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  • 决明子苷

    Cassiaside

    决明子苷
    产品编号 CFN90826
    CAS编号 123914-49-8
    分子式 = 分子量 C20H20O9 = 404.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Cassia obtusifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    决明子苷 CFN90826 123914-49-8 1mg QQ客服:2159513211
    决明子苷 CFN90826 123914-49-8 5mg QQ客服:2159513211
    决明子苷 CFN90826 123914-49-8 10mg QQ客服:2159513211
    决明子苷 CFN90826 123914-49-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Agricultural Research Organization (ARO) (Israel)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Seoul National University (Korea)
  • Charles University in Prague (Czech Republic)
  • University of Oslo (Norway)
  • Institute of Chinese Materia Medica (China)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Madras (India)
  • National Cancer Institute (USA)
  • Chang Gung University (Taiwan)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Ain Shams University (Egypt)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2014, 9(5):1653-9
  • Inflammation2015, 38(1):445-55
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • US20170000760 A12016, 42740
  • Am J Chin Med.2016, 44(6):1255-1271
  • Exp Parasitol.2017, 183:160-166
  • J Ethnopharmacol.2017, 198:205-213
  • Cytotechnology.2017, 69(5):765-773
  • PLoS One.2018, 13(3):e0193386
  • Int J Mol Sci.2018, 19(9):E2528
  • Int J Mol Sci.2018, 19(9):E2681
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • J Nat Prod.2018, 81(4):966-975
  • Front Aging Neurosci.2019, 11:230
  • APMIS.2019, 127(10):688-695
  • J Pharm Biomed Anal.2019, 164:119-127
  • Molecules.2019, 24(16):E2985
  • Molecules.2019, 24(24):E4536
  • Molecules.2019, 24(4):E709
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Journal of Functional Foods2019, 52:430-441
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum. Cassiaside demonstrates significant antimutagenic, and 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging effects. Cassiaside and emodi show mixed-type inhibition against β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1).
    Targets: AChR | BChE
    In vitro:
    Planta Med. 1997 Feb;63(1):11-4.
    In vitro antimutagenic effects of anthraquinone aglycones and naphthopyrone glycosides from Cassia tora.[Pubmed: 9063089 ]
    The antimutagenic activity of a methanol extract of Cassia tora seeds against aflatoxin B1(AFB1) was demonstrated with the Salmonella typhimurium assay.
    METHODS AND RESULTS:
    The numbers of revertants per plate decreased significantly when this extract was added to the assay system using Salmonella typhimurium TA100 and/or TA98. The MeOH extract was then sequentially partitioned with CH2Cl2, n-BuOH and H2O. The CH2Cl2 and n-BuOH fractions possessed antimutagenic activity but the H2O fraction was inactive. Neither the MeOH extract nor its fractions were capable of inhibiting the direct-acting mutagen N-methyl-N'-nitro-N-nitrosoguanidine suggesting that these fractions may prevent the metabolic activation of AFB1 or scavenge the electrophilic intermediate capable of inducing mutations.
    CONCLUSIONS:
    Column chromatography using silica gel yielded pure chrysophanol, chryso-obtusin, and aurantio-obtusin from the CH2Cl2 fraction and cassiaside and rubro-fusarin gentiobioside from the n-BuOH fraction. Each of these compounds demonstrated significant antimutagenic activity.
    Arch Pharm Res. 1994 Dec;17(6):462-6.
    Alaternin, cassiaside and rubrofusarin gentiobioside, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.[Pubmed: 10319159]
    Radical scavenging principles on 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical were isolated from the seeds of Cassia tora L.
    METHODS AND RESULTS:
    Assignments of the 1H- and 13C-NMR data showed the active components to be an anthraquinone, alaternin and two naphthopyrone glycosides, nor-rubrofusarin-6-beta-D-glucoside(Cassiaside) and rubrofusarin-6- -D-gentiobioside. Alaternin showed more potent radical scavenging effect than the others.
    Planta Med. 1989 Jun;55(3):276-80.
    New antihepatotoxic naphtho-pyrone glycosides from the seeds of Cassia tora.[Pubmed: 2740460 ]

    METHODS AND RESULTS:
    Two new naphtho-pyrone glycosides, 9-[(beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]-10- hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(alpha-apiofuranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]- rubrofusarin (6), together with Cassiaside (3) and rubrofusarin-6-beta-gentiobioside (4) were isolated from the seeds of Cassia tora L. Their structures were elucidated on the basis of chemical and spectral data.
    CONCLUSIONS:
    The naphtho-gamma-pyrone glycosides (3, 4, and 6) were found to have significant hepato-protective effects against galactosamine damage, which were higher than that of silybin from Silybum marianum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4728 mL 12.364 mL 24.728 mL 49.456 mL 61.82 mL
    5 mM 0.4946 mL 2.4728 mL 4.9456 mL 9.8912 mL 12.364 mL
    10 mM 0.2473 mL 1.2364 mL 2.4728 mL 4.9456 mL 6.182 mL
    50 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9891 mL 1.2364 mL
    100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-O-甲基芦荟新甙A; 7-O-Methylaloeresin A CFN90716 329361-25-3 C29H30O11 = 554.54 10mg QQ客服:1413575084
    芦荟新甙D; Aloeresin D CFN90717 105317-67-7 C29H32O11 = 556.56 10mg QQ客服:2159513211
    决明子苷; Cassiaside CFN90826 123914-49-8 C20H20O9 = 404.4 5mg QQ客服:3257982914
    红镰霉素龙胆二糖苷; Rubrofusarin-6-O-beta-D-gentiobioside CFN90827 24577-90-0 C27H32O15 = 596.5 10mg QQ客服:2932563308
    决明子苷B2; Cassiaside B2 CFN91134 218155-40-9 C39H52O25 = 920.8 5mg QQ客服:3257982914
    异红镰霉素龙胆二糖苷; Isorubrofusarin 10-gentiobioside CFN95119 200127-93-1 C27H32O15 = 596.5 10mg QQ客服:2932563308
    决明子苷C; Cassiaside C CFN95120 119170-52-4 C27H32O15 = 596.5 10mg QQ客服:2159513211
    决明子苷B; Cassiaside B CFN91123 119170-51-3 C26H30O14 = 566.5 5mg QQ客服:1148253675
    沉香四醇; Agarotetrol CFN90875 69809-22-9 C17H18O6 = 318.3 20mg QQ客服:2159513211
    4'-甲氧基沉香四醇; 4'-Methoxyagarotetrol CFN91077 123278-01-3 C18H20O7 = 348.35 5mg QQ客服:3257982914

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