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    • 别一叶萩碱

    Viroallosecurinine

    别一叶萩碱
    		产品编号 CFN96450
    CAS编号 1857-30-3
    分子式 = 分子量 C13H15NO2 = 217.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Securinega virosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    别一叶萩碱 CFN96450 1857-30-3 1mg QQ客服：3257982914
    别一叶萩碱 CFN96450 1857-30-3 5mg QQ客服：3257982914
    别一叶萩碱 CFN96450 1857-30-3 10mg QQ客服：3257982914
    别一叶萩碱 CFN96450 1857-30-3 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Guangzhou Institutes of Biomedicine and Health (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Appl. Sci. 2021, 11(22), 10552
  • Planta Med.2019, 85(9-10):766-773
  • J Ethnopharmacol.2016, 194:219-227
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Sci Rep.2023, 13(1):21690.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • J Sep Sci.2018, 41(11):2488-2497
  • Biol Pharm Bull.2018, 41(1):65-72
  • Mol Biol Rep.2022, doi: 10.1007
  • ACS Pharmacol Transl Sci.2024, 7(2):395-405.
  • Phytomedicine.2021, 93:153789.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Processes 2021, 9(5),894.
  • Appl. Sci. 2021, 11(1),14.
  • J Ethnopharmacol.2020, 249:112396
  • Tissue Cell.2022, 78:101901.
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  • ...
    • 生物活性
    Description: Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus.
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2007 Mar;21(3):234-42.
    Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.[Pubmed: 17365714 ]
    Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), viroallosecurinine (2), 14,15-dihydrovirosecurinine (3) and ent-phyllanthidine (4). Time course studies on the growth of callus cultures were carried out. The effects of different plant growth regulators, sucrose concentrations on callus growth and virosecurinine production were also reported.
    J Ethnopharmacol. 1990 Feb;28(1):129-33.
    Antibacterial activity of the leaves of Phyllanthus discoideus.[Pubmed: 2156112]
    The lyophilized aqueous extract (LWE) from the leaves of Phyllanthus discoideus was found to show an antibacterial activity.
    METHODS AND RESULTS:
    The alkaloid fraction obtained from LWE inhibited the growth of Escherichia coli and Enterococcus faecium (MIC = 1.6 mg/ml), Pseudomonas aeruginosa (MIC = 0.78 mg/ml), Staphylococcus aureus and Mycobacterium smegmatis (MIC = 0.2 mg/ml). Among the alkaloids identified, Viroallosecurinine and securinine showed a high activity. Viroallosecurinine exhibited a MIC of 0.48 micrograms/ml for Ps. aeruginosa and Staph. aureus.
    CONCLUSIONS:
    This alkaloid is bactericidal since the yields of MIC/MBC were less than 1. The MIC of securinine was 0.500 mg/ml for E. coli, Staph. aureus and Myc. smegmatis. These effects of Phyllanthus discoideus leaf extracts support some of the local uses of the plant in traditional therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6026 mL 23.0128 mL 46.0257 mL 92.0514 mL 115.0642 mL
    5 mM 0.9205 mL 4.6026 mL 9.2051 mL 18.4103 mL 23.0128 mL
    10 mM 0.4603 mL 2.3013 mL 4.6026 mL 9.2051 mL 11.5064 mL
    50 mM 0.0921 mL 0.4603 mL 0.9205 mL 1.841 mL 2.3013 mL
    100 mM 0.046 mL 0.2301 mL 0.4603 mL 0.9205 mL 1.1506 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别一叶萩碱; Viroallosecurinine CFN96450 1857-30-3 C13H15NO2 = 217.27 5mg QQ客服：2056216494
    一叶萩碱; Securinine CFN96680 5610-40-2 C13H15NO2 = 217.26 5mg QQ客服：1413575084
    一叶萩新碱; Securitinine CFN96678 13861-71-7 C14H17NO3 = 247.29 5mg QQ客服：2056216494
    Demethyl calyciphylline A ; Demethyl calyciphylline A CFN96735 1584236-34-9 C22H29NO4 = 371.47 5mg QQ客服：215959384
    Calyciphylline A; Calyciphylline A CFN97008 596799-30-3 C23H31NO4 = 385.5 5mg QQ客服：1457312923
    虎皮楠生物碱A; Daphniyunnine A CFN97447 881388-87-0 C23H31NO3 = 369.5 5mg QQ客服：1457312923
    Longistylumphylline A; Longistylumphylline A CFN97421 857672-34-5 C23H29NO3 = 367.5 5mg QQ客服：2159513211
    Paxiphylline D; Paxiphylline D CFN99093 1092555-02-6 C23H29NO4 = 383.5 5mg QQ客服：2159513211
    Daphnilongeranin A; Daphnilongeranin A CFN97436 874201-05-5 C23H29NO4 = 383.5 5mg QQ客服：3257982914
    Paxiphylline E; Paxiphylline E CFN99094 1092555-03-7 C23H29NO5 = 399.5 5mg QQ客服：215959384

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