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  • 5-羟基-4-甲氧基铁屎米酮

    5-Hydroxy-4-methoxycanthin-6-one

    5-羟基-4-甲氧基铁屎米酮
    产品编号 CFN99846
    CAS编号 18110-86-6
    分子式 = 分子量 C15H10N2O3 = 266.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Picrasma quassioides (D.Don) Benn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-羟基-4-甲氧基铁屎米酮 CFN99846 18110-86-6 1mg QQ客服:1457312923
    5-羟基-4-甲氧基铁屎米酮 CFN99846 18110-86-6 5mg QQ客服:1457312923
    5-羟基-4-甲氧基铁屎米酮 CFN99846 18110-86-6 10mg QQ客服:1457312923
    5-羟基-4-甲氧基铁屎米酮 CFN99846 18110-86-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Pol J Microbiol.2021, 70(1):117-130.
  • Applied Biological Chem. 2020, 26(63).
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  • ...
  • 生物活性
    Description: 4-Methoxy-5- hydroxycanthin-6-one has anti-inflammatory effect, it can significantly inhibit the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7, it has protective effect on dextran sulfate sodium -induced rat colitis. After oral administration, 4-methoxy-5- hydroxycanthin-6-one (3, 9, and 27 mg/kg) can reduce the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. 5-Hydroxy-4-methoxycanthin-6-one exhibits significant cytotoxic activity against CNE2 cell line.
    Targets: NO | TNF-α | NOS
    In vitro:
    J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1009-12.
    Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity.[Pubmed: 19031238]

    METHODS AND RESULTS:
    A new alkaloid, 4,5-dimethoxy-10-hydroxycanthin-6-one (1), was isolated from the stem of Picrasma quassioides Bennet (Simaroubaceae) together with four known canthin-6-one alkaloids, 8-hydroxycanthin-6-one (2), 4,5-dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), and 3-methylcanthin-5,6-dione (5). Their structures were elucidated on the basis of spectroscopic data. The cytotoxic activity of the canthin-6-one alkaloids was evaluated using human nasopharyngeal carcinoma (CNE2) and human liver cancer (Bel-7402) cell lines.
    CONCLUSIONS:
    Among these isolates, compounds 1-4 exhibited significant cytotoxic activity against CNE2 cell line.
    In vivo:
    Phytomedicine. 2013 Feb 15;20(3-4):319-23.
    In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides.[Pubmed: 23271002 ]
    In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (5-Hydroxy-4-methoxycanthin-6-one,CAN), a natural alkaloid isolated from Picrasma quassioides.
    METHODS AND RESULTS:
    CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
    CONCLUSIONS:
    The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis.
    Planta Med. 2009 Feb;75(2):142-5.
    Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis.[Pubmed: 19085815]

    METHODS AND RESULTS:
    In the present study, we evaluated the effect of 4-methoxy-5-hydroxycanthin-6-one (5-Hydroxy-4-methoxycanthin-6-one, CAN), a natural alkaloid isolated from Picrasma quassioides (D.Don) Benn., on ulcerative colitis induced by dextran sulfate sodium (DSS) in rats in comparison with the positive control drug, sulfasalazine (SASP). Given orally for several days, CAN significantly reduced the severity of colitis and mitigated changes in colon length, colon mucosa myeloperoxidase (MPO) activity, and the level of tumor necrosis factor-alpha (TNF-alpha) in serum. The effect of CAN was similar to that of SASP.
    CONCLUSIONS:
    These results suggest that CAN treatment might be an effective therapeutic intervention against ulcerative colitis induced by DSS.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7552 mL 18.7758 mL 37.5516 mL 75.1033 mL 93.8791 mL
    5 mM 0.751 mL 3.7552 mL 7.5103 mL 15.0207 mL 18.7758 mL
    10 mM 0.3755 mL 1.8776 mL 3.7552 mL 7.5103 mL 9.3879 mL
    50 mM 0.0751 mL 0.3755 mL 0.751 mL 1.5021 mL 1.8776 mL
    100 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.751 mL 0.9388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,9-二甲氧基铁屎米酮; 4,9-Dimethoxycanthin-6-one CFN92128 1270001-72-3 C16H12N2O3 = 280.3 5mg QQ客服:3257982914
    5-羟基-6-铁屎米酮; 5-Hydroxy-canthin-6-one CFN92930 64118-73-6 C14H8N2O2 = 236.23 5mg QQ客服:1457312923
    5-甲氧基铁屎米酮; 5-Methoxycanthin-6-one CFN92362 15071-56-4 C15H10N2O2 = 250.3 5mg QQ客服:2159513211
    苦木西碱Q; Picrasidine Q CFN92205 101219-61-8 C15H10N2O3 = 266.3 10mg QQ客服:1457312923
    5-羟基-4-甲氧基铁屎米酮; 5-Hydroxy-4-methoxycanthin-6-one CFN99846 18110-86-6 C15H10N2O3 = 266.3 5mg QQ客服:3257982914
    4,5-二甲氧基铁屎米酮; 4,5-Dimethoxycanthin-6-one CFN99847 18110-87-7 C16H12N2O3 = 280.3 5mg QQ客服:3257982914

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