花姜酮

Zerumbone

	产品编号	CFN91066
	CAS编号	471-05-6
	分子式 = 分子量	C₁₅H₂₂O = 218.3
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Zingiber officinale
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产品名称	产品编号	CAS编号	包装	QQ客服
花姜酮	CFN91066	471-05-6	10mg	QQ客服：1413575084
花姜酮	CFN91066	471-05-6	20mg	QQ客服：1413575084
花姜酮	CFN91066	471-05-6	50mg	QQ客服：1413575084
花姜酮	CFN91066	471-05-6	100mg	QQ客服：1413575084

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Description:

Zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. Zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells; it suppresses enterotoxigenic bacteroides fragilis infection-induced colonic inflammation through inhibition of NF-κΒ. Zerumbone exhibits a hepatoprotective effect against ALI through its antioxidant and anti-inflammatory activities and the possible mechanism might be mediated by the TLR4/NF-κB/COX-2 pathway. Zerumbone can be a potential candidate for development of immunosuppressive agent.

Targets:

NF-κB | TLR4 | COX | Notch-1 | Hes-1 | NOS | TNF-α | TLR

In vitro:

Microb Pathog. 2019 Oct 1;137:103768.

Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus.[Pubmed: 31585154 ]

Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related infections that are strongly resistant to antibiotics and host immune responses compared with mono-species biofilms. The purpose of this study was to describe the efficacy of zerumbone derived from Zingiber zerumbet (L.) Smith, on dual-species biofilm formation.
METHODS AND RESULTS:
This study examined the inhibitory effects of zerumbone on planktonic cell growth, adhesion and biofilm formation. The results demonstrated that zerumbone remarkably inhibited mono- and dual-species biofilms formed by C. albicans and S. aureus using the XTT [2,3-bis(2-smethoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. Furthermore, a significant decrease in biomass and cell density of dual-species biofilms following zerumbone treatment was confirmed using confocal laser scanning microscopy (CLSM).
CONCLUSIONS:
Therefore, our study suggests that zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus.

In vivo:

Folia Neuropathol. 2019;57(3):277-284.

Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling.[Pubmed: 31588714 ]

Present investigation determines the effect of zerumbone on the proliferation of stem cells in vascular dementia (VD) rats.
METHODS AND RESULTS:
Vascular dementia was induced by cerebral ischemia and reperfusion through non-invasive clamp. Rats were treated with zerumbone 50 mg/kg and 100 mg/kg intraperitoneally 30 min for four weeks after the surgery. Cognitive functions are determined by the Morris water maze (MWM) test and neurological function score in VD rats. Moreover mediators of inflammation and parameters of oxidative stress were estimated in the brain tissue homogenate of ischemia-induced vascular dementia rats. The expression of proteins and mRNA expressions were determined by western blot assay and RT-PCR methods. Moreover histopathological changes were observed by H&E staining on the brain tissue of vascular dementia rats. There was a significant reduction in the cognitive function and neurological score in the zerumbone-treated group compared to the VD group of rats. Data of the study reveal that treatment with zerumbone attenuates the altered level of cytokines and markers of oxidative stress parameters in the brain tissue of VD rats. The expression of NICD, Hes-1 and Nestin proteins was significantly (p < 0.01) reduced in the brain tissue of the zerumbone-treated group compared to the VD group of rats. There was a significant reduction in the mRNA expression of Notch-1 and Hes-1 in the brain tissue of the zerumbone-treated group compared to the VD group of rats.
CONCLUSIONS:
This study concludes that treatment with zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells. Moreover proliferation of neural stem cells was stimulated in zerumbone-treated rats by regulating the Notch signalling.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
反式石竹烯; trans-Caryophyllene	CFN90502	87-44-5	C₁₅H₂₄ = 204.36	20mg	QQ客服：1457312923
石竹素; Caryophyllene oxide	CFN99239	1139-30-6	C₁₅H₂₄O = 220.4	20mg	QQ客服：3257982914
可布酮; Kobusone	CFN98253	24173-71-5	C₁₄H₂₂O₂ = 222.3	5mg	QQ客服：2056216494
α-石竹烯; Alpha-caryophyllene	CFN93582	6753-98-6	C₁₅H₂₄ = 204.4	20mg	QQ客服：2159513211
花姜酮; Zerumbone	CFN91066	471-05-6	C₁₅H₂₂O = 218.3	20mg	QQ客服：1457312923
环氧化蛇麻烯II; Humulene epoxide II	CFN98008	19888-34-7	C₁₅H₂₄O = 220.4	5mg	QQ客服：215959384
十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide	CFN99039	102227-61-2	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：1457312923
大牛儿烯 D; Germacrene D	CFN93281	37839-63-7	C₁₅H₂₄ = 204.4	5mg	QQ客服：2056216494
环十五烷酮; Cyclopentadecanone	CFN93169	502-72-7	C₁₅H₂₈O = 224.4	20mg	QQ客服：1457312923
麝香酮; Muscone	CFN99518	541-91-3	C₁₆H₃₀O = 238.42	20mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5809 mL	22.9043 mL	45.8085 mL	91.617 mL	114.5213 mL
5 mM	0.9162 mL	4.5809 mL	9.1617 mL	18.3234 mL	22.9043 mL
10 mM	0.4581 mL	2.2904 mL	4.5809 mL	9.1617 mL	11.4521 mL
50 mM	0.0916 mL	0.4581 mL	0.9162 mL	1.8323 mL	2.2904 mL
100 mM	0.0458 mL	0.229 mL	0.4581 mL	0.9162 mL	1.1452 mL

花姜酮

Zerumbone

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