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  • 乙酰紫堇灵

    Acetylcorynoline

    乙酰紫堇灵
    产品编号 CFN99749
    CAS编号 18797-80-3
    分子式 = 分子量 C23H23NO6 = 409.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The tubers of Corydalis ambigua
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰紫堇灵 CFN99749 18797-80-3 10mg QQ客服:215959384
    乙酰紫堇灵 CFN99749 18797-80-3 20mg QQ客服:215959384
    乙酰紫堇灵 CFN99749 18797-80-3 50mg QQ客服:215959384
    乙酰紫堇灵 CFN99749 18797-80-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • Kyoto University (Japan)
  • Michigan State University (USA)
  • University of Minnesota (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Northeast Normal University Changchun (China)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Amsterdam (Netherlands)
  • Sri Ramachandra University (India)
  • Chiang Mai University (Thailand)
  • University of Leipzig (Germany)
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  • Weizmann Institute of Science (Israel)
  • University of Vienna (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Cell Mol Med.2023, jcmm.18071.
  • Korean J Dent Mater2020, 47(2):63-70.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Food and Fermentation Industries2018, 44(371)
  • Int J Mol Sci.2020, 21(22):8816.
  • Molecules.2021, 26(2):313.
  • Food Chemistry: X.2022, 2022.100270
  • Oncotarget.2017, 8(64):108006-108019
  • Food Chem Toxicol.2023, 176:113785.
  • Int J Mol Sci.2022, 23(20):12516.
  • Molecules.2020, 25(9):2111.
  • Phytother Res.2019, 33(4):1104-1113
  • Applied Biological Chem. 2020, 26(63).
  • mBio.2020, 11(3):e00686-20.
  • Toxins (Basel).2022, 14(12):824.
  • Chem Res Toxicol.2023, 36(2):213-229.
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Sci Rep. 2017, 8207(7)
  • Antiviral Res.2013, 98(3):386-93
  • Chemistry of Natural Compounds2020, 56,423-426
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • Molecules.2020, 25(15):3353.
  • ...
  • 生物活性
    Description: Acetylcorynoline has anti-inflammatory properties, it also has potential to improve parkinson's disease, it may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. It has protective action against experimental liver injury in mice.
    Targets: TNF-α | IL Receptor | IkB | IKK
    In vivo:
    Neuropharmacology. 2014 Jul;82:108-20.
    Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.[Pubmed: 23973292]
    Parkinson's disease (PD), the second most common neurodegenerative disease, impairs motor skills and cognitive function. To date, the drugs used for PD treatment provide only symptomatic relief. The identification of new drugs that show benefit in slowing the decline seen in PD patients is the focus of much current research. Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, a traditional Chinese medical herb. It has been shown to have anti-inflammatory properties, but no studies have yet described the effects of Acetylcorynoline on PD. The aim of this study was to evaluate the potential for Acetylcorynoline to improve PD in Caenorhabditis elegans models.
    METHODS AND RESULTS:
    In the present study, we used a pharmacological strain (BZ555) that expresses green fluorescent protein specifically in dopaminergic neurons, and a transgenic strain (OW13) that expresses human α-synuclein in muscle cells to study the antiparkinsonian effects of Acetylcorynoline. Our experimental data showed that treatment with up to 10 mM Acetylcorynoline does not cause toxicity in animals. Acetylcorynoline significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; prevents α-synuclein aggregation; recovers lipid content in OW13 strain; restores food-sensing behavior, and dopamine levels; and prolongs life-span in 6-hydroxydopamine-treated N2 strain, thus showing its potential as a possible antiparkinsonian drug.
    CONCLUSIONS:
    Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes.
    Yao Xue Xue Bao. 1997 May;32(5):331-6.
    [Protective action of corynoline, acetylcorynoline and protopine against experimental liver injury in mice].[Pubmed: 11498866]

    METHODS AND RESULTS:
    Oral administration of two doses of corynoline, acetylcorynoline or protopine at 50 and 100 mg.kg-1 in an interval of 8 to 24 h before i.p. injection of CCl4, acetaminophen or thioacetamide significantly impeded the elevation of serum transaminase (SGPT) and liver damage in mice. The three compounds were found to inhibit CCl4-induced microsomal lipid peroxidation and CCl4 conversing to carbon monoxide in liver microsomes in vitro.
    CONCLUSIONS:
    Of these compounds, acetylcorynoline was shown to be more potent than corynoline and protopine. In addition, all the three compounds exhibited biphasic effects on the hepatic cytochrome P450, i.e. inhibition followed by induction, in mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4424 mL 12.2121 mL 24.4242 mL 48.8484 mL 61.0605 mL
    5 mM 0.4885 mL 2.4424 mL 4.8848 mL 9.7697 mL 12.2121 mL
    10 mM 0.2442 mL 1.2212 mL 2.4424 mL 4.8848 mL 6.106 mL
    50 mM 0.0488 mL 0.2442 mL 0.4885 mL 0.977 mL 1.2212 mL
    100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.4885 mL 0.6106 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    博落回醇碱; Bocconoline CFN95373 32906-88-0 C22H21NO5 = 379.4 5mg QQ客服:1457312923
    6-乙酰甲基-N-甲基-二氢德卡林碱; 6-Acetonyl-N-methyl-dihydrodecarine CFN99367 1253740-09-8 C23H21NO5 = 391.4 5mg QQ客服:2056216494
    6-乙酰甲基白屈菜红碱; 6-Acetonyldihydrochelerythrine CFN98233 22864-92-2 C24H23NO5 = 405.5 5mg QQ客服:1413575084
    8-乙酰甲基二氢血根碱; 8-Acetonyldihydrosanguinarine CFN98608 37687-34-6 C23H19NO5 = 389.4 5mg QQ客服:3257982914
    8-乙酰甲基二氢勒樘碱; 8-Acetonyldihydroavicine CFN92338 348098-59-9 C23H19NO5 = 389.4 5mg QQ客服:2159513211
    8-乙酰甲基二氢两面针碱; 8-Acetonyldihydronitidine CFN92339 80330-39-8 C24H23NO5 = 405.5 5mg QQ客服:2159513211
    bis[6-(5,6-dihydrochelerythrinyl)]amine; bis[6-(5,6-dihydrochelerythrinyl)]amine CFN91015 165393-48-6 C42H37N3O8 = 711.76 5mg QQ客服:215959384
    乙酰紫堇灵; Acetylcorynoline CFN99749 18797-80-3 C23H23NO6 = 409.43 20mg QQ客服:2159513211
    白屈菜碱; Chelidonine CFN90319 476-32-4 C20H19NO5 = 353.37 20mg QQ客服:1457312923
    二氢白屈菜红碱; Dihydrochelerythrine CFN90127 6880-91-7 C21H19NO4 = 349.38 20mg QQ客服:1413575084

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