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  • 8-羟基-5,7-二甲氧基黄烷酮

    8-Hydroxy-5,7-dimethoxyflavanone

    8-羟基-5,7-二甲氧基黄烷酮
    产品编号 CFN95580
    CAS编号 201230-40-2
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Chloranthus spicatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-羟基-5,7-二甲氧基黄烷酮 CFN95580 201230-40-2 1mg QQ客服:1413575084
    8-羟基-5,7-二甲氧基黄烷酮 CFN95580 201230-40-2 5mg QQ客服:1413575084
    8-羟基-5,7-二甲氧基黄烷酮 CFN95580 201230-40-2 10mg QQ客服:1413575084
    8-羟基-5,7-二甲氧基黄烷酮 CFN95580 201230-40-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(16):8604.
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  • ...
  • 生物活性
    Description: 8-Hydroxy-5,7-dimethoxyflavanone represents a useful tumor-preventive phytochemical that triggers p53-driven G2/M cell cycle arrest and apoptosis.PDMF(8-Hydroxy-5,7-dimethoxyflavanone) as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions.8-hydroxy-5,7-dimethoxyflavanone has anti-inflammatory activity.
    In vitro:
    Cytotechnology . 2018 Jun;70(3):899-912.
    A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma[Pubmed: 28710570]
    Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, PDMF; 8-hydroxy-5,7-dimethoxyflavanone) shows carcinostatic activity on human lung adenocarcinoma, A549. We found that treatment with PDMF significantly inhibited cell proliferation and decreased viability through induction of G2/M cell cycle arrest and apoptosis. The PDMF stimulation induces phosphorylation of tumor suppressor p53 on Ser15, and increases its protein amount in conjunction with up-regulation of downstream cyclin-dependent kinase inhibitor p21Cip1/Waf1 and proapoptotic caspases, caspase-9 and caspase-3. We also found that small interfering RNA knockdown of p53 completely abolished the PDMF-induced G2/M cell cycle arrest, and substantially abrogated its proapoptotic potency. These results suggest that PDMF represents a useful tumor-preventive phytochemical that triggers p53-driven G2/M cell cycle arrest and apoptosis.
    Biochem Biophys Res Commun . 2017 Jan 29;483(1):674-679.
    A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions[Pubmed: 27986566]
    Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P. frutescens-derived anti-inflammatory polyphenols. We also show that oral administration of PDMF not only suppresses passive cutaneous anaphylaxis, but also prevents allergic rhinitis-like nasal symptoms in a murine model of Japanese cedar pollinosis. Mechanistically, PDMF negatively regulates Akt phosphorylation and intracellular Ca2+ influx, both of which are essential for mast cell secretory granule translocation and its exocytosis upon high-affinity IgE receptor (FcεRI) cross-linking. These results represent PDMF as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions.
    In vivo:
    Biochem Biophys Res Commun . 2017 Jan 29;483(1):674-679.
    A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions[Pubmed: 27986566]
    Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P. frutescens-derived anti-inflammatory polyphenols. We also show that oral administration of PDMF not only suppresses passive cutaneous anaphylaxis, but also prevents allergic rhinitis-like nasal symptoms in a murine model of Japanese cedar pollinosis. Mechanistically, PDMF negatively regulates Akt phosphorylation and intracellular Ca2+ influx, both of which are essential for mast cell secretory granule translocation and its exocytosis upon high-affinity IgE receptor (FcεRI) cross-linking. These results represent PDMF as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基黄烷酮; 7-Hydroxyflavanone CFN94487 6515-36-2 C15H12O3 = 240.26 20mg QQ客服:3257982914
    松属素; 乔松素; Pinocembrin CFN98740 480-39-7 C15H12O4 = 256.3 20mg QQ客服:1457312923
    7-乙酸-5,7-二羟基二氢黄酮酯; Pinocembrin 7-acetate CFN99096 109592-60-1 C17H14O5 = 298.3 5mg QQ客服:1413575084
    二乙酸松属素酯; Pinocembrin diacetate CFN99211 111441-88-4 C19H16O6 = 340.3 5mg QQ客服:3257982914
    球松素; 乔松酮; Pinostrobin CFN98739 480-37-5 C16H14O4 = 270.3 20mg QQ客服:3257982914
    山姜素; Alpinetin CFN98489 36052-37-6 C16H14O4 = 270.3 20mg QQ客服:2056216494
    5,7-二甲氧基黄烷酮; 5,7-Dimethoxyflavanone CFN92662 1036-72-2 C17H16O4 = 284.3 5mg QQ客服:2159513211
    (2R)-5,7-Dimethoxyflavanone; (2R)-5,7-Dimethoxyflavanone CFN90899 1277188-85-8 C17H16O4 = 284.31 5mg QQ客服:2159513211
    二氢黄芩素; Dihydrobaicalein CFN93796 35683-17-1 C15H12O5 = 272.3 5mg QQ客服:1413575084
    二氢木蝴蝶素A; Dihydrooroxylin A CFN92591 18956-18-8 C16H14O5 = 286.3 5mg QQ客服:2159513211

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