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  • 红车轴草根甙; 三叶豆紫檀苷

    Trifolirhizin

    红车轴草根甙; 三叶豆紫檀苷
    产品编号 CFN97160
    CAS编号 6807-83-6
    分子式 = 分子量 C22H22O10 = 446.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Flavonoids
    植物来源 The roots of Sophora flavescens L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    红车轴草根甙; 三叶豆紫檀苷 CFN97160 6807-83-6 10mg QQ客服:2159513211
    红车轴草根甙; 三叶豆紫檀苷 CFN97160 6807-83-6 20mg QQ客服:2159513211
    红车轴草根甙; 三叶豆紫檀苷 CFN97160 6807-83-6 50mg QQ客服:2159513211
    红车轴草根甙; 三叶豆紫檀苷 CFN97160 6807-83-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • Sapienza University of Rome (Italy)
  • University of Hertfordshire (United Kingdom)
  • National Cancer Institute (USA)
  • FORTH-IMBB (Greece)
  • University of British Columbia (Canada)
  • Utrecht University (Netherlands)
  • Lodz University of Technology (Poland)
  • Agricultural Research Organization (ARO) (Israel)
  • Chiang Mai University (Thailand)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Periyar University (India)
  • University of Minnesota (USA)
  • University of Lodz (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Breast Cancer.2015, 18(2):112-118
  • Phytomedicine.2015, 22(11):1027-36
  • J Pharm Biomed Anal.2016, 129:50-59
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Pharm Anal.2016, 6(6):363-373
  • Sci Rep. 2017, 12953(7)
  • Int J Anal Chem.2017, 2017:1254721
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Sci Rep.2017, 7:40345
  • Int. J. of Food Properties2017, S108-S118
  • BMC Complement Altern Med.2018, 18(1):221
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Int J Mol Sci.2018, 19(9):E2825
  • Molecules.2018, 23(10):E2638
  • Sci Rep.2018, 8(1):12970
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Int J Mol Sci.2019, 21(1):E265
  • Food Chem.2019, 290:286-294
  • J Food Biochem.2019, 43(9):e12970
  • TCI CO.2019, US20190151281A1
  • Plos One.2020, 10.1371
  • Neurochem Int.2020, 133:104629
  • ...
  • 生物活性
    Description: Trifolirhizin possesses potential anti-inflammatory and anti-cancer activities, it inhibits acetylcholine mediated airway smooth muscle (ASM) contraction or directly relaxes pre-contracted ASM independent of β 2 -adrenoceptors. Trifolirhizin may be a a candidate as skin-whitening agents, it exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis.
    Targets: Adrenergic Receptor | COX | TNF-α | IL Receptor
    In vitro:
    J Agric Food Chem. 2009 Jun 10;57(11):4580-5.
    Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots.[Pubmed: 19402641 ]
    Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of Sophora flavescens, and its chemical structure was confirmed by (1)H and (13)C NMR and MS spectra.
    METHODS AND RESULTS:
    Its anti-inflammatory activity was examined in lipopolysaccharide (LPS)-stimulated mouse J774A.1 macrophages. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells.
    CONCLUSIONS:
    These results suggest that trifolirhizin possesses potential anti-inflammatory and anticancer activities.
    Biol Pharm Bull. 2008 Jan;31(1):154-8.
    Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis.[Pubmed: 18175961]
    Previously, it was reported that some prenylated flavonoids contained in the dichloromethane fraction of the ethanolic extract of Sophora flavescens, such as kuraridin, sophoraflavanone G, kurarinone, and kushenol F, are tyrosinase inhibitors; however, based on the level of these inhibitors in the extract, its inhibitory effect on tyrosinase activity was higher than expected. This has led us to further investigate other possible constituents that may contribute to the extract's strong inhibitory activity.
    METHODS AND RESULTS:
    The results of this study indicate that kurarinol (1), kuraridinol (2), and trifolirhizin (3), from the ethyl acetate fraction of Sophora extract, can inhibit tyrosinase activity. Compared with kojic acid (16.22+/-1.71 microM), compounds 1-3 possessed potent tyrosinase inhibitory activity with IC(50) values of 8.60+/-0.51, 0.88+/-0.06, and 506.77+/-4.94 microM, respectively. These three compounds were further tested for their inhibitory effects on melanogenesis. In cultured B16 melanoma cells, 1-3 markedly inhibited (>50%) melanin synthesis at 50 microM.
    CONCLUSIONS:
    This is the first study indicating that 1-3 exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2401 mL 11.2007 mL 22.4014 mL 44.8029 mL 56.0036 mL
    5 mM 0.448 mL 2.2401 mL 4.4803 mL 8.9606 mL 11.2007 mL
    10 mM 0.224 mL 1.1201 mL 2.2401 mL 4.4803 mL 5.6004 mL
    50 mM 0.0448 mL 0.224 mL 0.448 mL 0.8961 mL 1.1201 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.448 mL 0.56 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    美迪紫檀素; Medicarpin CFN98411 32383-76-9 C16H14O4 = 270.3 5mg QQ客服:3257982914
    美迪紫檀素-3-O-葡萄糖苷; Medicarpin 3-O-glucoside CFN89498 52766-70-8 C22H24O9 = 432.42 5mg QQ客服:1413575084
    Glycinol; Glycinol CFN95122 69393-95-9 C15H12O5 = 272.3 5mg QQ客服:215959384
    6alpha-羟基美迪紫檀素; 6alpha-Hydroxymedicarpin CFN96029 61135-92-0 C16H14O5 = 286.3 5mg QQ客服:2159513211
    3,9-二甲氧基紫檀碱; 高紫檀素; Homopterocarpin CFN97720 606-91-7 C17H16O4 = 284.31 5mg QQ客服:2932563308
    (-)-Variabilin; (-)-Variabilin CFN97945 370102-93-5 C17H16O5 = 300.3 5mg QQ客服:2159513211
    3-羟基-9,10-二甲氧基紫檀烷; Methylnissolin CFN90838 733-40-4 C17H16O5 = 300.3 10mg QQ客服:1413575084
    美迪紫檀苷; Methylnissolin-3-O-glucoside CFN93199 94367-42-7 C23H26O10 = 462.5 20mg QQ客服:2159513211
    3-Hydroxy-8,9-methylenedioxypterocarpene; 3-Hydroxy-8,9-methylenedioxypterocarpene CFN96063 59901-98-3 C16H10O5 = 282.3 5mg QQ客服:1413575084
    马卡因; 高丽槐素; Maackiain CFN99746 19908-48-6 C16H12O5 = 284.27 20mg QQ客服:2932563308

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