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  • 葡萄糖没食子鞣苷

    beta-Glucogallin

    葡萄糖没食子鞣苷
    产品编号 CFN70245
    CAS编号 13405-60-2
    分子式 = 分子量 C13H16O10 = 332.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The leaves of Camellia sinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葡萄糖没食子鞣苷 CFN70245 13405-60-2 1mg QQ客服:3257982914
    葡萄糖没食子鞣苷 CFN70245 13405-60-2 5mg QQ客服:3257982914
    葡萄糖没食子鞣苷 CFN70245 13405-60-2 10mg QQ客服:3257982914
    葡萄糖没食子鞣苷 CFN70245 13405-60-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Semmelweis Unicersity (Hungary)
  • Uniwersytet Gdański (Poland)
  • Rio de Janeiro State University (Brazil)
  • University of Brasilia (Brazil)
  • Harvard University (USA)
  • University of Amsterdam (Netherlands)
  • University of Ioannina (Greece)
  • Stanford University (USA)
  • University of Bordeaux (France)
  • University of Virginia (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Weizmann Institute of Science (Israel)
  • Max-Planck-Insitut (Germany)
  • University of Hull (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(12)
  • Food Chem.2021, 337:128023.
  • Chemistry of Natural Compounds2020, 56,423-426
  • J. Food Composition and Anal.2022, V 109:104482.
  • UDC.2020, 19(4).
  • Antioxidants (Basel).2020, 9(6):526.
  • Curr Res Virol Sci.2022, 3:100019.
  • Chung Shan Medical University2020, US20200323790A1
  • Molecules.2019, 24(19):E3417
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Lab Chip.2018, 18(6):971-978
  • Processes2021, 9(11),2065.
  • Sci Rep. 2018, 462(8)
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Biosci. Rep.2020, 10.1024
  • Molecules2022, 27(9):2827.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Anticancer Res.2020, 40(10):5529-5538.
  • LWT2020, 110397
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Mol Neurobiol.2022, 02873-9.
  • Anticancer Res.2018, 38(4):2127-2135
  • ...
  • 生物活性
    Description: Beta-glucogallin , a recently described Aldose reductase (AR) inhibitor, has antioxidant and anti-inflammatory activities.
    Targets: Aldose reductase | JNK | p38 | ROS | TNF-α | MMP | IL Recepter
    In vitro:
    Chemico Biological Interactions, 2013, 202(1-3):283-287.
    Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues.[Reference: WebLink]
    Aldose reductase (AR) catalyzes the reduction of toxic lipid aldehydes to their alcohol products and mediates inflammatory signals triggered by lipopolysaccharide (LPS). Beta-glucogallin (BGG), a recently described AR inhibitor, was purified from extracts of the Indian gooseberry (Emblica officinalis).
    METHODS AND RESULTS:
    In this study, we found that BGG showed low cytotoxicity in Raw264.7 murine macrophages and effectively inhibited AR activity as measured by a decrease in sorbitol accumulation. In addition, BGG-mediated inhibition of AR prevented LPS-induced activation of JNK and p38 and lowered ROS levels, which could inhibit LPS-induced apoptosis. Uveitis is a disease of the eye associated with chronic inflammation. In this study, we also demonstrated that treatment with BGG decreased the number of inflammatory cells that infiltrate the ocular media of mice with experimental uveitis.
    METHODS AND RESULTS:
    Accordingly, these results suggest BGG is a potential therapy for inflammatory diseases.
    Investigative Ophthalmology & Visual Science,2017,58:1177.
    Beta glucogallin, a plant-derived antioxidant and anti-inflammatory agent, alleviates corneal injury from chloropicrin exposure.[Reference: WebLink]
    There are no effective therapies to alleviate corneal injury from chloropicrin (CCl3NO2, trichloronitromethane, CP) exposure, a broad spectrum fumigant and pesticide which has been employed as a warfare agent. CP exposure-induced eye injury is associated with lacrimation and inflammation which involves corneal edema and damage. Based on completed mechanistic studies, we tested the efficacy of beta-glucogallin (BGG), a natural antioxidant and anti-inflammatory agent with anti-lipid peroxidation and carbonyl scavenger properties, hypothesized as an effective therapy against CP-induced corneal injury.
    METHODS AND RESULTS:
    Efficacy studies were carried out in primary human corneal epithelial (HCE) cells following 30 min exposure to 50 µM CP with and without treatment with either 50 µM BGG or a perfluorocarbon oxygen emulsion. Western blot analysis was assessed 24 h post exposure to determine the CP-induced effects on various molecular markers. CP injury was induced in ex vivo rabbit corneas by exposing the corneas to 200 nmol CP for 2 h, followed by washing and treatment with 10 µl of 500 µM BGG and thereafter every 6 h for 24 h. Corneal tissue was prepared for subsequent histological (H&E staining), immunohistochemical, and western blot analyses. In primary HCE cells, BGG treatment reduced CP-induced increases in cleaved PARP by 35%, H2A.X phosphorylation by 40%, MAPK-JNK phosphorylation by 43%, protein carbonylation (biotin hydrazide) by 56%, and a complete reversal in lipid peroxidation (4-hydroxynonenal, 4-HNE). Preliminary studies in HCE cells indicate that application of the oxygen emulsion reduced CP-induced phosphophorylated-p53 and cleaved PARP. In ex vivo rabbit corneas, BGG treatment resulted in a 31% reversal in CP-induced epithelial degradation and complete reversal in CP-induced COX-2 expression and protein carbonylation.
    CONCLUSIONS:
    These data suggest strong potential for BGG in reversing CP-induced lipid peroxidation and protein carbonylation as well as reducing epithelial degradation and inflammation in rabbit cornea when given 2 h after CP exposure. Further studies expanding the examination of BGG alone or in combination with oxygen emulsion in alleviating CP- and other chemical agents-induced ocular injury, and delineation of its targets and pathways is justified.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0093 mL 15.0466 mL 30.0933 mL 60.1866 mL 75.2332 mL
    5 mM 0.6019 mL 3.0093 mL 6.0187 mL 12.0373 mL 15.0466 mL
    10 mM 0.3009 mL 1.5047 mL 3.0093 mL 6.0187 mL 7.5233 mL
    50 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.2037 mL 1.5047 mL
    100 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.6019 mL 0.7523 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:215959384
    月见草素 B; Oenothein B CFN91651 104987-36-2 C68H48O44 = 1569.1 5mg QQ客服:215959384
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖; 1,2,3,6-Tetragalloylglucose CFN00447 79886-50-3 C34H28O22 = 788.57 10mg QQ客服:2056216494
    1,3,4,6-四没食子酰葡萄糖; 1,3,4,6-Tetragalloylglucose CFN95425 26922-99-6 C34H28O22 = 788.6 10mg QQ客服:2159513211
    1,3,6-三没食子酰葡萄糖; 1,3,6-Tri-O-galloylglucose CFN95043 18483-17-5 C27H24O18 = 636.5 10mg QQ客服:1457312923
    葡萄糖没食子鞣苷; beta-Glucogallin CFN70245 13405-60-2 C13H16O10 = 332.3 5mg QQ客服:1413575084
    1-O-没食子酰-6-O-肉桂酰葡萄糖; 1-O-galloyl-6-O-cinnamoylglucose CFN95053 115746-69-5 C22H22O11 = 462.4 5mg QQ客服:1413575084
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:1413575084
    1,2,3,4,6-五没食子酰葡萄糖; 1,2,3,4,6-O-Pentagalloylglucose CFN90192 14937-32-7 C41H32O26 = 940.68 20mg QQ客服:1413575084
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:2056216494

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