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  • 乌药醚内酯

    Linderane

    乌药醚内酯
    产品编号 CFN98175
    CAS编号 13476-25-0
    分子式 = 分子量 C15H16O4 = 260.28
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Lindera aggregata( Sims) Kosterm
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乌药醚内酯 CFN98175 13476-25-0 10mg QQ客服:1457312923
    乌药醚内酯 CFN98175 13476-25-0 20mg QQ客服:1457312923
    乌药醚内酯 CFN98175 13476-25-0 50mg QQ客服:1457312923
    乌药醚内酯 CFN98175 13476-25-0 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2023, 12(1):163.
  • J Biol Chem.2014, 289(3):1723-31
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Ann Transl Med.2019, 7(23):731
  • RSC Adv.2023, 13(9):6317-6326.
  • Horticulture Research2023, uhad164.
  • Journal of Functional Foods2019, 52:430-441
  • European Journal of Integrative Medicine2018, 20:165-172
  • Fitoterapia.2022, 157:105130.
  • Institute of Food Science & Technology2021, 45(9).
  • J of Apicultural Research2020, 10.1080
  • Plants (Basel).2022, 11(16):2126.
  • Cytotechnology2022, s10616
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Adaptive Medicine 2020, 12(1): 4-10
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • TCI CO.2019, US20190151281A1
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Molecules.2021, 26(4):817.
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Food Chem.2017, 228:301-314
  • ...
  • 生物活性
    Description: Linderane is a mechanism-based inactivator of CYP2C9.
    Targets: P450 (e.g. CYP17) | NADPH-oxidase
    In vitro:
    Xenobiotica. 2015 Jun 11:1-10.
    Mechanism-based inactivation of CYP2C9 by linderane.[Pubmed: 26068520]
    1. Linderane (LDR), a furan-containing sesquiterpenoid, is found in Lindera aggregata (Sims) Kosterm, a common traditional Chinese herbal medicine. We thoroughly studied the irreversible inhibitory effect of LDR on cytochrome P450 2C9 (CYP2C9).
    METHODS AND RESULTS:
    2. LDR caused a time- and concentration-dependent inactivation of CYP2C9. In addition, the inactivation of CYP2C9 by LDR was NADPH-dependent and irreversible. More than 50% of CYP2C9 activity was lost after its incubation with LDR at the concentration of 10 μM for 15 min at 30 °C. The maximal rate constant for inactivation (kinact) was found to be 0.0419 min(-1), and the concentration required for half-maximal inactivation (KI) was 1.26 μM, respectively. Glutathione (GSH), catalase, and superoxide dismutase (SOD) failed to protect CYP2C9 against inactivation by LDR. Diclofenac, a substrate of CYP2C9, prevented the enzyme from inactivation produced by LDR. The estimated partition ratio of the inactivation was approximately 227. 3. Two reactive intermediates, including furanoepoxide and γ-ketoenal, might be responsible for the observed enzyme inactivation. The formation of the intermediates was verified by chemical synthesis.
    CONCLUSIONS:
    Multiple P450 enzymes, including CYPs 1A2, 2B6, 2C9, 2C19, 2D6, 3A4, and 3A5, were found to be involved in the metabolic activation of LDR. In conclusion, LDR was characterized as a mechanism-based inactivator of CYP2C9.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.842 mL 19.2101 mL 38.4202 mL 76.8403 mL 96.0504 mL
    5 mM 0.7684 mL 3.842 mL 7.684 mL 15.3681 mL 19.2101 mL
    10 mM 0.3842 mL 1.921 mL 3.842 mL 7.684 mL 9.605 mL
    50 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.5368 mL 1.921 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7684 mL 0.9605 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one; 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one CFN95197 1809980-25-3 C18H24O5 = 320.4 10mg QQ客服:3257982914
    异莪术呋喃二烯; Isofuranodiene CFN98971 57566-47-9 C15H20O = 216.3 5mg QQ客服:215959384
    莪术呋喃二烯酮; Furanodienone CFN92028 24268-41-5 C15H18O2 = 230.3 20mg QQ客服:2159513211
    蓬莪术环氧酮; Zederone CFN92616 7727-79-9 C15H18O3 = 246.3 20mg QQ客服:1457312923
    钓樟内酯; Linderalactone CFN99761 728-61-0 C15H16O3 = 244.29 20mg QQ客服:2056216494
    1,2-环氧-10(14)-呋喃吉玛烯-6-酮; 1,2-Epoxy-10(14)-furanogermacren-6-one CFN95214 383368-24-9 C15H18O3 = 246.3 10mg QQ客服:2159513211
    (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one; (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one CFN95219 1393342-06-7 C16H20O3 = 260.3 5mg QQ客服:3257982914
    乌药醚内酯; Linderane CFN98175 13476-25-0 C15H16O4 = 260.28 20mg QQ客服:3257982914
    伪新乌药醚内酯; Pseudoneolinderane CFN91936 20082-45-5 C15H16O4 = 260.29 5mg QQ客服:215959384
    二氢焦蓬莪术酮; Dihydropyrocurzerenone CFN91911 59462-26-9 C15H18O = 214.30 5mg QQ客服:215959384

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