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  • 连翘苷

    Phillyrin

    连翘苷
    产品编号 CFN99998
    CAS编号 487-41-2
    分子式 = 分子量 C27H34O11 = 534.56
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Forsythia suspensa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    连翘苷 CFN99998 487-41-2 10mg QQ客服:2056216494
    连翘苷 CFN99998 487-41-2 20mg QQ客服:2056216494
    连翘苷 CFN99998 487-41-2 50mg QQ客服:2056216494
    连翘苷 CFN99998 487-41-2 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of South Carolina (USA)
  • Kitasato University (Japan)
  • University of Oslo (Norway)
  • CSIRO - Agriculture Flagship (Australia)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Utah State University (USA)
  • Complutense University of Madrid (Spain)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Medicine and Pharmacy (Romania)
  • University of South Australia (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Helsinki (Finland)
  • Periyar University (India)
  • University of Brasilia (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2017, 24:77-86
  • Food Chem Toxicol.2023, 176:113785.
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Nat Commun.2023, 14(1):4540.
  • Current Pharmaceutical Analysis2017, 13(5)
  • J Pharm Anal.2016, 6(6):363-373
  • Food and Chemical Toxicology2020, 111221
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • Cancers (Basel).2023, 15(1):37.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Nutrients.2021, 13(1):254.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Front Pharmacol.2017, 8:205
  • Molecules.2020, 25(15):3353.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Molecules.2021, 26(9):2526.
  • Plant Direct.2021, 5(12):e372.
  • Journal of Functional Foods2019, 52:430-441
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Molecules.2020, 25(18):4283.
  • Advances in Traditional Medicine2020, 10.1007
  • Food Bioscience2022, 50:102187.
  • ...
  • 生物活性
    Description: Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
    Targets: Fatty Acid Synthase | AMPK | ROS | Bcl-2/Bax | TNF-α | IL Receptor | MAPK | NF-kB
    In vitro:
    Food Chem. 2013 Jan 15;136(2):415-25.
    Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling.[Pubmed: 23122079]
    Phillyrin, an active constituent found in many medicinal plants and certain functional foods, has anti-obesity activity in vivo. The aim of our study was to provide new data on the molecular mechanism(s) underlying the role of phillyrin in the prevention of high glucose-induced lipid accumulation in human HepG2 hepatocytes.
    METHODS AND RESULTS:
    We found that phillyrin suppressed high glucose-induced lipid accumulation in HepG2 cells. Phillyrin strongly inhibited high glucose-induced fatty acid synthase (FAS) expression by modulating sterol regulatory element-binding protein-1c (SREBP-1c) activation. Moreover, use of the pharmacological AMP-activated protein kinase (AMPK) inhibitor compound C revealed that AMPK is essential for suppressing SREBP-1c expression in phillyrin-treated cells. Finally, we found that liver kinase B1 (LKB1) phosphorylation is required for the phillyrin-enhanced activation of AMPK in HepG2 hepatocytes.
    CONCLUSIONS:
    These results indicate that phillyrin prevents lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation, suggesting that phillyrin is a novel AMPK activator with a role in the prevention and treatment of obesity.
    Xenobiotica . 2017 Apr;47(4):297-303.
    Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro[Pubmed: 27310729]
    Abstract 1. Phillyrin and forsythoside A are two important active ingredients in Forsythia suspensa. However, the effects of phillyrin and forsythoside A on the activities of cytochrome P450 (CYP450) remain unclear. 2. This study aimed to investigate the effects of phillyrin and forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro. 3. Many pharmacokinetic parameters of caffeine and metoprolol in phillyrin pretreatment group, caffeine and tolbutamide in forsythoside A pretreatment group were affected significantly. In rat liver microsomal incubation system, the concentrations of acetaminophen and dextrophan in the phillyrin pretreatment group are higher than blank control group by 207.69% and 125.00%, however, the concentrations of 4-hydroxytolbutamide and 6β-hydroxytestosterone were not significantly altered. The concentrations of acetaminophen and 4-hydroxytolbutamide in the forsythoside A pretreatment group are higher than blank control group by 223.07% and 154.16%, whereas the concentrations of dextrophan and 6β-hydroxytestosterone were not significantly altered. 4. These results indicated that Phillyrin had potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities. Moreover, forsythoside A had inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities. Keywords: CYP1A2; CYP2C11; CYP2D1; CYP3A1/2; cytochrome P450; forsythoside A; phillyrin.
    In vivo:
    Zhong Yao Cai. 2005 Feb;28(2):123-4.
    [Effect of phillyrin on the anti-obesity in nutritive obesity mice].[Pubmed: 15981888]
    To study on the anti-obesity effect of phillyrin in nutritive obesity mice.
    METHODS AND RESULTS:
    The alimentary obesity model was established by hyperalimentation. The wet weight of fat, fat index, number of fat cells per unit visual field, Lee's index, jejunum microvillus area, serum triglyceride and cholesterol were selected to observe the anti-obesity effect of phillyrin. Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol.
    CONCLUSIONS:
    Phillyrin has anti-obesity effect in nutritive obesity mice.
    Arch Pharm Res . 2016 Jul;39(7):998-1005.
    Protective effects of phillyrin against influenza A virus in vivo[Pubmed: 27323762]
    Abstract Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus. Keywords: Influenza A virus; Mouse; Phillyrin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8707 mL 9.3535 mL 18.707 mL 37.4139 mL 46.7674 mL
    5 mM 0.3741 mL 1.8707 mL 3.7414 mL 7.4828 mL 9.3535 mL
    10 mM 0.1871 mL 0.9353 mL 1.8707 mL 3.7414 mL 4.6767 mL
    50 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.7483 mL 0.9353 mL
    100 mM 0.0187 mL 0.0935 mL 0.1871 mL 0.3741 mL 0.4677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:2159513211
    (-)-松脂醇; (-)-Pinoresinol CFN92287 81446-29-9 C20H22O6 = 358.4 5mg QQ客服:215959384
    (-)-丁香树脂酚; (-)-Syringaresinol CFN92500 6216-81-5 C22H26O8 = 418.4 10mg QQ客服:2056216494
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:2056216494
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:2159513211
    (-)-丁香树脂酚-4-O-beta-D-呋喃芹糖基-(1→2)-beta-D-吡喃葡萄糖苷; (-)-Syringaresinol 4-(2''-apiosylglucoside) CFN99504 136997-64-3 C33H44O17 = 712.69 20mg QQ客服:2159513211
    (+)-表松脂酚; (+)-Epipinoresinol CFN92288 24404-50-0 C20H22O6 = 358.4 5mg QQ客服:2056216494
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:215959384
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:2159513211
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:1413575084

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