三(羟甲基)甲基甘氨酸

Tricine

	产品编号	CFN98511
	CAS编号	5704-04-1
	分子式 = 分子量	C₆H₁₃NO₅ = 179.17
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Miscellaneous
	植物来源	The roots of Beta vulgaris
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	10mg	QQ客服：1413575084
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	20mg	QQ客服：1413575084
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	50mg	QQ客服：1413575084
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Utrecht University (Netherlands)

Yale University (USA)

Universidad Miguel Hernández (Spain)

Regional Crop Research Institute (Korea)

Deutsches Krebsforschungszentrum (Germany)

Indian Institute of Science (India)

Kazusa DNA Research Institute (Japan)

The Vancouver Prostate Centre (VPC) (Canada)

University of Oslo (Norway)

Funda??o Universitária de Desenvolvimento (Brazil)

Warszawski Uniwersytet Medyczny (Poland)

Martin Luther University of Halle-Wittenberg (Germany)

Instituto de Investigaciones Agropecuarias (Chile)

University of Perugia (Italy)

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Description:

Tricine can clearly visualize tumors, may as melanoma imaging agents. Using the combination of tricine and a phosphine ligand, HYNIC-derivatized peptides or other small molecules can be labeled with 99mTc in high specific activity and with high stability for potential use as radiopharmaceuticals.

In vitro:

J. Immunol. Methods,1990 Jan 24;1 26(1):109-17.

Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis.[Pubmed: 2106001]

METHODS AND RESULTS:
We utilized the recently described tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (TSDS-PAGE) system to study the lipooligosaccharides (LOS) and lipopolysaccharides (LPS) of gram negative bacteria. TSDS-PAGE resulted in a high degree of resolution of LOS and LPS in the 'mini-gel' format. TSDS-PAGE resulted in the LOS and LPS migrating as a function of their Mr during electrophoresis and allowed estimation of Mr from a protein standard. Several species of LOS were analyzed.
CONCLUSIONS:
The newly described procedure allowed a more rapid and accurate analysis of LOS and the core region of LPS.

In vivo:

Anticancer Agents Med Chem. 2014;15(1):122-30.

Evaluation of tricine and EDDA as Co-ligands for 99mTc-labeled HYNIC-MSH analogs for melanoma imaging.[Pubmed: 25175799 ]

Several radiolabeled alpha-melanocyte stimulating hormone (α-MSH) analogs have been studied for their abilities to target melanoma tumor cells through specific recognition and binding to the melanocortin receptor 1 (MCR1).
METHODS AND RESULTS:
In this work, a lactam bridgecyclized α-MSH analog was labeled with (99m) via the hydrazinonicotinamide (HYNIC) chelator and characterized for its melanoma tumor targeting properties. The bifunctional chelating agent HYNIC-Boc was attached to the N-terminus of the MSH peptide followed by the lactam cyclization, resulting in the HYNIC-cyc-MSH analog. The lactam cyclized peptide displayed high affinity and specificity for MC1-receptors present on B16/F1 melanoma tumor cells, exhibiting an IC50 of 6.48 nM. HYNIC-cyc-MSH was radiolabeled with (99m)Tc using two common co-ligands, tricine and EDDA. In vitro, the radiochemical stability, cell binding and efflux properties were similar between the peptides radiolabeled with tricine and EDDA as co-ligands. In vivo, biodistribution studies (n=4) demonstrated that (99m)Tc- HYNIC-cyc-MSH/tricine had superior tumor to muscle and tumor to blood ratios than (99m)Tc-HYNIC-cyc-MSH/EDDA at early time points.
CONCLUSIONS:
Planar gamma imaging of melanoma bearing mice showed that 99mTc-HYNIC-cyc-MSH/tricine was able to clearly visualize tumors, underscoring the potential utility of (99m)Tc labeled lactam cyclized MSH molecules as melanoma imaging agents.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.5813 mL	27.9065 mL	55.8129 mL	111.6258 mL	139.5323 mL
5 mM	1.1163 mL	5.5813 mL	11.1626 mL	22.3252 mL	27.9065 mL
10 mM	0.5581 mL	2.7906 mL	5.5813 mL	11.1626 mL	13.9532 mL
50 mM	0.1116 mL	0.5581 mL	1.1163 mL	2.2325 mL	2.7906 mL
100 mM	0.0558 mL	0.2791 mL	0.5581 mL	1.1163 mL	1.3953 mL

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三(羟甲基)甲基甘氨酸

Tricine

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