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  • 一叶萩碱

    Securinine

    一叶萩碱
    产品编号 CFN96680
    CAS编号 5610-40-2
    分子式 = 分子量 C13H15NO2 = 217.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves and twigs of Securinega suffruticosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    一叶萩碱 CFN96680 5610-40-2 1mg QQ客服:2159513211
    一叶萩碱 CFN96680 5610-40-2 5mg QQ客服:2159513211
    一叶萩碱 CFN96680 5610-40-2 10mg QQ客服:2159513211
    一叶萩碱 CFN96680 5610-40-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • University of Eastern Finland (Finland)
  • Mahidol University (Thailand)
  • Universita' Degli Studi Di Cagliari (Italy)
  • University of East Anglia (United Kingdom)
  • Universidad de Antioquia (Colombia)
  • University of Indonesia (Indonesia)
  • Chang Gung University (Taiwan)
  • Mendel University in Brno (Czech Republic)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Auckland (New Zealand)
  • Lund University (Sweden)
  • Chinese University of Hong Kong (China)
  • The University of Newcastle (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(2):770.
  • Int J Mol Sci.2022, 23(23):14545.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Appl. Sci. 2021, 11(17),7829
  • Molecules.2019, 24(6):E1155
  • J Plant Biotechnol.2023, 50:070-075.
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Nutrients.2021, 13(3):978.
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Nutrients.2021, 13(12):4364.
  • J Mol Histol.2019, 50(4):343-354
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Int J Mol Sci.2021, 22(16):8604.
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Antioxidants (Basel).2020, 9(6):526.
  • J of L. Chroma.&Related Tech2017, 252-258
  • Biomolecules.2020, 10(2):E184
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Appl. Sci.2020, 10(16),5482.
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Nutrients.2023, 15(13):2960.
  • Pharmacogn Mag.2015, 11:S585-91
  • ...
  • 生物活性
    Description: Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. It is alsoia promising new monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). Securinine shows antifungal activity against some plant pathogenic fungi.
    Targets: TLR | IL Receptor | GABA Receptor
    In vitro:
    Zhongguo Yao Li Xue Bao. 1999 Mar;20(3):267-70.
    Securinine induced apoptosis in human leukemia HL-60 cells.[Pubmed: 10452105]
    To study whether securinine might induce apoptosis in human leukemia HL-60 cells.
    METHODS AND RESULTS:
    Inhibition of proliferation was measured using MTT assay. The amount of apoptotic cells was measured by flow cytometry. DNA fragmentation was visualized by DNA agarose gel electrophoresis and the cellular changes were observed by electron microscope. Securinine 5-80 mg.L-1 elicited typical apoptosis morphological changes and DNA fragmentation in a concentration-dependent manner in HL-60 cells. Securinine inhibited HL-60 cell proliferation in a time- and concentration-dependent manner. The IC50 and 95% confidence limits were 27 (15-47) mg.L-1 after 12-h treatment with securinine.
    CONCLUSIONS:
    Securinine induced apoptosis in HL-60 cells.
    PLoS One. 2011;6(6):e21203.
    Securinine, a myeloid differentiation agent with therapeutic potential for AML.[Pubmed: 21731671]
    As the defining feature of Acute Myeloid Leukemia (AML) is a maturation arrest, a highly desirable therapeutic strategy is to induce leukemic cell maturation. This therapeutic strategy has the potential of avoiding the significant side effects that occur with the traditional AML therapeutics.
    METHODS AND RESULTS:
    We identified a natural compound securinine, as a leukemia differentiation-inducing agent. Securinine is a plant-derived alkaloid that has previously been used clinically as a therapeutic for primarily neurological related diseases. Securinine induces monocytic differentiation of a wide range of myeloid leukemia cell lines as well as primary leukemic patient samples. Securinine's clinical potential for AML can be seen from its ability to induce significant growth arrest in cell lines and patient samples as well as its activity in significantly impairing the growth of AML tumors in nude mice. In addition, securinine can synergize with currently employed agents such as ATRA and decitabine to induce differentiation.
    CONCLUSIONS:
    This study has revealed securinine induces differentiation through the activation of DNA damage signaling. Securinine is a promising new monocytic differentiation inducing agent for AML that has seen previous clinical use for non-related disorders.
    Mycobiology. 2008 Jun;36(2):99-101.
    Antifungal Activity of Securinine against Some Plant Pathogenic Fungi.[Pubmed: 23990741 ]

