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    Glycinol

    Glycinol

    Glycinol
    产品编号 CFN95122
    CAS编号 69393-95-9
    分子式 = 分子量 C15H12O5 = 272.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Derris robusta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Glycinol CFN95122 69393-95-9 1mg QQ客服:2932563308
    Glycinol CFN95122 69393-95-9 5mg QQ客服:2932563308
    Glycinol CFN95122 69393-95-9 10mg QQ客服:2932563308
    Glycinol CFN95122 69393-95-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wollongong (Australia)
  • University of Amsterdam (Netherlands)
  • Utrecht University (Netherlands)
  • Nanjing University of Chinese Medicine (China)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Maryland School of Medicine (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Seoul National University of Science and Technology (Korea)
  • University of Malaya (Malaysia)
  • CSIRO - Agriculture Flagship (Australia)
  • University of Queensland (Australia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Tokyo Woman's Christian University (Japan)
  • University of Pretoria (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Int J Mol Med.2015, 35(5):1237-45
  • Arch Pharm Res.2015, 38(6):1080-9
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • PLoS One.2018, 13(3):e0193386
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Phytochemistry2018, 15:83-92
  • Cell.2018, 172(1-2):249-261
  • BMC Plant Biol.2018, 18(1):122
  • Int J Mol Sci.2018, 19(9):E2528
  • Oncology Letters2018, 4690-4696
  • Sci Rep.2018, 8(1)
  • Virulence.2018, 9(1):588-603
  • J Pharm Biomed Anal.2019, 164:119-127
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Exp Ther Med.2019, 18(6):4388-4396
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2019, 24(11):E2102
  • Med Sci Monit.2019, 25:9499-9508
  • New Journal of Chemistry2019, 43:12538-12547
  • Planta Med.2019, 85(9-10):766-773
  • Sci Rep.2019, 9:19059
  • ...
  • 生物活性
    Description: Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
    In vitro:
    Regen Med. 2017 Jul;12(5):513-524.
    Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.[Pubmed: 28718749 ]
    Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
    METHODS AND RESULTS:
    The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling.
    CONCLUSIONS:
    The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.
    In vivo:
    Eksp Klin Farmakol. 2010 Oct;73(10):21-4.
    [Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].[Pubmed: 21254509]
    New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized.
    METHODS AND RESULTS:
    Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity.
    CONCLUSIONS:
    Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6724 mL 18.3621 mL 36.7242 mL 73.4484 mL 91.8105 mL
    5 mM 0.7345 mL 3.6724 mL 7.3448 mL 14.6897 mL 18.3621 mL
    10 mM 0.3672 mL 1.8362 mL 3.6724 mL 7.3448 mL 9.1811 mL
    50 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.469 mL 1.8362 mL
    100 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.7345 mL 0.9181 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,11B-二氢-11B-羟基美迪紫檀素; 1,11b-Dihydro-11b-hydroxymedicarpin CFN96002 210537-04-5 C16H16O5 = 288.3 5mg QQ客服:215959384
    1,11B-二氢-11B-羟基高丽槐素; 1,11b-Dihydro-11b-hydroxymaackiain CFN96003 210537-05-6 C16H14O6 = 302.3 5mg QQ客服:1148253675
    Pterocarpadiol D; Pterocarpadiol D CFN89484 2055882-23-8 C16H16O6 = 304.29 5mg QQ客服:3257982914
    Pterocarpadiol C; Pterocarpadiol C CFN89483 2055882-22-7 C16H14O7 = 318.27 5mg QQ客服:215959384
    Pterocarpadiol B; Pterocarpadiol B CFN89481 2055882-20-5 C16H14O6 = 302.27 5mg QQ客服:1413575084
    Pterocarpadiol A; Pterocarpadiol A CFN89482 2055882-21-6 C16H12O7 = 316.26 5mg QQ客服:1413575084
    巴西苏木素; 苏枋精; Brazilin CFN98711 474-07-7 C16H14O5 = 286.3 20mg QQ客服:2159513211
    苏木精; Hematoxylin CFN96490 517-28-2 C16H14O6 = 302.28 20mg QQ客服:1413575084
    3,9-二羟基紫檀碱; 3,9-Dihydroxypterocarpan CFN97043 61135-91-9 C15H12O4 = 256.3 5mg QQ客服:2932563308
    异美迪紫檀素; Isomedicarpin CFN97226 74560-05-7 C16H14O4 = 270.3 5mg QQ客服:215959384

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