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  • 2,5-二甲基-7-羟基色酮

    Altechromone A

    2,5-二甲基-7-羟基色酮
    产品编号 CFN89130
    CAS编号 38412-47-4
    分子式 = 分子量 C11H10O3 = 190.19
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The metabolites of Alternaria brassicicola ML-P08.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,5-二甲基-7-羟基色酮 CFN89130 38412-47-4 1mg QQ客服:2159513211
    2,5-二甲基-7-羟基色酮 CFN89130 38412-47-4 5mg QQ客服:2159513211
    2,5-二甲基-7-羟基色酮 CFN89130 38412-47-4 10mg QQ客服:2159513211
    2,5-二甲基-7-羟基色酮 CFN89130 38412-47-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

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  • Max Rubner-Institut (MRI) (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2019, 244:112074
  • Research Square2021, 10.21203.
  • Sci Rep. 2018, 1-9
  • Univerzita Karlova2022, 228192.
  • Oxid Med Cell Longev2019, 9056845:13
  • Oncotarget.2016, 8(51):88386-88400
  • Appl. Sci. 2021, 11(22),10569
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  • Front Pharmacol.2021, 12:607403.
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  • ...
  • 生物活性
    Description: Altechromone A has antimicrobial activity, it is active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 ug/ml, respectively.
    Targets: Antifection
    In vitro:
    J Nat Prod. 2007 Jan;70(1):114-7.
    Cytotoxic benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua.[Pubmed: 17253861 ]

    METHODS AND RESULTS:
    Two new benzo[j]fluoranthene-based secondary metabolites named daldinone C (1) and daldinone D (2), along with two known metabolites, Altechromone A and (4S)-5,8-dihydroxy-4-methoxy-alpha-tetralone, were isolated from the CHCl3/MeOH (1:1) extract of a solid culture of the endophyte Hypoxylon truncatum IFB-18 harbored inside the symptomless stem tissue of Artemisia annua. The structures of the new compounds were elucidated by MS and 1D and 2D NMR spectra and by X-ray diffraction analysis. Their absolute configurations were determined unambiguously by a combination of their CD data and the established exciton chirality rule.
    CONCLUSIONS:
    Compounds 1 and 2 were substantially cytotoxic against SW1116 cells, with IC50 values of 49.5 and 41.0 microM, respectively, comparable to that (37.0 microM) of 5-fluorouracil. The biosynthetic pathway for 1 and 2 was postulated with the natural occurrence of benzo[j]fluoranthene analogues discussed in brief.
    World Journal of Microbiology & Biotechnology, 2009, 25(9):1677-1683.
    Bioactive metabolites from Alternaria brassicicola ML-P08, an endophytic fungus residing in Malus halliana[Reference: WebLink]

    METHODS AND RESULTS:
    A total of 48 strains were isolated from the normal tissues of Malus halliana and the EtOAc extracts of their cultures were subjected to primary antimicrobial screening against four test bacteria and three fungi. As a result, 22 strains exhibited antimicrobial activity against at least one test microbe. Among them, Alternaria brassicicola ML-P08 showing strong activity (MICs: 0.31–2.50 mg/ml) was selected for further investigation on its secondary metabolites. Bioassay-guided fractionation of the EtOAc extract of its liquid culture afforded seven compounds, which were identified as alternariol (1), alternariol 9-methyl ether (2), Altechromone A (3), herbarin A (4), cerevisterol (5), 3β,5α-dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (6) and 3β-hydroxy-(22E,24R)-ergosta-5,8,22-trien-7-one (7), respectively, by spectral means (MS, IR, 1H- and 13C-NMR).
    CONCLUSIONS:
    In vitro antimicrobial assay showed that compound 3 was substantially active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 μg/ml, respectively. Compound 4 also showed pronounced antifungal activity against Trichophyton rubrum and C. albicans with MICs of both 15.6 μg/ml. In addition, compound 1 exhibited strong xanthine oxidase inhibitory activity with the IC50 of 15.5 μM, comparable to that of positive control, allopurinol (IC50: 10.7 μM).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2579 mL 26.2895 mL 52.579 mL 105.158 mL 131.4475 mL
    5 mM 1.0516 mL 5.2579 mL 10.5158 mL 21.0316 mL 26.2895 mL
    10 mM 0.5258 mL 2.6289 mL 5.2579 mL 10.5158 mL 13.1447 mL
    50 mM 0.1052 mL 0.5258 mL 1.0516 mL 2.1032 mL 2.6289 mL
    100 mM 0.0526 mL 0.2629 mL 0.5258 mL 1.0516 mL 1.3145 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    番樱桃素; Eugenin CFN90808 480-34-2 C11H10O4 = 206.2 10mg QQ客服:2056216494
    8-Methyleugenitol; 8-Methyleugenitol CFN96198 41682-21-7 C12H12O4 = 220.2 5mg QQ客服:1457312923
    5,7-二羟基-2-(1-甲基乙基)-4H-1-苯并吡喃-4-酮; 5,7-Dihydroxy-2-isopropylchromone CFN97544 96552-59-9 C12H12O4 = 220.2 5mg QQ客服:2159513211
    8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone; 8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone CFN89218 188818-27-1 C19H24O9 = 396.39 5mg QQ客服:1413575084
    6-乙酰基-2,2-二甲基色满酮; 6-Acetyl-2,2-dimethylchroman-4-one CFN97171 68799-41-7 C13H14O3 = 218.3 5mg QQ客服:2056216494
    2,3-二氢-2,5-二甲基-4H-1-苯并吡喃-4-酮 ; 2,5-Dimethylchroman-4-one CFN96894 69687-87-2 C11H12O2 = 176.21 5mg QQ客服:1413575084
    2,5-二甲基-7-羟基色酮; Altechromone A CFN89130 38412-47-4 C11H10O3 = 190.19 5mg QQ客服:2159513211
    羟基甲基氧丙基苯并吡喃酮; Cassiachromone CFN98359 28955-30-8 C13H12O4 = 232.2 5mg QQ客服:3257982914
    dl-Aloesol ; dl-Aloesol CFN96962 104871-04-7 C13H14O4 = 234.25 5mg QQ客服:1457312923
    芦荟苦素; Aloesin CFN91659 30861-27-9 C19H22O9 = 394.37 5mg QQ客服:1457312923

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