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  • 灵芝酸Y

    Ganoderic acid Y

    产品编号 CFN90294
    CAS编号 86377-52-8
    分子式 = 分子量 C30H46O3 = 454.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸Y CFN90294 86377-52-8 1mg QQ客服:1413575084
    灵芝酸Y CFN90294 86377-52-8 5mg QQ客服:1413575084
    灵芝酸Y CFN90294 86377-52-8 10mg QQ客服:1413575084
    灵芝酸Y CFN90294 86377-52-8 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Bonn (Germany)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Beira Interior (Portugal)
  • University of Virginia (USA)
  • Ateneo de Manila University (Philippines)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Utah State University (USA)
  • University of Wisconsin-Madison (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Padjajaran (Indonesia)
  • National Research Council of Canada (Canada)
  • China Medical University (Taiwan)
  • University of Lodz (Poland)
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  • ...
  • 生物活性
    Description: Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating.
    Targets: Antifection
    In vitro:
    Biochem Biophys Res Commun. 2014 Jul 4;449(3):307-12.
    Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection.[Pubmed: 24845570]
    Enterovirus 71 (EV71) is a major causative agent for hand, foot and mouth disease (HFMD), and fatal neurological and systemic complications in children. However, there is currently no clinical approved antiviral drug available for the prevention and treatment of the viral infection.
    Here, we evaluated the antiviral activities of two Ganoderma lucidum triterpenoids (GLTs), Lanosta-7,9(11),24-trien-3-one,15;26-dihydroxy (GLTA) and Ganoderic acid Y (GLTB), against EV71 infection. The results showed that the two natural compounds display significant anti-EV71 activities without cytotoxicity in human rhabdomyosarcoma (RD) cells as evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell proliferation assay. The mechanisms by which the two compounds affect EV71 infection were further elucidated by three action modes using Ribavirin, a common antiviral drug, as a positive control.
    The results suggested that GLTA and GLTB prevent EV71 infection through interacting with the viral particle to block the adsorption of virus to the cells. In addition, the interactions between EV71 virion and the compounds were predicated by computer molecular docking, which illustrated that GLTA and GLTB may bind to the viral capsid protein at a hydrophobic pocket (F site), and thus may block uncoating of EV71. Moreover, we demonstrated that GLTA and GLTB significantly inhibit the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating. Thus, GLTA and GLTB may represent two potential therapeutic agents to control and treat EV71 infection.
    Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
    Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
    We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and Ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro.
    Phytochemistry . 2018 May;149:103-115.
    Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase[Pubmed: 29490285]
    Abstract Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z3, 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes. Keywords: Ganoderma resinaceum; Ganodermataceae; Lanostane triterpenes; α-Glucosidase inhibitor.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9967 mL 21.9935 mL 43.987 mL 54.9837 mL
    5 mM 0.4399 mL 2.1993 mL 4.3987 mL 8.7974 mL 10.9967 mL
    10 mM 0.2199 mL 1.0997 mL 2.1993 mL 4.3987 mL 5.4984 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0997 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:215959384
    灵芝酸T-Q; Ganoderic acid T-Q CFN92237 112430-66-7 C32H46O5 = 510.7 5 mg QQ客服:2159513211
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:2056216494
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:215959384
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:2056216494
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:2159513211
    11-酮基灵芝酸DM; 11-Keto-ganoderic acid DM CFN95593 N/A C30H42O5 = 482.7 5mg QQ客服:2056216494
    灵芝醇 D; Ganoderiol D CFN95568 114567-45-2 C30H48O5 = 488.7 5mg QQ客服:1457312923
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:1457312923





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