麻醉椒苫素

Methysticin

	产品编号	CFN90160
	CAS编号	20697-20-5
	分子式 = 分子量	C₁₅H₁₄O₅ = 274.27
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Piper methysticum
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产品名称	产品编号	CAS编号	包装	QQ客服
麻醉椒苫素	CFN90160	20697-20-5	1mg	QQ客服：1457312923
麻醉椒苫素	CFN90160	20697-20-5	5mg	QQ客服：1457312923
麻醉椒苫素	CFN90160	20697-20-5	10mg	QQ客服：1457312923
麻醉椒苫素	CFN90160	20697-20-5	20mg	QQ客服：1457312923

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Description:

Methysticin is a potent NF-kappaB inhibitor in kava with minimum toxicity, it possesses hepatotoxic, anticonvulsant and neuroprotective properties, it contributes to CYP1A1 induction.

Targets:

P450 (e.g. CYP17) | NF-kB | Calcium Channel | Potassium Channel

In vitro:

Phytother Res. 2011 Mar;25(3):417-23.

Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.[Pubmed: 20734326]

While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, Methysticin and yangonin on human hepatocytes (HepG2) and the possible mechanism(s) involved.
METHODS AND RESULTS:
Cytotoxicity was assessed using lactate dehydrogenase (LDH) and ethidium bromide (EB) assays. The mode of cell death was analysed with acridine orange/ethidium bromide dual staining with fluorescence microscopy. Glutathione oxidation was measured using the ortho-phthalaldehyde (OPT) fluorescence assay. Kavain had minimal cytotoxicity, Methysticin showed moderate concentration-dependent toxicity and yangonin displayed marked toxicity with ~ 40% reduction in viability in the EB assay. Acridine orange/ethidium bromide staining showed the predominant mode of cell death was apoptosis rather than necrosis. No significant changes were observed in glutathione levels, excluding this as the primary mechanism of cell death in this model. Further studies may elucidate the precise apoptotic pathways responsible and whether toxic kavalactone metabolites are involved.

Naunyn Schmiedebergs Arch Pharmacol. 1995 Apr;351(4):348-55.

Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices.[Pubmed: 7630425]

Methysticin is one of the constituents of Piper methysticum which possesses anticonvulsant and neuroprotective properties.
METHODS AND RESULTS:
Its effects on different in vitro seizure models were tested using extracellular recordings in rat temporal cortex slices containing the hippocampus and the entorhinal cortex. Elevating [K+]0 induced seizure-like events with tonic and clonic electrographic phases in area CA1. Lowering [Ca2+]0 caused recurrent seizure like episodes with large negative field potential shifts. Lowering Mg2+ induced short recurrent discharges in area CA3 and CA1 while ictaform events lasting for many seconds were induced in the subiculum, entorhinal and temporal neocortex. In the hippocampus the activity stayed stable over a number of hours. In contrast, the ictaform events in the subiculum, entorhinal and temporal cortex changed their characteristics after one to two hours to late recurrent discharges. In a concentration-range from 10 to 100 microM Methysticin reversibly blocked all these types of epileptiform activity. Decreases in [Ca2+]0 and associated slow field potentials evoked by repetitive stimulation of the stratum radiatum or the alveus remained almost unaffected by Methysticin. A paired pulse stimulus paradigm used to test for effects of Methysticin on synaptically evoked transient field potentials in normal medium revealed interference with mechanisms involved in frequency potentiation. While responses to alvear stimulation were largely unaffected, the responses to a paired pulse stimulus to stratum radiatum were depressed over the whole range of tested stimulus intervals.
CONCLUSIONS:
The findings suggest that Methysticin has effects on different patterns of epileptiform activity possibly by interfering with processes responsible for frequency potentiation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(6R)-(+)-5,6-二氢-6-苯乙烯基-2-吡喃酮; Goniothalamin	CFN97803	17303-67-2	C₁₃H₁₂O₂ = 200.23	5mg	QQ客服：2056216494
醉椒素; Kawain	CFN92656	500-64-1	C₁₄H₁₄O₃ = 230.3	20mg	QQ客服：2056216494
去甲氧基醉椒素; Desmethoxy yangonin	CFN90149	15345-89-8	C₁₄H₁₂O₃ = 228.24	20mg	QQ客服：2159513211
4'-羟基-5,6-脱氢醉椒素; p-Hydroxy-5,6-dehydrokawain	CFN92690	39986-86-2	C₁₄H₁₂O₄ = 244.2	10mg	QQ客服：2056216494
甲氧醉椒素; Yangonin	CFN92658	500-62-9	C₁₅H₁₄O₄ = 258.3	20mg	QQ客服：2159513211
5，6-二氢甲氧醉椒素; 5,6-Dihydroyangonin	CFN92659	3328-60-7	C₁₅H₁₆O₄ = 260.3	5mg	QQ客服：2159513211
Hispidin; Hispidin	CFN92660	56070-89-4	C₁₆H₁₆O₅ = 288.3	5mg	QQ客服：2159513211
4-Methyl-6-(3',4'-dihydroxystyryl)-2-pyrone; 4-Methyl-6-(3',4'-dihydroxystyryl)-2-pyrone	CFN91561	149947-22-8	C₁₄H₁₂O₅ = 260.2	5mg	QQ客服：1413575084
麻醉椒苫素; Methysticin	CFN90160	20697-20-5	C₁₅H₁₄O₅ = 274.27	10mg	QQ客服：215959384
二氢麻醉椒苦素; Dihydromethysticin	CFN90332	19902-91-1	C₁₅H₁₆O₅ = 276.28	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.646 mL	18.2302 mL	36.4604 mL	72.9208 mL	91.1511 mL
5 mM	0.7292 mL	3.646 mL	7.2921 mL	14.5842 mL	18.2302 mL
10 mM	0.3646 mL	1.823 mL	3.646 mL	7.2921 mL	9.1151 mL
50 mM	0.0729 mL	0.3646 mL	0.7292 mL	1.4584 mL	1.823 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	0.7292 mL	0.9115 mL

麻醉椒苫素

Methysticin

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