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  • 延胡索甲素

    Corydaline

    延胡索甲素
    产品编号 CFN90196
    CAS编号 518-69-4
    分子式 = 分子量 C22H27NO4 = 369.44
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The tubers of Corydalis ambigua
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    延胡索甲素 CFN90196 518-69-4 10mg QQ客服:2159513211
    延胡索甲素 CFN90196 518-69-4 20mg QQ客服:2159513211
    延胡索甲素 CFN90196 518-69-4 50mg QQ客服:2159513211
    延胡索甲素 CFN90196 518-69-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Mysore (India)
  • University of Toulouse (France)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Aveiro University (Portugal)
  • University of Vienna (Austria)
  • S.N.D.T. Women's University (India)
  • Wageningen University (Netherlands)
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  • Anna University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Chromatographica2016, 29(3)
  • Food Chem.2019, 278:683-691
  • Phytother Res.2022, ptr.7573.
  • BMC Complement Altern Med.2019, 19(1):367
  • Nutrients.2021, 13(8):2901.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Front Aging Neurosci.2018, 10:269
  • Ecol Evol.2022, 12(11):e9459.
  • Biomed Pharmacother.2022, 145:112474.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Foods2023, 12(23), 4342.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Phytomedicine.2018, 47:48-57
  • Processes2021, 9(1), 153.
  • Front Microbiol.2022, 12:833233.
  • Molecules2022, 27(14):4601
  • Research Square2023, 2883170.
  • Phytomedicine.2019, 55:229-237
  • ...
  • 生物活性
    Description: Corydaline is an acetylcholinesterase inhibitor, is also an inhibitor of CYP2C19 and CYP2C9. Corydaline has antiallergic, and antinociceptive activities. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation.
    Targets: P450 (e.g. CYP17) | NADPH-oxidase
    In vitro:
    J Sep Sci. 2012 May;35(9):1102-9.
    In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry.[Pubmed: 22689485]
    Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It exhibits the antiacetylcholinesterase, antiallergic, antinociceptive, and gastric emptying activities. The purposes of this study were to establish in vitro metabolic pathways of corydaline in human liver microsomes and hepatocytes by identification of their metabolites using liquid chromatography-ion trap mass spectrometry.
    METHODS AND RESULTS:
    Human liver microsomal incubation of corydaline in the presence of an NADPH-generating system resulted in the formation of nine metabolites, namely, four O-desmethylcorydaline [M1 (yuanhunine), M2 (9-O-desmethylcorydaline), M3 (isocorybulbine), and M4 (corybulbine)], three di-O-desmethylcorydaline [M5 (9,10-di-O-desmethylcorydaline), M6 (2,10-di-O-desmethylcorydaline), and M7 (3,10-di-O-desmethylcorydaline)], M8 (hydroxyyuanhunine), and M9 (hydroxycorydaline). Incubation of corydaline in human hepatocytes produced four metabolites including M1, M5, M6, and M9.
    CONCLUSIONS:
    O-Demethylation and hydroxylation were the major metabolic pathways for the metabolism of corydaline in human liver microsomes and hepatocytes.
    J Asian Nat Prod Res . 2017 Nov;19(11):1124-1133.
    Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression[Pubmed: 29034730]
    Abstract Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future. Keywords: COX-2; Corydaline; MAPK; enterovirus 71.
    In vivo:
    Xenobiotica. 2014 Nov 28:1-8.
    Gender differences in corydaline pharmacokinetics in rats.[Pubmed: 25430796]
    1. Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent, DA-9701. It has been recommended that preclinical pharmacokinetic studies of natural medicines include both genders. Therefore, in this study, the pharmacokinetics of Corydaline in male and female rats was evaluated following intravenous and oral administration of pure Corydaline or DA-9701.
    METHODS AND RESULTS:
    2. After intravenous administration of Corydaline, the area under the plasma concentration-time curve (AUC) was significantly greater (by 46.4%) in female rats compared to male rats due to a 29.3% reduction in non-renal clearance in female rats. The gender difference in Corydaline hepatic metabolic clearance was supported by a significantly slower metabolism of Corydaline in hepatic microsomes of female rats mediated via male-specific (CYP2C11 and CYP3A2) or male-dominant (CYP3A1) CYP isozymes. 3. Following oral administration of pure Corydaline or DA-9701, the AUC and Cmax values of Corydaline in female rats were significantly greater (by 793% and 466% increase for Corydaline administration or by 501% and 143% increase for DA-9701 administration) than in male rats. Greater F values of Corydaline in female rats could be due to smaller hepatic first-pass extraction as a result of slower hepatic metabolism of Corydaline. 4. However, we observed a comparable disappearance of Corydaline in male and female human liver microsomes, consistent with little gender difference in CYP2C9 and CYP3A activities in humans compared to that in rats.
