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  • 蔷薇酸; 野鸦椿酸

    Euscaphic acid

    蔷薇酸; 野鸦椿酸
    产品编号 CFN98888
    CAS编号 53155-25-2
    分子式 = 分子量 C30H48O5 = 488.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The dried fruit of Ziziphus jujuba.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蔷薇酸; 野鸦椿酸 CFN98888 53155-25-2 1mg QQ客服:2159513211
    蔷薇酸; 野鸦椿酸 CFN98888 53155-25-2 5mg QQ客服:2159513211
    蔷薇酸; 野鸦椿酸 CFN98888 53155-25-2 10mg QQ客服:2159513211
    蔷薇酸; 野鸦椿酸 CFN98888 53155-25-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Uniwersytet Gdański (Poland)
  • Sapienza University of Rome (Italy)
  • Complutense University of Madrid (Spain)
  • University of Bordeaux (France)
  • The University of Newcastle (Australia)
  • Wroclaw Medical University (Poland)
  • Ain Shams University (Egypt)
  • Aarhus University (Denmark)
  • Seoul National University (Korea)
  • Subang Jaya Medical Centre (Malaysia)
  • Universiti Sains Malaysia (Malaysia)
  • University of Padjajaran (Indonesia)
  • Mahatma Gandhi University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomed Pharmacother.2022, 146:112497.
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • American Association for Anatomy2020, doi: 10.1002.
  • Antioxidants (Basel).2021, 10(10):1638.
  • Am J Chin Med.2016, 44(8):1719-1735
  • Mol Pharm.2017, 14(9):3164-3177
  • Toxicol In Vitro.2022, 81:105346.
  • Molecules 2022, 27(3),960.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Chung Shan Medical University2020, US20200323790A1
  • Appl. Sci.2020, 10,1304
  • Food Res Int.2020, 128:108778
  • Molecules.2019, 24(1):E159
  • Molecules.2021, 26(8):2161.
  • Nutrients.2018, 10(7)
  • Phytomedicine.2021, 84:153501.
  • PLoS One.2021, 16(9):e0257243.
  • J Nat Med.2017, 71(2):457-462
  • Nutrients.2019, 11(6):E1380
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Molecules.2019, 25(1):E103
  • BMC Complement Altern Med.2019, 19(1):367
  • Antioxidants (Basel).2020, 9(4):326.
  • ...
  • 生物活性
    Description: Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations. Euscaphic acid induces death by activation of caspase-3, dependent apoptotic pathway. Euscaphic acid and tormentic acid have inhibitory effect on high fat diet-induced obesity in the rat. Euscaphic acid also has anti-contraction effects on rat’s aortic smooth muscle.
    Targets: LDL | NO | PGE | TNF-α | NOS | COX | NF-kB | JNK | ERK | p38MAPK | Calcium Channel | Sodium Channel | ATPase | Potassium Channel | IkB | IKK
    In vitro:
    Adv Life Sci. Technol., 2015, 33.
    Anti-Contraction Effects of Euscaphic Acid Isolated from Crataegus azarolus var. aronia L on Rat’s Aortic Smooth Muscle.[Reference: WebLink]
    The current study represents the first attempt to investigate the effect of the Euscaphic acid (EA) on Rats isolated thoracic aortic smooth muscle cells.
    METHODS AND RESULTS:
    Isolated aorta was used to test the anti-contraction effects and the possible mode of action(s) of the EA (1*10 -7 M) and (3*10 -7 M) isolated from Crataegus azarolus var. aronia L. Euscaphic acid showed high anti-contraction effects on norepinephrin (NE), (1*10 -9 -10 -4 M) induced contraction in aortic smooth muscle cells in endothelium-intact, endothelium-denuded, and aortic rings pre-incubated with potassium (K + )-channels blocker (tetraethylammonium, TEA), prostaglandin I 2 (PGI ) inhibitor (indomethacin) and cyclic guanosine monophosphate (cGMP) inhibitor ( methylene blue). On the other hand, other K 2 channels subtype blockers glibenclamide (GLIB); barium chloride (BaCl ) and 4-aminopyridine (4-AP) demonstrated that adenosine triphosphate sensitive K + (K ATP ), inwardly rectifying K 2 + (K ir ) and voltage-dependent K ) channels played no role in anti-contraction induced by EA. Furthermore, the role of L-types calcium (Ca ) channels in EA anti-contractile effects on aortic smooth muscle cells was proved, by using the Ca -channel blocker verapamil, as indicated by the production of a potent anti-contraction effect . The results of the current study indicate that the anti-contraction effects of EA may be due to the activation of calcium dependent, K ) channels and blocking of L-type Ca ++ channels.
    CONCLUSIONS:
    Thus, from these results it can be concluded that both K and Ca ++ channels play an important role in anti-contraction effects of EA, which are mediated possibly through opening of K channels and blockade of voltage-dependent calcium channels, which may justify the use of medicinal plant C. azarolus in cardiovascular disease.
    Am J Transl Res . 2019 Apr 15;11(4):2090-2098. eCollection 2019.
    Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway[Pubmed: 31105820]
    Abstract Rubus alceaefolius Poir. has been used for the treatment of nasopharyngeal carcinoma (NPC) in China for many years. Euscaphic acid is an active component of Rubus alceaefolius Poir. However, the mechanism of action of euscaphic acid in NPC remains unclear. In this study, Euscaphic acid inhibited the proliferation of NPC cells, induced apoptosis, and led to cell cycle arrest in the G1/S phase. In addition, euscaphic acid inhibited the expression of phosphatidylinositide 3-kinases (PI3K), phosphorylated protein kinase B (p-AKT), and phosphorylated mammalian target of rapamycin (p-mTOR) p-mTOR in NPC cells. The activation of the PI3K/AKT/mTOR signaling pathway by IGF-1 promoted cell proliferation, inhibited apoptosis, and cell cycle arrest in NPC cells. In conclusion, we demonstrated that euscaphic acid reduced cell proliferation and induced apoptosis and cell cycle arrest in NPC cells by suppressing the PI3K/AKT/mTOR signaling pathway. Keywords: AKT; Euscaphic acid; PI3K; mTOR; nasopharyngeal carcinoma.
    In vivo:
    Korean J. Pharmacogn., 2005, 36(4):324-31.
    Inhibitory effect of euscaphic acid and tormentic acid from the roots of Rosa rugosa on high fat diet-induced obesity in the rat.[Reference: WebLink]
    The roots of Rosa rugosa have been used to treat diabetes mellitus in the folkloric society of Korea.
    METHODS AND RESULTS:
    To demonstrate the active component for the rat obesity induced by high fat diet for 6 weeks, the phytochemical fractionation and the pharmacological activity test were performed on this crude drug. It was shown that the methanolic extract and its EtOAc fraction inhibited the weight increase of the rat body, abdominal fat pad and hyperlipidemia at 200 mg/kg dose. Further, the triterpenoids, Euscaphic acid and tormentic acid, isolated from R. rugosa roots were active at 30 mg/kg in the same assay. The two components shifted serum total-, HDL, and LDL-cholesterol levels toward the values of the unteated group, suggesting that the active compounds has hypolipidemic effects. The rats fed Euscaphic acid and tormentic acid also reduced thiobarbituric acid-reactive substance (TBARS) and hydroxyl radical in the rat blood and increased Superoxide dismutase activity compared to the control. TBARS values and carbonyl content of the hepatic protein were reduced by treatment with the two triterpenoids. Antioxidative enzyme (SOD, glutathione peroxidase, and catalase) activities in hepatic tissues were increased by treatment of rats with the triterpenoids, which suggests that triterpenoids inhibited the reduction of hepatic antioxidative activity caused by high fat diet.
    CONCLUSIONS:
    Taken together, these results support that Euscaphic acid and tormentic acid improve a high fat diet-induced hyperlipidemia via the activation of antioxidative mechanism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,3-Di-O-methylthiomethyleuscaphic acid; 2,3-Di-O-methylthiomethyleuscaphic acid CFN97578 N/A C34H56O5S2 = 609.0 5mg QQ客服:215959384
    2,3-O-异亚丙基刺梨酸; 2,3-O-Isopropylidenyl euscaphic acid CFN98095 220880-90-0 C33H52O5 = 528.8 5mg QQ客服:3257982914
    2-表委陵菜酸; 2-Epitormentic acid CFN99310 119725-19-8 C30H48O5 = 488.7 5mg QQ客服:1148253675
    2-氧代果树酸; 2-氧代坡模醇酸; 2-Oxopomolic acid CFN98920 54963-52-9 C30H46O5 = 486.7 5mg QQ客服:1413575084
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid; 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 C30H46O5 = 486.69 5mg QQ客服:3257982914
    覆盆子酸; Fupenzic acid CFN99311 119725-20-1 C30H44O5 = 484.7 5mg QQ客服:2932563308
    Negundonorin A; Negundonorin A CFN96848 1401618-51-6 C29H40O5 = 468.63 5mg QQ客服:3257982914
    1-beta-羟基蔷薇酸; 1beta-Hydroxyeuscaphic acid CFN92609 120211-98-5 C30H48O6 = 504.7 5mg QQ客服:1148253675
    1,2,3,19-四羟基-12-乌苏烯-28-酸; 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid CFN99233 113558-03-5 C30H48O6 = 504.7 5mg QQ客服:1413575084
    1-羟基-2-氧代果树酸; 1-Hydroxy-2-oxopomolic acid CFN98080 217466-37-0 C30H46O6 = 502.7 5mg QQ客服:1413575084

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