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  • (+)-表松脂酚

    (+)-Epipinoresinol

    (+)-表松脂酚
    产品编号 CFN92288
    CAS编号 24404-50-0
    分子式 = 分子量 C20H22O6 = 358.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The heartwoods of Picea excelsa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (+)-表松脂酚 CFN92288 24404-50-0 1mg QQ客服:2159513211
    (+)-表松脂酚 CFN92288 24404-50-0 5mg QQ客服:2159513211
    (+)-表松脂酚 CFN92288 24404-50-0 10mg QQ客服:2159513211
    (+)-表松脂酚 CFN92288 24404-50-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Worcester Polytechnic Institute (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Hawaii Cancer Center (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Subang Jaya Medical Centre (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2021, 11(1):14180.
  • Front Microbiol.2022, 12:833233.
  • Front Aging Neurosci.2019, 11:230
  • Antioxidants.2022, 11(3):491.
  • Toxicol In Vitro.2019, 59:161-178
  • Molecules.2018, 23(7):E1659
  • Sci Rep.2019, 9(1):4342
  • Biomed Pharmacother.2020, 128:110318.
  • Cytotechnology.2017, 69(5):765-773
  • Toxicological Research2020, doi: 10.1007.
  • Mol Microbiol.2019, 112(1):317-332
  • Phytochem Anal.2013, 24(5):493-503
  • J Biomol Struct Dyn.2022, 1-21.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • PLoS One.2015, 10(5):e0127060
  • Int Immunopharmacol.2020, 90:107268.
  • Br J Pharmacol.2020, 10.1111
  • Biology (Basel).2020, 9(11):363.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Biomedicines.2022, 10(5):1170
  • Foods.2021, 10(12):2929.
  • EXCLI J.2023, 22:482-498.
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Zhongguo Zhong yao za zhi,2013, 38(14):2321-2324.
    Chemical constituents from stems of Brucea mollis and their cytotoxic activity.[Reference: WebLink]

    METHODS AND RESULTS:
    Ten compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as deacetylated isobrucein B (1), indaquassin X (2), cleomiscosin A (3), cleomiscosin B (4), (+)-lyoniresinol (5), (+)-epipinoresinol(6), (+)-pinoresinol (7), (+)-syringaresinol (8), 4,5-dihydroblumenol A (9) and adenosine (10) on the basis of spectroscopic data analysiS. All compounds were obtained from this plant for the first time, moreover, compound 1 was a new natural product.
    CONCLUSIONS:
    Compound 2 showed significant cytotoxic activities against the human cell lines HT-29, HepG2, BGC-823 and SKOV3 with IC50 values of 0.84-3.97 micromol x L(-1).
    Plant Cell Physiol . 2018 Nov 1;59(11):2278-2287.
    Formation of a Methylenedioxy Bridge in (+)-Epipinoresinol by CYP81Q3 Corroborates with Diastereomeric Specialization in Sesame Lignans[Pubmed: 30085233]
    Abstract Plant specialized metabolites are often found as lineage-specific diastereomeric isomers. For example, Sesamum alatum accumulates the specialized metabolite (+)-2-episesalatin, a furofuran-type lignan with a characteristic diastereomeric configuration rarely found in other Sesamum spp. However, little is known regarding how diastereomeric specificity in lignan biosynthesis is implemented in planta. Here, we show that S. alatum CYP81Q3, a P450 orthologous to S. indicum CYP81Q1, specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-epipinoresinol to produce (+)-pluviatilol. Both (+)-epipinoresinol and (+)-pluviatilol are putative intermediates of (+)-2-episesalatin based on their diastereomeric configurations. On the other hand, CYP81Q3 accepts neither (+)- nor (-)-pinoresinol as a substrate. This diastereomeric selectivity of CYP81Q3 is in clear contrast to that of CYP81Q1, which specifically converts (+)-pinoresinol to (+)-sesamin via (+)-piperitol by the sequential formation of two MDBs but does not accept (+)-epipinoresinol as a substrate. Moreover, (+)-pinoresinol does not interfere with the conversion of (+)-epipinoresinol to (+)-pluviatilol by CYP81Q3. Amino acid substitution and CO difference spectral analyses show that polymorphic residues between CYP81Q1 and CYP81Q3 proximal to their putative substrate pockets are crucial for the functional diversity and stability of these two enzymes. Our data provide clues to understanding how the lineage-specific functional differentiation of respective biosynthetic enzymes substantiates the stereoisomeric diversity of lignan structures.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:1457312923
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:3257982914
    (-)-丁香树脂酚-4-O-beta-D-呋喃芹糖基-(1→2)-beta-D-吡喃葡萄糖苷; (-)-Syringaresinol 4-(2''-apiosylglucoside) CFN99504 136997-64-3 C33H44O17 = 712.69 20mg QQ客服:1413575084
    (+)-表松脂酚; (+)-Epipinoresinol CFN92288 24404-50-0 C20H22O6 = 358.4 5mg QQ客服:2056216494
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:215959384
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:215959384
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:3257982914
    连翘脂素; Phillygenin CFN90511 487-39-8 C21H24O6 = 372.41 20mg QQ客服:2159513211
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:2159513211
    (+)-杜仲树脂酚双葡萄糖苷; (+)-Mediresinol Di-O-beta-D-glucopyranoside CFN91840 88142-63-6 C33H44O17 = 712.7 5mg QQ客服:1457312923

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