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  • 白花前胡醇

    Peucedanol

    白花前胡醇
    产品编号 CFN99738
    CAS编号 28095-18-3
    分子式 = 分子量 C15H18O5 = 278.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Peucedanum praeruptorum Dunn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白花前胡醇 CFN99738 28095-18-3 1mg QQ客服:1457312923
    白花前胡醇 CFN99738 28095-18-3 5mg QQ客服:1457312923
    白花前胡醇 CFN99738 28095-18-3 10mg QQ客服:1457312923
    白花前胡醇 CFN99738 28095-18-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Almansora University (Egypt)
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  • University of Minnesota (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • Molecules.2019, 24(24),4583
  • J. of Agricultural Science2015, 1916-9760
  • Nutrients.2021, 13(12):4364.
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Antioxidants (Basel).2021, 10(1):112.
  • Free Radic Biol Med.2021, 166:104-115.
  • Int J Mol Sci.2021, 22(2):770.
  • Institute of Food Science & Technology2021, 18 December.
  • Int Immunopharmacol.2023, 125:111175.
  • Food Funct.2020, 11(2):1322-1333.
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • Molecules.2021, 26(19):6032.
  • United States Patent Application2020, 20200038363
  • Applied Biological Chem. 2020, 26(63).
  • Indian J. of Experimental Bio.2020, 9(58).
  • J Pharmaceut Biomed2020, 182:113110
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Molecules2022, 27(12):3824.
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • J of Physics Conference Series2019, 1349(1)
  • ...
  • 生物活性
    Description: (R)-peucedanol has radical scavenging on 1,1-diphenyl-2-picrylhydrazyl radical and for inhibition of oxidation of liposome induced by 2,2'-azobis(2-amidinopropane) dihydrochloride, it may have antioxidant activity.
    In vitro:
    Molecules. 2015 Jun 25;20(7):11719-32.
    Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer-An in Vitro Model for Blood-Brain Barrier Permeability.[Pubmed: 26121397]
    Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities.
    METHODS AND RESULTS:
    The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR including umbelliferone (1), osthol (2), scopoletin (3), peucedanol (4), ulopterol (5), angepubebisin (6), psoralen (7), xanthotoxin (8), bergapten (9), isoimperatorin (10), columbianadin (11), and columbianetin acetate (12) with an in vitro model using a MDCK-pHaMDR cell monolayer. The cell monolayer was validated to be suitable for the permeation experiments. The samples' transports were analyzed by high performance liquid chromatography and their apparent permeability coefficients (Papp) were calculated. According to the Papp value, most coumarins could be characterized as well-absorbed compounds except for 4, 10 and 11 which were moderately absorbed ones, in concentration-dependent and time-dependent manners. The results of P-glycoprotein (P-gp) inhibitor (verapamil) experiments showed that the transport of coumarin 4 was affected by the transport protein P-gp. Sigmoid functions between permeability log(Papp AP-BL*MW0.5) and log D (at pH 7.4) were established to analyze the structure-activity relationship of coumarins.
    CONCLUSIONS:
    The results provide useful information for discovering the substance basis for the central nervous system activities of APR, and predicting the permeability of other coumarins through BBB.
    J Agric Food Chem. 2003 Aug 27;51(18):5255-61.
    Antioxidant compounds from the leaves of Peucedanum japonicum thunb.[Pubmed: 12926867]
    Seventeen compounds were isolated from the n-butanol soluble fraction of the leaves of Peucedanum japonicum Thunb.
    METHODS AND RESULTS:
    On the basis of MS and various NMR spectroscopic techniques, the structures of the isolated compounds were determined as isoquercitrin (1), rutin (2), 3-O-caffeoylquinic acid (3), 4-O-caffeoylquinic acid (4), 5-O-caffeoylquinic acid (5), cnidioside A (6), praeroside II (7), praeroside III (8), apterin (9), esculin (10), (R)-Peucedanol (11), (R)-Peucedanol 7-O-beta-d-glucopyranoside (12), l-tryptophan (13), uracil (14), guanosine (15), uridine (16), and thymidine (17). All compounds except 11 and 12 were isolated for the first time from P. japonicum. Several isolated compounds were quantified by high-performance liquid chromatography analysis. In addition, all isolated compounds were examined for radical scavenging on 1,1-diphenyl-2-picrylhydrazyl radical and for inhibition of oxidation of liposome induced by 2,2'-azobis(2-amidinopropane)dihydrochloride.
    CONCLUSIONS:
    Compounds 2-5 were found to be the major potent constituents, which contribute to the antioxidant activity of P. japonicum leaves.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
    5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
    10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
    100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    软木花椒素; Suberosin CFN98985 581-31-7 C15H16O3 = 244.3 20mg QQ客服:215959384
    Dehydrogeijerin; Dehydrogeijerin CFN89248 16850-91-2 C15H14O4 = 258.27 5mg QQ客服:215959384
    Hopeyhopin; Hopeyhopin CFN89250 63975-56-4 C15H14O5 = 274.27 5mg QQ客服:2056216494
    6-(1,2-二羟基-3-甲基-3-丁烯基)-7-甲氧基-2H-1-苯并吡喃-2-酮; Thamnosmonin CFN96622 60094-90-8 C15H16O5 = 276.28 5mg QQ客服:2159513211
    白花前胡醇; Peucedanol CFN99738 28095-18-3 C15H18O5 = 278.30 5mg QQ客服:2159513211
    (R)-白花前胡醇 3'-O-beta-D-吡喃葡萄糖苷; Peucedanol 3'-O-glucoside CFN89411 65891-61-4 C20H26O10 = 426.41 5mg QQ客服:2056216494
    (R)-白花前胡醇 7-O-beta-D-吡喃葡萄糖苷; Peucedanol 7-O-glucoside CFN89412 65853-04-5 C20H26O10 = 426.41 5mg QQ客服:3257982914
    Peujaponiside; Peujaponiside CFN93412 155740-16-2 C25H34O14 = 558.5 5mg QQ客服:2056216494
    当归醇A; Angelol A CFN90999 19625-17-3 C20H24O7 = 376.4 10mg QQ客服:1457312923
    当归醇M; Angelol M CFN95060 1092952-64-1 C20H24O7 = 376.4 5mg QQ客服:3257982914

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