4-氨基丁酸

4-Aminobutanoic acid

	产品编号	CFN90028
	CAS编号	56-12-2
	分子式 = 分子量	C₄H₉NO₂ = 103.12
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	From Monascus pilosus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
4-氨基丁酸	CFN90028	56-12-2	10mg	QQ客服：1413575084
4-氨基丁酸	CFN90028	56-12-2	20mg	QQ客服：1413575084
4-氨基丁酸	CFN90028	56-12-2	50mg	QQ客服：1413575084
4-氨基丁酸	CFN90028	56-12-2	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Texas A&M University (USA)

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Mendel University in Brno (Czech Republic)

Universidad Miguel Hernández (Spain)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Center for protein Engineering (CIP) (Belgium)

Centrum Menselijke Erfelijkheid (Belgium)

Heinrich-Heine-University Düsseldorf (Germany)

Gyeongsang National University (Korea)

Periyar University (India)

Lodz University of Technology (Poland)

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Description:

Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age, suggests treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vivo:

Depress Anxiety. 2014 Oct;31(10):814-21.

Anxiety in major depression and cerebrospinal fluid free 4-Aminobutanoic acid.[Pubmed: 24865448]

Low 4-Aminobutanoic acid (GABA) is implicated in both anxiety and depression pathophysiology. They are often comorbid, but most clinical studies have not examined these relationships separately.
METHODS AND RESULTS:
We investigated the relationship of cerebrospinal fluid (CSF) free 4-Aminobutanoic acid to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Psychic anxiety severity increased with age and correlated with lower CSF free 4-Aminobutanoic acid, controlling for age. CSF free 4-Aminobutanoic acid declined with age but was not related to depression severity. Other monoamine metabolites correlated positively with CSF 4-Aminobutanoic acid but not with psychic anxiety or depression severity. CSF free 4-Aminobutanoic acid was lower in MDD compared with bipolar disorder and healthy volunteers. 4-Aminobutanoic acid levels did not differ based on a suicide attempt history in mood disorders. Recent exposure to benzodiazepines, but not alcohol or past alcoholism, was associated with a statistical trend for more severe anxiety and lower CSF 4-Aminobutanoic acid.
CONCLUSIONS:
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age. This relationship is not seen with monoamine metabolites, suggesting treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	9.6974 mL	48.4872 mL	96.9744 mL	193.9488 mL	242.436 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL	38.7898 mL	48.4872 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL	19.3949 mL	24.2436 mL
50 mM	0.1939 mL	0.9697 mL	1.9395 mL	3.879 mL	4.8487 mL
100 mM	0.097 mL	0.4849 mL	0.9697 mL	1.9395 mL	2.4244 mL