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  • 丹芝酸E

    Ganolucidic acid E

    丹芝酸E
    产品编号 CFN95536
    CAS编号 114567-50-9
    分子式 = 分子量 C30H44O5 = 484.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹芝酸E CFN95536 114567-50-9 1mg QQ客服:2056216494
    丹芝酸E CFN95536 114567-50-9 5mg QQ客服:2056216494
    丹芝酸E CFN95536 114567-50-9 10mg QQ客服:2056216494
    丹芝酸E CFN95536 114567-50-9 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • China Medical University (Taiwan)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Univerzita Karlova v Praze (Czech Republic)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Regional Crop Research Institute (Korea)
  • Medical University of Gdansk (Poland)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Michigan State University (USA)
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  • University of Canterbury (New Zealand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Molecules.2019, 24(10):E1930
  • Front Pharmacol.2021, 12:652860.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Biorxiv.2020, doi: 10.1101.
  • Front Pharmacol.2021, 12:764297.
  • Virulence.2018, 9(1):588-603
  • Int J Mol Med.2019, 43(6):2516-2522
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • J Med Food.2021, 24(3):209-217.
  • J of Essential Oil Research2019, 1677272
  • BMC Cancer. 2021, 21(1):91.
  • Nutr Cancer.2023, 75(1):376-387.
  • Processes2022, 10(10), 2008.
  • Molecules2022, 27(9):2827.
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Food Chem.2019, 279:80-87
  • JMicrobiol Biotech Food Sci2021, e4289.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • ...
  • 生物活性
    Description: Ganolucidic acid E inhibits the growth of three types of human cancer cells: Caco-2, HepG2 and HeLa cells.
    In vitro:
    Phytother Res . 2015 Nov;29(11):1744-1752.
    Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells[Pubmed: 26292672]
    The medicinal mushroom Ganoderma lucidum is well recognized for its effective cancer-preventative and therapeutic properties, while specific components responsible for these anticancer effects are not well studied. Six triterpenoids that are ganolucidic acid E, lucidumol A, ganodermanontriol, 7-oxo-ganoderic acid Z, 15-hydroxy-ganoderic acid S, and ganoderic acid DM were isolated and identified from an extract of the mushroom. All compounds reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 μM. Moreover, the six compounds induced apoptosis in HeLa cells with a maximum increase (22%) of sub-G1 accumulations and 43.03% apoptotic cells in terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay (15-hydroxy-ganoderic acid S treatment). Apoptosis was further confirmed by annexin-V staining. Four of the compounds also caused apoptosis in Caco-2 cells with maximum 9.5% increase of sub-G1 accumulations (7-oxo-ganoderic acid Z treatment) and maximum 29.84% apoptotic cells in TUNEL assay (ganoderic acid DM treatment). Contrarily, none of the compounds induced apoptosis in HepG2 cells. The different responses of the three cell lines following these treatments indicated that the bioactive properties of these compounds may vary from cells of different sites of origin and are likely acting under diverse regulatory mechanisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3157 mL 20.6313 mL 41.2626 mL 51.5783 mL
    5 mM 0.4126 mL 2.0631 mL 4.1263 mL 8.2525 mL 10.3157 mL
    10 mM 0.2063 mL 1.0316 mL 2.0631 mL 4.1263 mL 5.1578 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8253 mL 1.0316 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:1457312923
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:2056216494
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:3257982914
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:1457312923
    11-酮基灵芝酸DM; 11-Keto-ganoderic acid DM CFN95593 N/A C30H42O5 = 482.7 5mg QQ客服:3257982914
    灵芝醇 D; Ganoderiol D CFN95568 114567-45-2 C30H48O5 = 488.7 5mg QQ客服:3257982914
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:2056216494
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:2056216494
    新化合物19; New compound 19 CFN95538 N/A C32H42O8 = 554.7 5mg QQ客服:215959384
    灵芝酸GS-3; Ganoderic acid GS-3 CFN95518 1206781-66-9 C32H46O8 = 558.7 5mg QQ客服:1413575084

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