| Description: |
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibition of Na+ and the Ito channel. Liriodenine also has antimuscarinic properties, the antimuscarinic characteristics are similar to those of 4-diphenylacetoxy-N-methylpiperidine (4-DAMP, smooth muscle selective M3 antagonist), it may act as a selective M3 receptor antagonist in canine tracheal smooth muscle.
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| In vitro: |
| Oncol Lett. 2015 Mar;9(3):1121-1127. | | Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression.[Pubmed: 25663867] | Liriodenine, an alkaloid extracted from a number of plant species, has demonstrated antitumor effects on multiple types of cancer. However, the effects of Liriodenine upon laryngocarcinoma, and the underlying mechanisms, are yet to be elucidated.
METHODS AND RESULTS:
The present study therefore investigated the potential antitumor effects of Liriodenine on HEp-2 human laryngocarcinoma cells in vitro and HEp-2-implanted nude mice in vivo. Liriodenine induced significant apoptosis and inhibition of cell migration in the HEp-2 cells. Furthermore, the rate of tumor growth in the HEp-2-implanted nude mice was inhibited by the administration of Liriodenine. The potential mechanism underlying the antitumor effects of Liriodenine may result from an upregulative effect upon p53 expression, which ultimately induces cellular apoptosis. By contrast, the downregulation of p53 significantly reduced the antitumor effects of Liriodenine.
CONCLUSIONS:
Together, these results suggest that Liriodenine exhibits potent antitumor activities in laryngocarcinoma HEp-2 cells, in vitro and in vivo, via the upregulation of p53 expression. Liriodenine may therefore be a potential therapy for the treatment of laryngocarcinoma. | | Z Naturforsch C. 2011 Jul-Aug;66(7-8):377-84. | | Liriodenine, early antimicrobial defence in Annona diversifolia.[Pubmed: 21950162] | Annonaceae aporphine alkaloids, of which Liriodenine is the most abundant, have not been extensively studied from a biological standpoint. The goal of this study was to investigate the role of Liriodenine in antimicrobial defense during early developmental stages in Annona diversifolia.
METHODS AND RESULTS:
The fungi Rhizopus stolonifer and Aspergillus glaucus, which are responsible for seed deterioration, were isolated during imbibition, and their antifungal activity was determined by diffusion, macrodilution, and metabolic inhibition assays using purified Liriodenine and alkaloid extracts obtained from embryos, radicles, and roots at early developmental stages. The presence of Liriodenine in extracts was quantified by high-performance liquid chromatography. Purified Liriodenine and alkaloidal extracts inhibited both fungi, and there was a positive relationship between extract activity and amount of Liriodenine contained therein.
CONCLUSIONS:
The quantity of Liriodenine present in extracts suggests its importance in controlling other phytopathogens. |
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