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  • 石竹素

    Caryophyllene oxide

    石竹素
    产品编号 CFN99239
    CAS编号 1139-30-6
    分子式 = 分子量 C15H24O = 220.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The fruits of Eugenia caryophyllata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    石竹素 CFN99239 1139-30-6 10mg QQ客服:1413575084
    石竹素 CFN99239 1139-30-6 20mg QQ客服:1413575084
    石竹素 CFN99239 1139-30-6 50mg QQ客服:1413575084
    石竹素 CFN99239 1139-30-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Michigan State University (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Hull (United Kingdom)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Biotech R&D Institute (USA)
  • Hamdard University (India)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Georgia Institute of Technology (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Hertfordshire (United Kingdom)
  • Universidad Miguel Hernández (Spain)
  • Pennsylvania State University (USA)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Processes2021, 9(5),831.
  • Front Pharmacol.2021, 12:635510.
  • Planta Med.2019, 85(9-10):766-773
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Front Pharmacol.2019, 10:1226
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Appl. Sci.2020, 10(23), 8729
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Plant Physiol Biochem.2019, 144:355-364
  • Cytotechnology2022, s10616
  • Int J Mol Sci.2019, 20(16):E4015
  • Lab Chip.2018, 18(6):971-978
  • Toxicological Research2020, doi: 10.1007.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Sci Rep. 2018, 1-9
  • Front Plant Sci.2022, 12:811166.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Srinagarind Medical Journal2019, 34(1)
  • The Journal of Supercritical Fluids2021, 176:105305.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Viruses2023, 15(6), 1377
  • BMC Complement Altern Med.2019, 19(1):339
  • ...
  • 生物活性
    Description: Caryophyllene oxide, an oxygenated terpenoid existed in many plant essential oil, is well known as preservative in food, drugs and cosmetics with antifungal, acaricidal, anti-inflammatory, anti-carcinogenic, significant central as well as peripheral analgesic and skin penetration enhancing properties. Caryophyllene Oxide and lupenone have synergistic effect against Trypanosoma cruzi. It inhibited growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways, ROS-mediated MAPKs activation, and via modulation of 15-LOX.
    Targets: PI3K | mTOR | Akt | ROS | p38MAPK | LOX
    In vitro:
    Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):45-55.
    Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells.[Pubmed: 24484210]
    Aegle marmelos (Indian Bael) is a tree which belongs to the family of Rutaceae. It holds a prominent position in both Indian medicine and Indian culture.
    METHODS AND RESULTS:
    We have screened various fractions of Aegle marmelos extracts for their anticancer properties using in vitro cell models. Gas chromatography-Mass spectrometry (GC-MS) was employed to analyze the biomolecules present in the Aegle marmelos extract. Jurkat and human neuroblastoma (IMR-32) cells were treated with different concentrations of the fractionated Aegle marmelos extracts. Flow cytometric analysis revealed that optimal concentration (50 μg/ml) of beta caryophyllene and caryophyllene oxide fractions of Aegle marmelos extract can induce apoptosis in Jurkat cell line. cDNA expression profiling of pro-apoptotic and anti-apoptotic genes was carried out using real time PCR (RT-PCR). Down-regulation of anti-apoptotic genes (bcl-2, mdm2, cox2 and cmyb) and up-regulation of pro-apoptotic genes (bax, bak1, caspase-8, caspase-9 and ATM) in Jurkat and IMR-32 cells treated with the beta caryophyllene and caryophyllene oxide fractions of Aegle marmelos extract revealed the insights of the downstream apoptotic mechanism. Furthermore, in-silico approach was employed to understand the upstream target involved in the induction of apoptosis by the beta caryophyllene and caryophyllene oxide fractions of Aegle marmelos extract.
    CONCLUSIONS:
    Herein, we report that beta caryophyllene and caryophyllene oxide isolated from Aegle marmelos can act as potent anti-inflammatory agents and modulators of a newly established therapeutic target, 15-lipoxygenase (15-LOX). Beta caryophyllene and caryophyllene oxide can induce apoptosis in lymphoma and neuroblastoma cells via modulation of 15-LOX (up-stream target) followed by the down-regulation of anti-apoptotic and up-regulation of pro-apoptotic genes.
    In vivo:
    Phytomedicine. 2010 Feb;17(2):149-51.
    Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark.[Pubmed: 19576741]
    Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity.
    METHODS AND RESULTS:
    Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity.
    CONCLUSIONS:
    These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.
    Cancer Lett. 2011 Dec 22;312(2):178-88
    β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.[Pubmed: 21924548]
    Both PI3K/AKT/mTOR/S6K1 and mitogen activated protein kinase (MAPK) signaling cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis of tumor cells.
    METHODS AND RESULTS:
    In the present report, we investigated the effects of β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oils of medicinal plants such as guava (Psidium guajava), oregano (Origanum vulgare L.), cinnamon (Cinnamomum spp.) clove (Eugenia caryophyllata), and black pepper (Piper nigrum L.) on the PI3K/AKT/mTOR/S6K1 and MAPK activation pathways in human prostate and breast cancer cells. We found that CPO not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 signaling cascade; but also caused the activation of ERK, JNK, and p38 MAPK in tumor cells. CPO induced increased reactive oxygen species (ROS) generation from mitochondria, which is associated with the induction of apoptosis as characterized by positive Annexin V binding and TUNEL staining, loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-3, and cleavage of PARP. Inhibition of ROS generation by N-acetylcysteine (NAC) significantly prevented CPO-induced apoptosis. Subsequently, CPO also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21. Interestingly, we also observed that CPO can significantly potentiate the apoptotic effects of various pharmacological PI3K/AKT inhibitors when employed in combination in tumor cells.
    CONCLUSIONS:
    Overall, these findings suggest that CPO can interfere with multiple signaling cascades involved in tumorigenesis and used as a potential therapeutic candidate for both the prevention and treatment of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
    5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
    10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
    50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
    100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式石竹烯; trans-Caryophyllene CFN90502 87-44-5 C15H24 = 204.36 20mg QQ客服:2159513211
    石竹素; Caryophyllene oxide CFN99239 1139-30-6 C15H24O = 220.4 20mg QQ客服:2056216494
    可布酮; Kobusone CFN98253 24173-71-5 C14H22O2 = 222.3 5mg QQ客服:3257982914
    α-石竹烯; Alpha-caryophyllene CFN93582 6753-98-6 C15H24 = 204.4 20mg QQ客服:2056216494
    花姜酮; Zerumbone CFN91066 471-05-6 C15H22O = 218.3 20mg QQ客服:3257982914
    环氧化蛇麻烯II; Humulene epoxide II CFN98008 19888-34-7 C15H24O = 220.4 5mg QQ客服:1457312923
    十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide CFN99039 102227-61-2 C15H22O3 = 250.3 5mg QQ客服:3257982914
    大牛儿烯 D; Germacrene D CFN93281 37839-63-7 C15H24 = 204.4 5mg QQ客服:215959384
    环十五烷酮; Cyclopentadecanone CFN93169 502-72-7 C15H28O = 224.4 20mg QQ客服:215959384
    麝香酮; Muscone CFN99518 541-91-3 C16H30O = 238.42 20mg QQ客服:2056216494

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