醉椒素

Kawain

	产品编号	CFN92656
	CAS编号	500-64-1
	分子式 = 分子量	C₁₄H₁₄O₃ = 230.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The roots of Piper methysticum Forst
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
醉椒素	CFN92656	500-64-1	10mg	QQ客服：2056216494
醉椒素	CFN92656	500-64-1	20mg	QQ客服：2056216494
醉椒素	CFN92656	500-64-1	50mg	QQ客服：2056216494
醉椒素	CFN92656	500-64-1	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Chinese University of Hong Kong (China)

Julius Kühn-Institut (Germany)

University of Cincinnati (USA)

University of Wuerzburg (Germany)

Chulalongkorn University (Thailand)

University of Fribourg (Switzerland)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

MTT Agrifood Research Finland (Finland)

University of Queensland (Australia)

Sanford Burnham Medical Research Institute (USA)

Indian Institute of Science (India)

Max Rubner-Institut (MRI) (Germany)

Regional Crop Research Institute (Korea)

More...

Description:

Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose.

Targets:

NMDAR

In vitro:

Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706.

Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.[Pubmed: 9194150]

1. The kava-pyrones Kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties.
METHODS AND RESULTS:
3. Kawain and dihydromethysticin reduced reversibly the frequency of occurrence of fp in a concentration range from 5 to 40 mumol/l and 10 to 40 mumol/l, respectively. 4. Reduction of the fp frequency after addition of subthreshold concentrations of 5 mumol/l Kawain and 10 mumol/l dihydromethysticin indicated additive actions of both drugs. 5. Since the serotonin-1A agonist ipsapirone also exerts anxiolytic effects, subthreshold concentrations of Kawain or dihydromethysticin were combined with a subthreshold concentration of ipsapirone in another set of experiments. Combining Kawain and ipsapirone or dihydromethysticin and ipsapirone caused a reduction of the rate of fp to 0.76 and 0.81 of the baseline value, respectively.
CONCLUSIONS:
6. The findings suggest that (i) single constituents of Piper methysticum may have additive actions, (ii) that the two components Kawain and dihydromethysticin may enhance the effects of the anxiolytic serotonin-1A agonist ipsapirone and (iii) that activation of NMDA receptors and/or voltage dependent calcium channels may be involved in the elementary mechanism of action of some kava-pyrones.

In vivo:

Drug Metab Dispos. 2005 Oct;33(10):1555-63.

Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.[Pubmed: 16033948]

METHODS AND RESULTS:
The oral pharmacokinetics of the kavalactone, Kawain (100 mg/kg), were determined in rats with and without coadministration of kava extract (256 mg/kg) to study the effect of the extract on drug disposition. Kawain was well absorbed, with >90% of the dose eliminated within 72 h, chiefly in urine. Compared with Kawain alone, coadministration with kava extract caused a tripling of Kawain AUC(0-8 h) and a doubling of C(max). However, a 7-day pretreatment with kava extract (256 mg /kg/day) had no effect on the pharmacokinetics of Kawain administered on day 8.
CONCLUSIONS:
The 7-day pretreatment with kava extract only modestly induced hepatic P450 activities.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(6R)-(+)-5,6-二氢-6-苯乙烯基-2-吡喃酮; Goniothalamin	CFN97803	17303-67-2	C₁₃H₁₂O₂ = 200.23	5mg	QQ客服：2056216494
醉椒素; Kawain	CFN92656	500-64-1	C₁₄H₁₄O₃ = 230.3	20mg	QQ客服：1457312923
去甲氧基醉椒素; Desmethoxy yangonin	CFN90149	15345-89-8	C₁₄H₁₂O₃ = 228.24	20mg	QQ客服：1457312923
4'-羟基-5,6-脱氢醉椒素; p-Hydroxy-5,6-dehydrokawain	CFN92690	39986-86-2	C₁₄H₁₂O₄ = 244.2	10mg	QQ客服：3257982914
甲氧醉椒素; Yangonin	CFN92658	500-62-9	C₁₅H₁₄O₄ = 258.3	20mg	QQ客服：1413575084
5，6-二氢甲氧醉椒素; 5,6-Dihydroyangonin	CFN92659	3328-60-7	C₁₅H₁₆O₄ = 260.3	5mg	QQ客服：3257982914
Hispidin; Hispidin	CFN92660	56070-89-4	C₁₆H₁₆O₅ = 288.3	5mg	QQ客服：3257982914
4-Methyl-6-(3',4'-dihydroxystyryl)-2-pyrone; 4-Methyl-6-(3',4'-dihydroxystyryl)-2-pyrone	CFN91561	149947-22-8	C₁₄H₁₂O₅ = 260.2	5mg	QQ客服：3257982914
麻醉椒苫素; Methysticin	CFN90160	20697-20-5	C₁₅H₁₄O₅ = 274.27	10mg	QQ客服：2159513211
二氢麻醉椒苦素; Dihydromethysticin	CFN90332	19902-91-1	C₁₅H₁₆O₅ = 276.28	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3422 mL	21.7108 mL	43.4216 mL	86.8432 mL	108.5541 mL
5 mM	0.8684 mL	4.3422 mL	8.6843 mL	17.3686 mL	21.7108 mL
10 mM	0.4342 mL	2.1711 mL	4.3422 mL	8.6843 mL	10.8554 mL
50 mM	0.0868 mL	0.4342 mL	0.8684 mL	1.7369 mL	2.1711 mL
100 mM	0.0434 mL	0.2171 mL	0.4342 mL	0.8684 mL	1.0855 mL

醉椒素

Kawain

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