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  • 赤芝酸D2

    Lucidenic acid D2

    赤芝酸D2
    产品编号 CFN95020
    CAS编号 98665-16-8
    分子式 = 分子量 C29H38O8 = 514.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤芝酸D2 CFN95020 98665-16-8 1mg QQ客服:1413575084
    赤芝酸D2 CFN95020 98665-16-8 5mg QQ客服:1413575084
    赤芝酸D2 CFN95020 98665-16-8 10mg QQ客服:1413575084
    赤芝酸D2 CFN95020 98665-16-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Harvard University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Life Science2018, 917-922
  • Molecules 2022, 27(3),1047.
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Front Pharmacol.2016, 7:460
  • Sci Rep. 2017, 12953(7)
  • Analytical Methods2018, 10(27)
  • Antioxidants (Basel).2020, 9(6):466.
  • Sci Rep.2023, 13(1):7475.
  • Int J Biol Macromol.2019, 126:653-661
  • Plants (Basel).2021, 10(7):1376.
  • Molecules.2018, 23(7):E1659
  • Antioxidants.2022, 11(3):592.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Int J Mol Sci.2015, 16(1):1232-51
  • Molecules.2019, 24(4):E709
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Molecules.2017, 22(12)
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • FEBS Lett.2015, 589(1):182-7
  • Food and Fermentation Industries2019, 45(7):45-51
  • Biomed Pharmacother.2023, 163:114785.
  • J Med Food.2021, 24(3):209-217.
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • ...
  • 生物活性
    Description: Lucidenic acid D2 is a nartural product from G. lucidum AF.
    Targets: TNF-α | p38MAPK
    In vitro:
    Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24.
    Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.[Pubmed: 21453678 ]
    The Ganoderma lucidum (G. lucidum) is one of the oriental fungi that has been reported to have immunomodulatory properties. Although effect of β-glucans from G. lucidum has been well documented, little is known about how other major bioactive components, the triterpenes, contribute to the immunomodulatory function of G. lucidum.
    METHODS AND RESULTS:
    Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα production, while JNK inhibitor enhanced TNFα production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid A, Lucidenic acid F and Lucidenic acid D2, which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively.
    CONCLUSIONS:
    Thus, our data demonstrate that lucidenic acids-rich extract from G. lucidum AF enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.
    In vivo:
    Planta Medica, 2015, 81(11).
    Biological activities of triterpenes isolated from the medicinal mushroom Ganoderma lucidum.[Reference: WebLink]

    METHODS AND RESULTS:
    Methanol extract of Ganoderma lucidum subjected to fractionation on silica gel medium pressure column afforded over 40 fractions. Further fractionation was carried out using Centrifugal Partition Chromatography (FCPC Rousselet Robatel, France), in the hexane-EtOAc-MeOH-Water systems adjusted for the polarity of each fraction. Some isolates were further purified by preparative HPLC. Methyl esters of ganoderic and lucidenic acids were obtained by methylation of the acids. Twelve compounds, including ganoderic acid A (1), methyl ganoderate A (2), methyl lucidenate A (3), methyl lucidenate F (4), Lucidenic acid D2 (5), lucidenic acid A (6), lucidenic acid N (7), ganoderic acid DM (8), ganoderic acid F (9), ganoderic acid C (10), ganoderiol F (11) and ganodermonondiol (12) were evaluated for their biological activities. Antibacterial activity was determined against Gram -positive and -negative bacteria, anti-inflammatory effect against endotoxin (lipolysaccharide, LPS) induced inflammatory response in human macrophages, and anti-proliferative effects in human breast and colon cancer cells.
    CONCLUSIONS:
    We identified ganoderic acid DM as the most potent triterpene with anti-bacterial, anti-inflammatory and anti-proliferative effects when compared to other Ganoderma isolates.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9433 mL 9.7163 mL 19.4326 mL 38.8651 mL 48.5814 mL
    5 mM 0.3887 mL 1.9433 mL 3.8865 mL 7.773 mL 9.7163 mL
    10 mM 0.1943 mL 0.9716 mL 1.9433 mL 3.8865 mL 4.8581 mL
    50 mM 0.0389 mL 0.1943 mL 0.3887 mL 0.7773 mL 0.9716 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3887 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝酸C甲酯; Methyl lucidenate C CFN95541 N/A C28H42O7 = 490.6 5mg QQ客服:2056216494
    赤芝酸SP1; Lucidenic acid SP1 (Lucidenic acid LM1) CFN92994 364622-33-3 C27H40O6 = 460.60 5mg QQ客服:1413575084
    20(21)-脱氢赤芝酸A; 20(21)-Dehydrolucidenic acid A CFN90829 852936-69-7 C27H36O6 = 456.6 10mg QQ客服:2056216494
    赤芝酮B; Lucidone B CFN91025 97653-93-5 C24H32O5 = 400.51 5mg QQ客服:3257982914
    灵芝酸G; Ganoderic acid G CFN90801 98665-22-6 C30H44O8 = 532.7 20mg QQ客服:2056216494
    20-羟基灵芝酸G; 20-Hydroxyganoderic acid G CFN91014 400604-12-8 C30H44O9 = 548.67 5mg QQ客服:215959384
    灵芝酸N; Ganoderic acid N CFN90293 110241-19-5 C30H42O8 = 530.65 10mg QQ客服:2159513211
    灵芝烯酸A; Ganoderenic acid A CFN92236 100665-40-5 C30H42O7 = 514.7 10mg QQ客服:1413575084
    灵芝烯酸D; Ganoderenic acid D CFN90300 100665-43-8 C30H40O7 = 512.64 20mg QQ客服:2056216494
    灵芝烯酸D甲酯; Methyl ganoderenate D CFN95572 748136-03-0 C31H42O7 = 526.7 5mg QQ客服:3257982914

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