    METHODS AND RESULTS:
    The alkaloid securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (Alternaria alternata, Alternaria brassicae, Alternaria brassicicola, Curvularia lunata, Curvularia maculans, Curvularia pallenscens, Colletotrichum musae, Colletotrichum sp., Erysiphe pisi, Helminthosporium echinoclova, Helminthosporium spiciferum, Heterosporium sp.). Spore germinations of all the tested fungi were inhibited.
    CONCLUSIONS:
    Alternaria brassicicola, C. lunata, C. pallenscens and H. spiciferum were highly sensitive as complete inhibition of spore germination was observed at very low concentrations (200 ppm).
    In vivo:
    J. Leukoc. Biol.,2007, 82(5):1062-1069.
    Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists.[Reference: WebLink]
    Innate immune cell stimulation represents a complementary approach to vaccines and antimicrobial drugs to counter infectious disease.
    METHODS AND RESULTS:
    We have used assays of macrophage activation and in vitro and in vivo phase II Coxiella burnetii infection models to compare and contrast the activity of a novel innate immune cell agonist, Securinine, with known TLR agonists. As expected, TLR agonists, such as LPS (TLR4) and fibroblast-stimulating lipopeptide-1 (FSL-1; TLR2), induced macrophage activation and increased macrophage killing of phase II C. burnetii in vitro. FSL-1 also induced accelerated killing of C. burnetii in vivo. Securinine, a γ-aminobutyric acid type A receptor antagonist, was found to induce TLR-independent macrophage activation in vitro, leading to IL-8 secretion, L-selectin down-regulation, and CD11b and MHC Class II antigen up-regulation. As seen with the TLR agonists, Securinine also induced accelerated macrophage killing of C. burnetii in vitro and in vivo.
    CONCLUSIONS:
    In summary, as predicted by the literature, TLR agonists enhance macrophage killing of phase II C. burnetii in vitro, and at least for TLR2 agonists, this activity occurs in vivo as well. Securinine represents a novel macrophage agonist, which has similar effects as TLR agonists in this model yet apparently, does not act through known TLRs. Securinine has minimal toxicity in vivo, suggesting it or structurally similar compounds may represent novel, therapeutic adjuvants, which increase resistance to intracellular pathogens.ge killing of C. burnetii in vitro and in vivo. In summary, as predicted by the literature, TLR agonists enhance macrophage killing of phase II C. burnetii in vitro, and at least for TLR2 agonists, this activity occurs in vivo as well. Securinine represents a novel macrophage agonist, which has similar effects as TLR agonists in this model yet apparently, does not act through known TLRs. Securinine has minimal toxicity in vivo, suggesting it or structurally similar compounds may represent novel, therapeutic adjuvants, which increase resistance to intracellular pathogens.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6028 mL 23.0139 mL 46.0278 mL 92.0556 mL 115.0695 mL
    5 mM 0.9206 mL 4.6028 mL 9.2056 mL 18.4111 mL 23.0139 mL
    10 mM 0.4603 mL 2.3014 mL 4.6028 mL 9.2056 mL 11.507 mL
    50 mM 0.0921 mL 0.4603 mL 0.9206 mL 1.8411 mL 2.3014 mL
    100 mM 0.046 mL 0.2301 mL 0.4603 mL 0.9206 mL 1.1507 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Demethyl calyciphylline A ; Demethyl calyciphylline A CFN96735 1584236-34-9 C22H29NO4 = 371.47 5mg QQ客服:1457312923
    Calyciphylline A; Calyciphylline A CFN97008 596799-30-3 C23H31NO4 = 385.5 5mg QQ客服:1413575084
    虎皮楠生物碱A; Daphniyunnine A CFN97447 881388-87-0 C23H31NO3 = 369.5 5mg QQ客服:2056216494
    Longistylumphylline A; Longistylumphylline A CFN97421 857672-34-5 C23H29NO3 = 367.5 5mg QQ客服:2159513211
    Paxiphylline D; Paxiphylline D CFN99093 1092555-02-6 C23H29NO4 = 383.5 5mg QQ客服:215959384
    Daphnilongeranin A; Daphnilongeranin A CFN97436 874201-05-5 C23H29NO4 = 383.5 5mg QQ客服:2159513211
    Paxiphylline E; Paxiphylline E CFN99094 1092555-03-7 C23H29NO5 = 399.5 5mg QQ客服:215959384
    Daphnicyclidin D ; Daphnicyclidin D CFN96777 385384-24-7 C23H27NO4 = 381.47 5mg QQ客服:3257982914
    Daphnicyclidin F; Daphnicyclidin F CFN96778 385384-26-9 C23H27NO5 = 397.47 5mg QQ客服:215959384
    虎皮楠生物碱B; Daphniyunnine B CFN97448 881388-88-1 C21H29NO3 = 343.5 5mg QQ客服:1413575084

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