新木姜子素

Neolitsine

	产品编号	CFN97947
	CAS编号	2466-42-4
	分子式 = 分子量	C₁₉H₁₇NO₄ = 323.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The leaves of Laurus nobilis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
新木姜子素	CFN97947	2466-42-4	1mg	QQ客服：1457312923
新木姜子素	CFN97947	2466-42-4	5mg	QQ客服：1457312923
新木姜子素	CFN97947	2466-42-4	10mg	QQ客服：1457312923
新木姜子素	CFN97947	2466-42-4	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Instytut Nawozów Sztucznych w Pu?awach (Poland)

University Medical Center Mainz (Germany)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

University of Leipzig (Germany)

Chinese University of Hong Kong (China)

Celltrion Chemical Research Institute (Korea)

University of British Columbia (Canada)

University of Maryland School of Medicine (USA)

Mendel University in Brno (Czech Republic)

Sant Gadge Baba Amravati University (India)

Gyeongsang National University (Korea)

Mahidol University (Thailand)

National Research Council of Canada (Canada)

Funda??o Universitária de Desenvolvimento (Brazil)

More...

Description:

Neolitsine has anthelmintic activity, it exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL.Neolitsine and dicentrine have potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM.

In vitro:

Planta Med. 2007 Mar;73(3):296-7.

Anthelmintic activity of aporphine alkaloids from Cissampelos capensis.[Pubmed: 17309014 ]

METHODS AND RESULTS:
Two known aporphine alkaloids, (S)-dicentrine (1) and (S)-Neolitsine (2), have been isolated from the MeOH extract of the aerial parts of Cissampelos capensis (Menispermaceae). The structures of these compounds were elucidated by NMR and MS analysis and comparison to literature data. These compounds were isolated by bioassay-guided fractionation using the Haemonchus contortus larval development assay.
CONCLUSIONS:
Compounds 1 and 2 exhibited EC90 values (concentration at which 90% loss of larval motility is observed) of 6.3 and 6.4 microg/mL, respectively. In an IN VIVO assay, administration of 1 resulted in 67% reduction of worm counts in mice at 25 mg/kg when dosed orally.

J Nat Prod. 2008 Feb;71(2):289-91.

Vasorelaxing alkaloids and flavonoids from Cassytha filiformis.[Pubmed: 18217715 ]

METHODS AND RESULTS:
Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid ( 3), cassythine ( 4), neolitsine ( 7), and dicentrine ( 8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyaporphine ( 2), (-)- O-methylflavinatine ( 10), (-)-salutaridine ( 11), isohamnetin-3- O-beta-glucoside, and isohamnetin-3- O-rutinoside exerted moderate vessel-relaxing activities with IC 50 values from 16.50 to 32.81 microM at the test concentrations.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Dehydroformouregine; Dehydroformouregine	CFN96155	107633-69-2	C₂₀H₁₉NO₄ = 337.4	5mg	QQ客服：2159513211
6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine; 6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine	CFN89485	2101836-45-5	C₂₁H₂₁NO₅ = 367.39	5mg	QQ客服：215959384
无根藤灵; Cassyfiline	CFN97889	4030-51-7	C₁₉H₁₉NO₅ = 341.4	5mg	QQ客服：1457312923
10-O-甲基汝兰碱; 1,2-Methylenedioxy-3,10,11-trimethoxynoraporphine	CFN96039	14050-90-9	C₂₀H₂₁NO₅ = 355.4	5mg	QQ客服：3257982914
阿朴雷因; Aporheine	CFN97932	2030-53-7	C₁₈H₁₇NO₂ = 279.3	5mg	QQ客服：3257982914
新木姜子素; Neolitsine	CFN97947	2466-42-4	C₁₉H₁₇NO₄ = 323.4	5mg	QQ客服：1413575084
氧代海罂粟碱; Oxoglaucine	CFN90508	5574-24-3	C₂₀H₁₇NO₅ = 351.34	5mg	QQ客服：3257982914
鹅掌楸碱; Liriodenine	CFN98715	475-75-2	C₁₇H₉NO₃ = 275.3	5mg	QQ客服：1413575084
Lauterine; Lauterine	CFN96757	28200-65-9	C₁₈H₁₁NO₄ = 305.28	5mg	QQ客服：215959384
观音莲明碱; Lysicamine	CFN93254	15444-20-9	C₁₈H₁₃NO₃ = 291.3	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0921 mL	15.4607 mL	30.9215 mL	61.8429 mL	77.3036 mL
5 mM	0.6184 mL	3.0921 mL	6.1843 mL	12.3686 mL	15.4607 mL
10 mM	0.3092 mL	1.5461 mL	3.0921 mL	6.1843 mL	7.7304 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	1.2369 mL	1.5461 mL
100 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.6184 mL	0.773 mL