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    6-乙酰基-2,2-二甲基色满酮

    6-Acetyl-2,2-dimethylchroman-4-one

    6-乙酰基-2,2-二甲基色满酮
    产品编号 CFN97171
    CAS编号 68799-41-7
    分子式 = 分子量 C13H14O3 = 218.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Vernonia cinerea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-乙酰基-2,2-二甲基色满酮 CFN97171 68799-41-7 1mg QQ客服:215959384
    6-乙酰基-2,2-二甲基色满酮 CFN97171 68799-41-7 5mg QQ客服:215959384
    6-乙酰基-2,2-二甲基色满酮 CFN97171 68799-41-7 10mg QQ客服:215959384
    6-乙酰基-2,2-二甲基色满酮 CFN97171 68799-41-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Universidad Veracuzana (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • PLoS One.2015, 10(5):e0127060
  • Auburn University2015, 1-58
  • SBRAS2016, 12
  • Food Chem.2016, 191:81-90
  • Molecules.2016, 21(10)
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • The Korea Journal of Herbology2016, 29-35
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Nutrients.2018, 10(7)
  • Molecules.2018, 23(3):E615
  • Biomed Pharmacother.2019, 111:262-269
  • Food and Agriculture Org. Of the UN2019, 151-160
  • BMC Complement Altern Med.2019, 19(1):325
  • Int J Mol Sci.2019, 20(23):E6071
  • Int J Mol Sci.2019, 20(8):E1855
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(20):3755
  • Molecules.2019, 24(22):E4022
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • J Mol Histol.2019, 50(4):343-354
  • Biomed Chromatogr.2019, 8:e4774
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • ...
  • 生物活性
    Description: 6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
    Targets: PAFR
    In vitro:
    Phytochemistry. 2000 Apr;53(8):833-6.
    Anti-platelet aggregation constituents from Gynura elliptica.[Pubmed: 10820787]

    METHODS AND RESULTS:
    A p-hydroxyacetophenone-like derivative, (+)-gynunone, and a chromane, together with six known compounds were isolated from the CHCl3 fraction of the roots of Gynura elliptica. Their structures were determined by means of spectral analyses.
    CONCLUSIONS:
    Among the isolates, 6-Acetyl-2,2-dimethylchroman-4-one and vanillin showed anti-platelet aggregation activity induced by arachidonic acid in vitro.
    Chem Biodivers. 2007 Dec;4(12):2835-44.
    Studies on the cytotoxicity of miscellaneous compounds from Eupatorium betonicaeforme (D.C.) Baker (Asteraceae).[Pubmed: 18081094 ]

    METHODS AND RESULTS:
    A detailed study on the cytotoxic effects of five known constituents isolated from the flowers and roots of Eupatorium betonicaeforme is reported, including 2,2-dimethyl-6-vinylchroman-4-one (1), 2-senecioyl-4-vinylphenol (2), 6-Acetyl-2,2-dimethylchroman-4-one (3), (4E)-8beta-angeloyloxy-9beta,10beta-dihydroxy-1-oxogermacra-4,11(13)-dien-12,6alpha-olide (4), and 3beta-hydroxyicosan-1,5beta-olide (5). The sesquiterpene lactone 4 exhibited the highest cytotoxicity, with IC50 values ranging from 3.9 to 9.9 microM, showing some degree of cell selectivity. The antiproliferative activity of 4 was examined towards HL-60 cells, and found to diminish cell viability in a dose-dependent manner. Moreover, at all concentrations tested, there was a decrease in the number of cells capable of incorporating 5-bromo-2'-deoxyuridine (BrdU), indicating disruption of DNA synthesis. The morphological changes induced by 4 were compatible with apoptotic cell death.
    CONCLUSIONS:
    This work, thus, corroborates the anticancer potential of Eupatorium secondary metabolites.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5809 mL 22.9043 mL 45.8085 mL 91.617 mL 114.5213 mL
    5 mM 0.9162 mL 4.5809 mL 9.1617 mL 18.3234 mL 22.9043 mL
    10 mM 0.4581 mL 2.2904 mL 4.5809 mL 9.1617 mL 11.4521 mL
    50 mM 0.0916 mL 0.4581 mL 0.9162 mL 1.8323 mL 2.2904 mL
    100 mM 0.0458 mL 0.229 mL 0.4581 mL 0.9162 mL 1.1452 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-乙酰基-2,2-二甲基色满酮; 6-Acetyl-2,2-dimethylchroman-4-one CFN97171 68799-41-7 C13H14O3 = 218.3 5mg QQ客服:215959384
    2,3-二氢-2,5-二甲基-4H-1-苯并吡喃-4-酮 ; 2,5-Dimethylchroman-4-one CFN96894 69687-87-2 C11H12O2 = 176.21 5mg QQ客服:1148253675
    2,5-二甲基-7-羟基色酮; Altechromone A CFN89130 38412-47-4 C11H10O3 = 190.19 5mg QQ客服:215959384
    羟基甲基氧丙基苯并吡喃酮; Cassiachromone CFN98359 28955-30-8 C13H12O4 = 232.2 5mg QQ客服:215959384
    dl-Aloesol ; dl-Aloesol CFN96962 104871-04-7 C13H14O4 = 234.25 5mg QQ客服:1413575084
    7-O-甲基芦荟新甙A; 7-O-Methylaloeresin A CFN90716 329361-25-3 C29H30O11 = 554.54 10mg QQ客服:2932563308
    芦荟新甙D; Aloeresin D CFN90717 105317-67-7 C29H32O11 = 556.56 10mg QQ客服:215959384
    决明子苷; Cassiaside CFN90826 123914-49-8 C20H20O9 = 404.4 5mg QQ客服:215959384
    红镰霉素龙胆二糖苷; Rubrofusarin-6-O-beta-D-gentiobioside CFN90827 24577-90-0 C27H32O15 = 596.5 10mg QQ客服:1413575084
    决明子苷B2; Cassiaside B2 CFN91134 218155-40-9 C39H52O25 = 920.8 5mg QQ客服:2932563308

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