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  • 头花千金藤二酮B

    • 头花千金藤二酮B

    Cepharadione B

    头花千金藤二酮B
    		产品编号 CFN94151
    CAS编号 55610-02-1
    分子式 = 分子量 C19H15NO4 = 321.33
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Stephania cepharantha Hayata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    头花千金藤二酮B CFN94151 55610-02-1 1mg QQ客服：3257982914
    头花千金藤二酮B CFN94151 55610-02-1 5mg QQ客服：3257982914
    头花千金藤二酮B CFN94151 55610-02-1 10mg QQ客服：3257982914
    头花千金藤二酮B CFN94151 55610-02-1 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2020, 10(23), 8729
  • Molecules.2019, 24(9):E1719
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Bio-protocol2018, 9(14):e3301
  • Plant Cell Tiss Org2020, 1-16
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • J Med Food.2021, 24(2):151-160.
  • Neuropharmacology.2018, 131:68-82
  • Appl. Sci.2020, 10(20), 7323.
  • J Breast Cancer.2015, 18(2):112-118
  • Biomolecules.2019, 9(11):E696
  • J Med Food.2022, 25(3):272-280.
  • Environ Toxicol.2022, 37(3):514-526.
  • J Biomed Sci.2020, 27(1):60.
  • Chem Biol Interact.2022, 368:110248.
  • Oncol Rep.2016, 35(3):1356-64
  • Food Chem Toxicol.2023, 176:113802.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Pharmacol Rep.2019, 71(2):289-298
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Inflammation.2022, 45(6):2529-2543.
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • ...
    • 生物活性
    Description: Cepharadione B exhibits strong tyrosinase inhibitory activity with an IC50 value of 170 microM. It also exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
    Targets: Tyrosinase
    In vitro:
    Chem. Pharm. Bull. (Tokyo)., 2009 ,57(11):1227-30.
    The constituents and their bioactivities of Houttuynia cordata.[Pubmed: 19881272]

    METHODS AND RESULTS:
    Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated.
    CONCLUSIONS:
    Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
    Arch. Pharm.Res., 2001, 24(6):518-21.
    Cytotoxic alkaloids from Houttuynia cordata.[Pubmed: 11794526]

    METHODS AND RESULTS:
    Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata.
    CONCLUSIONS:
    Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1121 mL 15.5603 mL 31.1207 mL 62.2413 mL 77.8016 mL
    5 mM 0.6224 mL 3.1121 mL 6.2241 mL 12.4483 mL 15.5603 mL
    10 mM 0.3112 mL 1.556 mL 3.1121 mL 6.2241 mL 7.7802 mL
    50 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.2448 mL 1.556 mL
    100 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.6224 mL 0.778 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    头花千金藤二酮B; Cepharadione B CFN94151 55610-02-1 C19H15NO4 = 321.33 5mg QQ客服：2159513211
    头花千金藤二酮A; Cepharadione A CFN96041 55610-01-0 C18H11NO4 = 305.3 5mg QQ客服：1413575084
    番荔枝碱; (-)-Anonaine CFN91018 1862-41-5 C17H15NO2 = 265.31 5mg QQ客服：1413575084
    莲碱; Roemerine CFN91019 548-08-3 C18H17NO2 = 279.33 5mg QQ客服：1457312923
    瓜馥木碱甲; Fissistigine A CFN91767 70420-58-5 C18H17NO4 = 311.33 5mg QQ客服：1457312923
    Laetanine; Laetanine CFN93031 72361-67-2 C18H19NO4 = 313.35 10mg QQ客服：3257982914
    去甲异波尔定; Laurolitsine CFN90492 5890-18-6 C18H19NO4 = 313.34 5mg QQ客服：2159513211
    去甲异波尔定; Norisoboldine CFN99528 23599-69-1 C18H19NO4 = 313.35 20mg QQ客服：215959384
    去甲海罂粟碱盐酸盐; Norglaucine hydrochloride CFN96271 39945-41-0 C20H24ClNO4 = 377.9 5mg QQ客服：2159513211
    Dehydroformouregine; Dehydroformouregine CFN96155 107633-69-2 C20H19NO4 = 337.4 5mg QQ客服：2159513211

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