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  • 单宁酸

    Tannic acid

    产品编号 CFN90501
    CAS编号 1401-55-4
    分子式 = 分子量 C76H52O46 = 1701.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The peels of Punica granatum L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    单宁酸 CFN90501 1401-55-4 10mg QQ客服:2932563308
    单宁酸 CFN90501 1401-55-4 20mg QQ客服:2932563308
    单宁酸 CFN90501 1401-55-4 50mg QQ客服:2932563308
    单宁酸 CFN90501 1401-55-4 100mg QQ客服:2932563308
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  • ...
  • 生物活性
    Description: Tannic acid has potential in the prevention of obesity.Tannic acid modifies silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.Tannic acid is directly harmful to larvae in a dose- and time-dependent manner and modulates immune responses of sheep WBC stimulated by H. contortus antigen by inhibiting Th1 cytokines and increasing Th2 cytokine expression in vitro.
    Targets: IL Receptor | ROS | Fatty Acid Synthase | PPAR | HSV | NADPH-oxidase | IFN-c | TNF-α
    In vitro:
    Parasite Immunol. 2014 Feb;36(2):100-6.
    Effects of tannic acid on Haemonchus contortus larvae viability and immune responses of sheep white blood cells in vitro.[Pubmed: 24558656]

    Direct inhibitory effects of tannic acid on Haemonchus contortus viability were studied in vitro using the larval migration inhibition (LMI) assay. Sheep white blood cells (WBC) were preincubated with 5 and 50 lg/mL tannic acid or not followed by whole H. contortus antigen (WHA). Cells were harvested at 24 h post-incubation to test host immune responses. Concentrations of 50, 100, 500, 1000, 3000 and 5000 lg/mL tannic acid inhibited larvae migration by 19.8, 42.4, 46.3, 92.0, 93.7 and 100%, respectively, within 96 h post-incubation (P < 0.001). The relative mRNA levels of interferon (IFN)-c, interleukin (IL)-2, IL-4 and IL-10 were increased by WHA stimulation without tannic acid. However, the increased effects on IFN-c and IL-2 were inhibited by tannic acid preincubation (P < 0.001), while the increases in IL-4 and IL-10 were greatly enhanced by tannic acid preincubation (P < 0.001). Changes in protein levels of all cytokines essentially paralleled the changes in their corresponding mRNA levels.
    In conclusion, tannic acid is directly harmful to larvae in a dose- and time-dependent manner and modulates immune responses of sheep WBC stimulated by H. contortus antigen by inhibiting Th1 cytokines and increasing Th2 cytokine expression in vitro.
    Biol Trace Elem Res. 2014 Apr;158(1):122-7.
    Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro Caco-2 cell model.[Pubmed: 24531910]
    Calcium, phytic acid, polyphenols and fiber are major inhibitors of iron absorption and they could be found in excess in some diets, thereby altering or modifying the iron nutrition status. The purpose of this study is to evaluate the effect of calcium, tannic acid, phytic acid, and pectin over iron uptake, using an in vitro model of epithelial cells (Caco-2 cell line).
    Caco-2 cells were incubated with iron (10-30 μM) with or without CaCl2 (500 and 1,000 μM) for 24 h. Then, cells were challenged with phytic acid (50-150 μM); pectin (50-150 nM) or tannic acid (100-500 μM) for another 24 h. Finally, (55)Fe (10 μM) uptake was determined. Iron dialyzability was studied using an in vitro digestion method. Iron uptake in cells pre-incubated with 20 and 30 μM Fe was inhibited by CaCl2 (500 μM). Iron uptake decreased in cells cultured with tannic acid (300 μM) and CaCl2 (500-1,000 μM) (two-way ANOVA, p = 0.002). Phytic acid also decreased iron uptake mainly when cells were treated with CaCl2 (1,000 μM) (two-way ANOVA; p < 0.05). Pectin slightly decreased iron uptake (p = NS). Iron dialyzability decreased when iron was mixed with CaCl2 and phytic or tannic acid (T test p < 0.0001, for both) but not when mixed with pectin.
    Phytic acid combined with calcium is a strong iron uptake inhibitor. Pectin slightly decreased iron uptake with or without calcium. Tannic acid showed an unexpected behavior, inducing an increase on iron uptake, despite its low Fe dialyzability.
    PLoS One. 2014 Aug 12;9(8):e104113.
    Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.[Pubmed: 25117537]
    The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes.
    In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection.
    Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.5878 mL 2.9391 mL 5.8782 mL 11.7564 mL 14.6955 mL
    5 mM 0.1176 mL 0.5878 mL 1.1756 mL 2.3513 mL 2.9391 mL
    10 mM 0.0588 mL 0.2939 mL 0.5878 mL 1.1756 mL 1.4696 mL
    50 mM 0.0118 mL 0.0588 mL 0.1176 mL 0.2351 mL 0.2939 mL
    100 mM 0.0059 mL 0.0294 mL 0.0588 mL 0.1176 mL 0.147 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:2159513211
    月见草素 B; Oenothein B CFN91651 104987-36-2 C68H48O44 = 1569.1 5mg QQ客服:215959384
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖; 1,2,3,6-Tetragalloylglucose CFN00447 79886-50-3 C34H28O22 = 788.57 10mg QQ客服:2159513211
    1,3,4,6-四没食子酰葡萄糖; 1,3,4,6-Tetragalloylglucose CFN95425 26922-99-6 C34H28O22 = 788.6 10mg QQ客服:3257982914
    1,3,6-三没食子酰葡萄糖; 1,3,6-Tri-O-galloylglucose CFN95043 18483-17-5 C27H24O18 = 636.5 10mg QQ客服:1148253675
    葡萄糖没食子鞣苷; beta-Glucogallin CFN70245 13405-60-2 C13H16O10 = 332.3 5mg QQ客服:3257982914
    1-O-没食子酰-6-O-肉桂酰葡萄糖; 1-O-galloyl-6-O-cinnamoylglucose CFN95053 115746-69-5 C22H22O11 = 462.4 5mg QQ客服:1413575084
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:1413575084
    1,2,3,4,6-五没食子酰葡萄糖; 1,2,3,4,6-O-Pentagalloylglucose CFN90192 14937-32-7 C41H32O26 = 940.68 20mg QQ客服:3257982914
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:2159513211





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