蓬莪术环氧酮

Zederone

	产品编号	CFN92616
	CAS编号	7727-79-9
	分子式 = 分子量	C₁₅H₁₈O₃ = 246.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The rhizomes of Curcuma zedoaria
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
蓬莪术环氧酮	CFN92616	7727-79-9	10mg	QQ客服：2056216494
蓬莪术环氧酮	CFN92616	7727-79-9	20mg	QQ客服：2056216494
蓬莪术环氧酮	CFN92616	7727-79-9	50mg	QQ客服：2056216494
蓬莪术环氧酮	CFN92616	7727-79-9	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Guangzhou Institutes of Biomedicine and Health (China)

Lund University (Sweden)

The University of Newcastle (Australia)

Gyeongsang National University (Korea)

Julius Kühn-Institut (Germany)

University of Limpopo (South Africa)

Texas A&M University (USA)

Universidad de Buenos Aires (Argentina)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

University of East Anglia (United Kingdom)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Monash University (Australia)

Michigan State University (USA)

Chinese University of Hong Kong (China)

More...

Description:

Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.

Targets:

TNF-α | Nrf2 | NADPH-oxidase | P450 (e.g. CYP17) | Antifection

In vivo:

Int J Toxicol. 2013 Nov-Dec;32(6):454-62.

Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice.[Pubmed: 24082031]

The present study aimed to investigate the hepatotoxicity of Zederone isolated from Curcuma elata in mice.
METHODS AND RESULTS:
Adult male mice were intraperitoneally injected with a single dose of Zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, Zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD₅₀) value at 24 hours of Zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased.
CONCLUSIONS:
The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of Zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one; (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one	CFN95219	1393342-06-7	C₁₆H₂₀O₃ = 260.3	5mg	QQ客服：215959384
乌药醚内酯; Linderane	CFN98175	13476-25-0	C₁₅H₁₆O₄ = 260.28	20mg	QQ客服：1413575084
伪新乌药醚内酯; Pseudoneolinderane	CFN91936	20082-45-5	C₁₅H₁₆O₄ = 260.29	5mg	QQ客服：1413575084
二氢焦蓬莪术酮; Dihydropyrocurzerenone	CFN91911	59462-26-9	C₁₅H₁₈O = 214.30	5mg	QQ客服：3257982914
焦蓬莪术酮; Pyrocurzerenone	CFN96169	20013-75-6	C₁₅H₁₆O = 212.3	20mg	QQ客服：1413575084
Dehydrochromolaenin; Dehydrochromolaenin	CFN96174	20013-76-7	C₁₅H₁₄O = 210.3	5mg	QQ客服：2056216494
2-Methoxyfuranoguaia-9-ene-8-one; 2-Methoxyfuranoguaia-9-ene-8-one	CFN95220	88010-62-2	C₁₆H₂₀O₃ = 260.3	10mg	QQ客服：1457312923
2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one; 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one	CFN95197	1809980-25-3	C₁₈H₂₄O₅ = 320.4	10mg	QQ客服：215959384
异莪术呋喃二烯; Isofuranodiene	CFN98971	57566-47-9	C₁₅H₂₀O = 216.3	5mg	QQ客服：1413575084
莪术呋喃二烯酮; Furanodienone	CFN92028	24268-41-5	C₁₅H₁₈O₂ = 230.3	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	81.2018 mL	101.5022 mL
5 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
10 mM	0.406 mL	2.03 mL	4.0601 mL	8.1202 mL	10.1502 mL
50 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL
100 mM	0.0406 mL	0.203 mL	0.406 mL	0.812 mL	1.015 mL