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  • 马卡因; 高丽槐素

    Maackiain

    马卡因; 高丽槐素
    产品编号 CFN99746
    CAS编号 19908-48-6
    分子式 = 分子量 C16H12O5 = 284.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The flowers of Maackia amurensis Rupr.et Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    马卡因; 高丽槐素 CFN99746 19908-48-6 10mg QQ客服:3257982914
    马卡因; 高丽槐素 CFN99746 19908-48-6 20mg QQ客服:3257982914
    马卡因; 高丽槐素 CFN99746 19908-48-6 50mg QQ客服:3257982914
    马卡因; 高丽槐素 CFN99746 19908-48-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Amity University (India)
  • Washington State University (USA)
  • Semmelweis Unicersity (Hungary)
  • Melbourne University (Australia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Univerzita Karlova v Praze (Czech Republic)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Aarhus University (Denmark)
  • Monash University Sunway Campus (Malaysia)
  • Sanford Burnham Medical Research Institute (USA)
  • Anna University (India)
  • Yale University (USA)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Acta horticulturae2017, 1158:257-268
  • PLoS One.2017, 12(8):e0181191
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Molecules.2017, 22(11)
  • Universidade Estadual Paulista2017, 42785
  • J Nat Prod.2017, 80(4):854-863
  • Int. J. of Food Properties2017, S108-S118
  • Nutrients.2018, 10(12):E1998
  • PLoS One.2018, 13(3):e0193386
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • J Sep Sci.2018, 41(7):1682-1690
  • Saf Health Work.2019, 10(2):196-204
  • Biomed Pharmacother.2019, 116:108987
  • Nutrients.2019, 12(1):E40
  • Nutr Res Pract2019, 13:e45
  • Molecules.2019, 24(24),4583
  • J Ethnopharmacol.2019, 241:112025
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • J Mater Chem B.2019, 7(39):5896-5919
  • Comput Biol Chem.2019, 83:107096
  • Biomolecules.2019, 9(11):E696
  • Food and Chemical Toxicology2020, 111221
  • ...
  • 生物活性
    Description: Maackiain is an antimicrobial compound (phytoalexins), it has anticancer effects, it induces apoptosis and growth suppression. Maackiain also shows strong larvicidal activity (LC50 = 21.95 ± 1.34 ug/mL).
    Targets: Antifection
    In vitro:
    Exp Parasitol. 2015 Jun;153:160-4.
    Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.[Pubmed: 25819294]

    METHODS AND RESULTS:
    The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines. Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 µg/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC₅₀ = 34.90 ± 1.27 µg/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC₅₀ = 17.5 ± 1.87 µg/mL) and maackiain showed to be a strong larvicidal compound (LC₅₀ = 21.95 ± 1.34 µg/mL).
    CONCLUSIONS:
    This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector.
    Oncol Rep. 2004 Dec;12(6):1183-8.
    Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.[Pubmed: 15547735]

    METHODS AND RESULTS:
    We have investigated the effects of maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) on DNA of human promyelotic HL-60 leukemia cells. It was found that extent of induction of apoptosis by maackiain was larger than that by trifolirhizin in human leukemia HL-60 cells. Morphological changes showing apoptotic bodies were observed in the HL-60 cells treated with maackiain and trifolirhizin. The fragmentations of DNA by maackiain and trifolirhizin to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in the HL-60 cells.
    CONCLUSIONS:
    The data of the present study show that the suppressions by maackiain and trifolrhizin of growth of the HL-60 cells result from the induction of apoptosis by these compounds, and that the extent of growth suppression and induction of apoptosis by maackiain was greater than that by the glycoside (trifolirhizin).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5178 mL 17.5889 mL 35.1778 mL 70.3556 mL 87.9446 mL
    5 mM 0.7036 mL 3.5178 mL 7.0356 mL 14.0711 mL 17.5889 mL
    10 mM 0.3518 mL 1.7589 mL 3.5178 mL 7.0356 mL 8.7945 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4071 mL 1.7589 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8794 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-Hydroxy-8,9-methylenedioxypterocarpene; 3-Hydroxy-8,9-methylenedioxypterocarpene CFN96063 59901-98-3 C16H10O5 = 282.3 5mg QQ客服:1413575084
    马卡因; 高丽槐素; Maackiain CFN99746 19908-48-6 C16H12O5 = 284.27 20mg QQ客服:2932563308
    红车轴草根甙; 三叶豆紫檀苷; Trifolirhizin CFN97160 6807-83-6 C22H22O10 = 446.4 20mg QQ客服:1413575084
    6alpha-羟基高丽槐素; 6alpha-Hydroxymaackiain CFN96037 61218-44-8 C16H12O6 = 300.3 5mg QQ客服:2932563308
    豌豆素; Pisatin CFN96000 20186-22-5 C17H14O6 = 314.3 5mg QQ客服:2932563308
    Sophoracarpan A ; Sophoracarpan A CFN96672 1674359-82-0 C17H16O5 = 300.31 5mg QQ客服:1413575084
    Sophoracarpan B ; Sophoracarpan B CFN96671 1674359-84-2 C17H14O6 = 314.30 5mg QQ客服:2932563308
    1,11B-二氢-11B-羟基美迪紫檀素; 1,11b-Dihydro-11b-hydroxymedicarpin CFN96002 210537-04-5 C16H16O5 = 288.3 5mg QQ客服:3257982914
    1,11B-二氢-11B-羟基高丽槐素; 1,11b-Dihydro-11b-hydroxymaackiain CFN96003 210537-05-6 C16H14O6 = 302.3 5mg QQ客服:3257982914
    Pterocarpadiol D; Pterocarpadiol D CFN89484 2055882-23-8 C16H16O6 = 304.29 5mg QQ客服:2159513211

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