    CONCLUSIONS:
    Thus, gender differences in Corydaline metabolism are not expected to occur in humans.
    Biol Pharm Bull. 2010;33(6):958-62.
    Effects of corydaline from Corydalis tuber on gastric motor function in an animal model.[Pubmed: 20522959]
    The aim of this study was to evaluate the prokinetic and gastric-relaxing effects of the isoquinoline alkaloid corydaline, which was extracted from Corydalis tubers (CT). Corydaline is a marker compound used for quality control of DA-9701, a prokinetic agent formulated from extracts of Pharbitidis semen and Corydalis tuber that is currently in clinical trials in Korea for the treatment of functional dyspepsia (FD). DA-9701 was previously reported to be a potential therapeutic agent for the treatment of abnormalities in gastrointestinal motor function in FD patients; however, the therapeutic effects of corydaline on FD have yet to be demonstrated in an in vivo study.
    METHODS AND RESULTS:
    In the current study, oral administration of corydaline not only significantly accelerated gastric emptying in normal rats but also improved delayed gastric emptying to near normal levels. Furthermore, corydaline induced significant gastric relaxation, shifting the pressure-volume curve towards higher volumes compared to controls.
    CONCLUSIONS:
    These results suggest that corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation.
    Sci Rep . 2020 Aug 14;10(1):13804.
    Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists[Pubmed: 32796875]
    Abstract Pain remains a key therapeutic area with intensive efforts directed toward finding effective and safer analgesics in light of the ongoing opioid crisis. Amongst the neurotransmitter systems involved in pain perception and modulation, the mu-opioid receptor (MOR), a G protein-coupled receptor, represents one of the most important targets for achieving effective pain relief. Most clinically used opioid analgesics are agonists to the MOR, but they can also cause severe side effects. Medicinal plants represent important sources of new drug candidates, with morphine and its semisynthetic analogues as well-known examples as analgesic drugs. In this study, combining in silico (pharmacophore-based virtual screening and docking) and pharmacological (in vitro binding and functional assays, and behavioral tests) approaches, we report on the discovery of two naturally occurring plant alkaloids, corydine and corydaline, as new MOR agonists that produce antinociceptive effects in mice after subcutaneous administration via a MOR-dependent mechanism. Furthermore, corydine and corydaline were identified as G protein-biased agonists to the MOR without inducing β-arrestin2 recruitment upon receptor activation. Thus, these new scaffolds represent valuable starting points for future chemical optimization towards the development of novel opioid analgesics, which may exhibit improved therapeutic profiles.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7068 mL 13.534 mL 27.068 mL 54.136 mL 67.67 mL
    5 mM 0.5414 mL 2.7068 mL 5.4136 mL 10.8272 mL 13.534 mL
    10 mM 0.2707 mL 1.3534 mL 2.7068 mL 5.4136 mL 6.767 mL
    50 mM 0.0541 mL 0.2707 mL 0.5414 mL 1.0827 mL 1.3534 mL
    100 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.5414 mL 0.6767 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    元胡宁; Yuanhunine CFN95179 104387-15-7 C21H25NO4 = 355.4 5mg QQ客服:2056216494
    延胡索甲素; Corydaline CFN90196 518-69-4 C22H27NO4 = 369.44 20mg QQ客服:3257982914
    脱氢紫堇碱; Dehydrocorydalin CFN90330 30045-16-0 C22H24NO4 = 366.44 20mg QQ客服:215959384
    脱氢卡维丁; Dehydrocavidine CFN90407 83218-34-2 C21H18NO4 = 348.4 5mg QQ客服:2056216494
    去氢延胡索甲素硝酸盐; Dehydrocorydaline nitrate CFN90604 13005-09-9 C22H24NO4.NO3 = 428.44 5mg QQ客服:1413575084
    甲基黄连碱; Worenine CFN90415 38763-29-0 C20H16NO4+ = 334.11 5mg QQ客服:1413575084
    新化合物23; New compound 23 CFN95587 N/A C20H16NO4+ = 334.4 5mg QQ客服:1413575084
    紫堇沙明碱; Corysamine chloride CFN91710 11028-77-6 C20H16ClNO4 = 369.8 5mg QQ客服:1413575084

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