene epoxide II	CFN98008	19888-34-7	C₁₅H₂₄O = 220.4	5mg	QQ客服：2159513211
十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide	CFN99039	102227-61-2	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：215959384
大牛儿烯 D; Germacrene D	CFN93281	37839-63-7	C₁₅H₂₄ = 204.4	5mg	QQ客服：1457312923
环十五烷酮; Cyclopentadecanone	CFN93169	502-72-7	C₁₅H₂₈O = 224.4	20mg	QQ客服：2056216494
麝香酮; Muscone	CFN99518	541-91-3	C₁₆H₃₀O = 238.42	20mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5809 mL	22.9043 mL	45.8085 mL	91.617 mL	114.5213 mL
5 mM	0.9162 mL	4.5809 mL	9.1617 mL	18.3234 mL	22.9043 mL
10 mM	0.4581 mL	2.2904 mL	4.5809 mL	9.1617 mL	11.4521 mL
50 mM	0.0916 mL	0.4581 mL	0.9162 mL	1.8323 mL	2.2904 mL
100 mM	0.0458 mL	0.229 mL	0.4581 mL	0.9162 mL	1.1452 mL

花姜酮

Zerumbone

信息支持

联系方式