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  • Dehydrogeijerin

    Dehydrogeijerin

    Dehydrogeijerin
    产品编号 CFN89248
    CAS编号 16850-91-2
    分子式 = 分子量 C15H14O4 = 258.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Dehydrogeijerin CFN89248 16850-91-2 1mg QQ客服:215959384
    Dehydrogeijerin CFN89248 16850-91-2 5mg QQ客服:215959384
    Dehydrogeijerin CFN89248 16850-91-2 10mg QQ客服:215959384
    Dehydrogeijerin CFN89248 16850-91-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • National Cancer Institute (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Center for protein Engineering (CIP) (Belgium)
  • FORTH-IMBB (Greece)
  • Kamphaengphet Rajabhat University (Thailand)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Periyar University (India)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Vigo (Spain)
  • Michigan State University (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • Auburn University2015, 1-58
  • University of Limpopo2016, 1-237
  • J Ethnopharmacol.2016, 194:219-227
  • Mediators Inflamm.2016, 2016:7216912
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Eur J Pharm Sci.2016, 94:33-45
  • Free Radic Biol Med.2016, 97:307-319
  • Phytochemistry.2017, 141:162-170
  • Food Chem.2017, 221:1135-1144
  • Journal of Functional Foods2017, 30:30-38
  • Phytochemistry Letters2017, 449-455
  • Cytotechnology.2017, 69(5):765-773
  • J Nat Med.2017, 71(2):380-388
  • Front Pharmacol.2017, 8:205
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Nutrients.2019, 12(1):E40
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Molecules.2019, 24(19):E3417
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Front Plant Sci.2020, 10:1705
  • ...
  • 生物活性
    Description: Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of inflammatory disease.
    Targets: NO | COX | NOS | MAPK
    In vitro:
    Int Immunopharmacol. 2012 Dec;14(4):734-9.
    Anti-inflammatory effects of dehydrogeijerin in LPS-stimulated murine macrophages.[Pubmed: 23102664]

    METHODS AND RESULTS:
    In this study, we investigated whether Heracleum (H) moellendorffii Hance-derived Dehydrogeijerin and geijerin could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines, Raw 264.7 cells. Dehydrogeijerin reduced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production from LPS-stimulated Raw 264.7 cells, but on the other hand, geijerin did not reduce NO production. Dehydrogeijerin, unlike geijerin, has a double bond at C2'-C3' with an oxo function at C1'. Pre-treatment of Raw 264.7 cells with Dehydrogeijerin reduced the production of cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines. These inhibitory effects were associated with decreases in the phosphorylation of mitogen-activated protein (MAP) kinases.
    CONCLUSIONS:
    Our results indicate that Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that Dehydrogeijerin could be a potential candidate for the treatment of inflammatory disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8719 mL 19.3596 mL 38.7192 mL 77.4383 mL 96.7979 mL
    5 mM 0.7744 mL 3.8719 mL 7.7438 mL 15.4877 mL 19.3596 mL
    10 mM 0.3872 mL 1.936 mL 3.8719 mL 7.7438 mL 9.6798 mL
    50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.5488 mL 1.936 mL
    100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.968 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    当归醇M; Angelol M CFN95060 1092952-64-1 C20H24O7 = 376.4 5mg QQ客服:215959384
    当归醇B; Angelol B CFN91000 83156-04-1 C20H24O7 = 376.4 10mg QQ客服:1148253675
    当归醇K; Angelol K CFN80136 169736-93-0 C20H24O7 = 376.15 5mg QQ客服:3257982914
    当归醇G; Angelol G CFN92988 83199-38-6 C20H24O7 = 376.40 10mg QQ客服:1413575084
    当归醇H; Angelol H CFN91925 83247-73-8 C20H24O7 = 376.40 5 mg QQ客服:2159513211
    飞龙掌血内酯; Toddaculine CFN92733 4335-12-0 C16H18O4 = 274.3 5mg QQ客服:2932563308
    飞龙掌血内酯; Toddalolactone CFN90247 483-90-9 C16H20O6 = 308.33 20mg QQ客服:3257982914
    (-)-飞龙掌血烯醇内酯; (-)-Toddanol CFN92513 77715-99-2 C16H18O5 = 290.3 5mg QQ客服:2932563308
    飞龙掌血内酯酮; Toddanone CFN92514 77636-08-9 C16H18O5 = 290.3 5mg QQ客服:2159513211
    5-Methoxysuberenone; 5-Methoxysuberenone CFN92732 85011-58-1 C15H14O5 = 274.3 5mg QQ客服:1413575084

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