Info: Read More
  • 中药标准品生产商,产品定制服务
  • 4,5-二甲氧基铁屎米酮

    4,5-Dimethoxycanthin-6-one

    4,5-二甲氧基铁屎米酮
    产品编号 CFN99847
    CAS编号 18110-87-7
    分子式 = 分子量 C16H12N2O3 = 280.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Picrasma quassioides (D.Don) Benn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 1mg QQ客服:1413575084
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 5mg QQ客服:1413575084
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 10mg QQ客服:1413575084
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Institute of Cancer Research (United Kingdom)
  • University of Oslo (Norway)
  • Universita' Degli Studi Di Cagliari (Italy)
  • MTT Agrifood Research Finland (Finland)
  • Hamdard University (India)
  • National Chung Hsing University (Taiwan)
  • Utrecht University (Netherlands)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Donald Danforth Plant Science Center (USA)
  • National Cancer Center Research Institute (Japan)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Queensland (Australia)
  • Julius Kühn-Institut (Germany)
  • Heidelberg University (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J Acupunct2020, 37:104-121
  • Food Research International2016, 106-113
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Foods.2020, 9(10):1348.
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • Int J Mol Sci.2019, 20(8):E1855
  • J Nat Med.2017, 71(2):380-388
  • Heliyon.2022, e12337.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Biomedicines.2020, 8(11):486.
  • Pharmaceutics.2021, 13(11):1839.
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Molecules.2020 ,25(16):3697.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • BMB Rep.2018, 51(5):249-254
  • Horticulture Research2020, 7:111.
  • bioRxiv - Molecular Biology2023, 535548.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • ...
  • 生物活性
    Description: 4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one has a strong inhibitory effect on cyclic adenosine monophosphate (cAMP) phosphodiesterase. It also shows cytotoxicity against the tumor cell lines, U937 and HepG2.
    Targets: cAMP | Antifection
    In vitro:
    J. Korean Soc. Appl. Biol. Chem.,2009, 52(6):663-7.
    Cytotoxic alkaloids from the wood of Picrasma quassioides.[Reference: WebLink]
    Six alkaloid compounds were isolated from the chloroform soluble fraction of the methanolic extract of the wood of Picrasma quassioides Benn (Simarobaceae) as the cytotoxic components against the tumor cell lines, U937 and HepG2.
    METHODS AND RESULTS:
    The compounds were identified as 4,9-dimethoxy-1-vinyl-γ-carboline (1), 1-carbomethoxy-β-carboline (2), 4,5-Dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), 3-methoxycanthin-5,6-dione (5) and 4,8-dimethoxy-1-vinyl-β-carboline (6) by spectroscopic analysis. Among them, compound 5 showed the most potent cytotoxicity in a dose-dependent manner against the two tumor cell lines.
    CONCLUSIONS:
    This is the first report of the cytotoxic effect of those isolated compounds 1-5 on U937 and HepG2 cell lines.
    Chem Pharm Bull (Tokyo). 1984 May;32(5):1872-7.
    Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related .BETA.-carboline alkaloids.[Reference: WebLink]

    METHODS AND RESULTS:
    Cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitors present in Picrasma quassioides BENN. were identified as 1-methoxycarbonyl-β-carboline, 4,5-Dimethoxycanthin-6-one and 5-hydroxy-4-methoxycanthin-6-one. The structure-inhibitory activity relationships were studied in 31 derivatives of β-carboline, 2 dimeric derivatives of β-carboline and 12 derivatives of canthin-6-one.
    CONCLUSIONS:
    β-Carboline derivatives with a methoxycarbonyl group and canthin-6-one derivatives with a methoxyl group generally had a strong inhibitory effect on cAMP phosphodiesterase.
    Yao Xue Xue Bao,1979, 14(3):167-77.
    Chemical investigation of the alkaloids of Ku-Mu [Picrasma quassioides (D. Don) Benn.[Reference: WebLink]
    Some preparation of the total alkaloids of Ku-Mu (Picrasma quassioides (D. Don) Benn.) was Shown to have antibacterial actiyity in clinical trial. For the exploration of the active principles, the present paper deals with the studies of the alkaloids of this medicinal plant.
    METHODS AND RESULTS:
    From an alcohol extract of heartwood of Ku-Mu seven alkaloids were isolated through silica gel and alumina column chromatography as well as preparative thin layer chromatography. Beside the known alkaloids 1-carbomethoxy-β-carboline (Ⅱ), 4,5-Dimethoxycanthin-6-one (Ⅳ), canthin-6-one (Ⅴ), and 4-methoxy-5-hydroxycanthin-6-one (Ⅵ), three new alkaloids, named Kumujian A, Kumujian G, and Kumujian G, were ident fied as 1-carboethoxy-β-carbotine (Ⅰ), 1-formyl-β-carboline(Ⅲ) and 1-vinyl-4,8-dimethoxy-β-carboline (Ⅶ), respectively. In vitro screening of the above alkaloids demonstrated that 1-carbomethoxy-β-carboline (Ⅱ), 4,5-Dimethoxycanthin-6-one (Ⅳ), 4-methoxy-5-hydroxycanthin-6-one (Ⅵ) and 1-vinyl-4,8-dimethoxy-β-carboline (Ⅶ) exhibited inhibition against Staphylococcus aureus and its drug-resistant strains.
    CONCLUSIONS:
    Tests for the antibacterial activity of three other alkaloids were hampered by scarcity of material.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5676 mL 17.838 mL 35.6761 mL 71.3521 mL 89.1902 mL
    5 mM 0.7135 mL 3.5676 mL 7.1352 mL 14.2704 mL 17.838 mL
    10 mM 0.3568 mL 1.7838 mL 3.5676 mL 7.1352 mL 8.919 mL
    50 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.427 mL 1.7838 mL
    100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.7135 mL 0.8919 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,9-二甲氧基铁屎米酮; 4,9-Dimethoxycanthin-6-one CFN92128 1270001-72-3 C16H12N2O3 = 280.3 5mg QQ客服:215959384
    5-羟基-6-铁屎米酮; 5-Hydroxy-canthin-6-one CFN92930 64118-73-6 C14H8N2O2 = 236.23 5mg QQ客服:2056216494
    5-甲氧基铁屎米酮; 5-Methoxycanthin-6-one CFN92362 15071-56-4 C15H10N2O2 = 250.3 5mg QQ客服:215959384
    苦木西碱Q; Picrasidine Q CFN92205 101219-61-8 C15H10N2O3 = 266.3 10mg QQ客服:3257982914
    5-羟基-4-甲氧基铁屎米酮; 5-Hydroxy-4-methoxycanthin-6-one CFN99846 18110-86-6 C15H10N2O3 = 266.3 5mg QQ客服:215959384
    4,5-二甲氧基铁屎米酮; 4,5-Dimethoxycanthin-6-one CFN99847 18110-87-7 C16H12N2O3 = 280.3 5mg QQ客服:2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产