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  • 豌豆素

    Pisatin

    豌豆素
    产品编号 CFN96000
    CAS编号 20186-22-5
    分子式 = 分子量 C17H14O6 = 314.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Pisum sativum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    豌豆素 CFN96000 20186-22-5 1mg QQ客服:2159513211
    豌豆素 CFN96000 20186-22-5 5mg QQ客服:2159513211
    豌豆素 CFN96000 20186-22-5 10mg QQ客服:2159513211
    豌豆素 CFN96000 20186-22-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Macau University of Science and Technology (China)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Chulalongkorn University (Thailand)
  • University of British Columbia (Canada)
  • Univerzita Karlova v Praze (Czech Republic)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Sci. Rep.2015, 14-23
  • Acta Physiologiae Plantarum2015, 37:1736
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • The Korea Journal of Herbology2016, 29-35
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Vojnosanit Pregl2016, 75(00):391-391
  • Nutrients.2017, 10(1)
  • Molecules.2017, 22(6)
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • FEMS Microbiol Lett.2017, 364(11)
  • Pharm Biol.2017, 55(1):360-366
  • Oncotarget.2017, 8(53):90925-90947
  • PLoS One.2018, 13(11):e0208055
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Nat Prod Sci.2018, 24(2):109-114
  • Mol Cells.2018, 41(8):771-780
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Front Neurosci.2019, 13:1091
  • Int J Mol Sci.2019, 20(16):E4015
  • J Med Food.2019, 22(10):1067-1077
  • Anal Biochem.2019, 569:10-15
  • Food and Chemical Toxicology2020, 111221
  • ...
  • 生物活性
    Description: Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
    Targets: P450 (e.g. CYP17) | NADPH-oxidase
    In vitro:
    Molecules. 2014 Dec 23;20(1):24-34.
    EDTA a novel inducer of pisatin, a phytoalexin indicator of the non-host resistance in peas.[Pubmed: 25546618]
    Pea pod endocarp suppresses the growth of an inappropriate fungus or non-pathogen by generating a "non-host resistance response" that completely suppresses growth of the challenging fungus within 6 h. Most of the components of this resistance response including Pisatin production can be elicited by an extensive number of both biotic and abiotic inducers. Thus this phytoalexin serves as an indicator to be used in evaluating the chemical properties of inducers that can initiate the resistance response. Many of the Pisatin inducers are reported to interact with DNA and potentially cause DNA damage.
    METHODS AND RESULTS:
    Here we propose that EDTA (ethylenediaminetetraacetic acid) is an elicitor to evoke non-host resistance in plants. EDTA is manufactured as a chelating agent, however at low concentration it is a strong elicitor, inducing the phytoalexin Pisatin, cellular DNA damage and defense-responsive genes. It is capable of activating complete resistance in peas against a pea pathogen. Since there is also an accompanying fragmentation of pea DNA and alteration in the size of pea nuclei, the potential biochemical insult as a metal chelator may not be its primary action.
    CONCLUSIONS:
    The potential effects of EDTA on the structure of DNA within pea chromatin may assist the transcription of plant defense genes.
    Mol Plant Microbe Interact. 2004 Jul;17(7):798-804.
    Introduction of plant and fungal genes into pea (Pisum sativum L.) hairy roots reduces their ability to produce pisatin and affects their response to a fungal pathogen.[Pubmed: 15242174]
    Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.). Previous studies have identified two enzymes apparently involved in the synthesis of this phytoalexin, isoflavone reductase (IFR), which catalyzes an intermediate step in Pisatin biosynthesis, and (+)6a-hydroxymaackiain 3-O-methyltransferase (HMM), an enzyme catalyzing the terminal step.
    METHODS AND RESULTS:
    To further evaluate the involvement of these enzymes in Pisatin biosynthesis, sense- and antisense-oriented cDNAs of Ifr and Hmm fused to the 35s CaMV promoter, and Agrobacterium rhizogenes, were used to produce transgenic pea hairy root cultures. PDA, a gene encoding Pisatin demethylating activity (pda) in the pea-pathogenic fungus Nectria haematococca, also was used in an attempt to reduce Pisatin levels. Although hairy root tissue with either sense or antisense Ifr cDNA produced less Pisatin, the greatest reduction occurred with sense or antisense Hmm cDNA. The reduced Pisatin production in these lines was associated with reduced amounts of Hmm transcripts, HMM protein, and HMM enzyme activity. Hairy roots containing the PDA gene also produced less Pisatin. To evaluate the role of Pisatin in disease resistance, the virulence of N. haematococca on the transgenic roots that produced the lowest levels of Pisatin was tested.
    CONCLUSIONS:
    Hairy roots expressing antisense Hmm were more susceptible than the control hairy roots to isolates of N. haematococca that are either virulent or nonvirulent on wild-type pea plants. This appears to be the first case of producing transgenic plant tissue with a reduced ability to produce a phytoalexin and demonstrating that such tissue is less resistant to fungal infection: these results support the hypothesis that phytoalexin production is a disease resistance mechanism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pterocarpadiol C; Pterocarpadiol C CFN89483 2055882-22-7 C16H14O7 = 318.27 5mg QQ客服:2932563308
    Pterocarpadiol B; Pterocarpadiol B CFN89481 2055882-20-5 C16H14O6 = 302.27 5mg QQ客服:2159513211
    Pterocarpadiol A; Pterocarpadiol A CFN89482 2055882-21-6 C16H12O7 = 316.26 5mg QQ客服:1148253675
    巴西苏木素; 苏枋精; Brazilin CFN98711 474-07-7 C16H14O5 = 286.3 20mg QQ客服:2159513211
    苏木精; Hematoxylin CFN96490 517-28-2 C16H14O6 = 302.28 20mg QQ客服:1413575084
    3,9-二羟基紫檀碱; 3,9-Dihydroxypterocarpan CFN97043 61135-91-9 C15H12O4 = 256.3 5mg QQ客服:3257982914
    异美迪紫檀素; Isomedicarpin CFN97226 74560-05-7 C16H14O4 = 270.3 5mg QQ客服:215959384
    美迪紫檀素; Medicarpin CFN98411 32383-76-9 C16H14O4 = 270.3 5mg QQ客服:1148253675
    美迪紫檀素-3-O-葡萄糖苷; Medicarpin 3-O-glucoside CFN89498 52766-70-8 C22H24O9 = 432.42 5mg QQ客服:1413575084
    Glycinol; Glycinol CFN95122 69393-95-9 C15H12O5 = 272.3 5mg QQ客服:2159513211

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