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    红镰霉素龙胆二糖苷

    Rubrofusarin-6-O-beta-D-gentiobioside

    红镰霉素龙胆二糖苷
    产品编号 CFN90827
    CAS编号 24577-90-0
    分子式 = 分子量 C27H32O15 = 596.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Cassia obtusifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 1mg QQ客服:2932563308
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 5mg QQ客服:2932563308
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 10mg QQ客服:2932563308
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Texas A&M University (USA)
  • Gyeongsang National University (Korea)
  • Monash University Malaysia (Malaysia)
  • Biotech R&D Institute (USA)
  • University of East Anglia (United Kingdom)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of the Basque Country (Spain)
  • Semmelweis Unicersity (Hungary)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Universiti Malaysia Pahang (Malaysia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Complutense University of Madrid (Spain)
  • Macau University of Science and Technology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • Molecules.2016, 21(6)
  • Acta Physiologiae Plantarum2016, 38:7
  • Int J Oncol.2016, 49(4):1497-504
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Biochem Pharmacol.2017, 130:10-20
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • J Ethnopharmacol.2017, 198:205-213
  • Front Plant Sci.2017, 8:723
  • Sci Rep. 2017, 8207(7)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • ACS Nano.2018, 12(4):3385-3396
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Mol Cells.2018, 41(8):771-780
  • J Sep Sci.2018, 41(9):1938-1946
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Sci Rep.2018, 8:15059
  • Drug Invention Today2019, 12(6):1303-1306
  • J Adv Res.2019, 17:85-94
  • Molecules.2019, 24(7):E1290
  • New Journal of Chemistry2019, 43:12538-12547
  • Metabolites.2019, 9(11):E271
  • Biomolecules.2020, 10(2):E184
  • ...
  • 生物活性
    Description: Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive agent for advanced glycation end products-related diabetic complications.
    Targets: TGF-β/Smad | NF-kB | ERK | MAPK
    In vitro:
    Eur J Pharmacol. 2010 Sep 1;641(1):7-14.
    Extract of Cassiae Semen and its major compound inhibit S100b-induced TGF-beta1 and fibronectin expression in mouse glomerular mesangial cells.[Pubmed: 20483351 ]
    Non-enzymatic glycation reactions between reducing sugar and free reactive amino groups of protein lead to the formation of advanced glycation end products, which increase under conditions of aging or diabetes. A previous study showed that extracts of Cassiae Semen (CS), the seed of Cassia tora, had inhibitory activity on advanced glycation end products formation in vitro.
    METHODS AND RESULTS:
    To examine the pharmacological effects of a butanol-soluble extract of CS under conditions of diabetic nephropathy, we evaluated the expression of transforming growth factor-beta1 (TGF-beta1) and fibronectin, key mediators of diabetic nephropathy, in mouse glomerular mesangial cells cultured in the presence of S100b (a specific ligand for receptor of advanced glycation end products). CS inhibited S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK), and oxidative stress. Moreover, CS suppressed nuclear factor-kappa B (NF-kappaB) activation in S100b-stimulated mouse mesangial cells. To identify the active compounds of CS, three major compounds, rubrofusarin-6-O-beta-d-gentiobioside (CS-A), toralactone-9-O-beta-d-gentiobioside (CS-B), and cassiaside (CS-C), were tested in cells. Of these compounds, CS-A significantly decreased the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity.
    CONCLUSIONS:
    These findings suggest that CS, especially CS-A, has potential as a preventive agent for advanced glycation end products-related diabetic complications.
    Arch Pharm Res. 2006 Jul;29(7):587-90.
    Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation.[Pubmed: 16903080]

    METHODS AND RESULTS:
    Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-beta-D-gentiobioside (2), and toralactone-9-O-beta-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation.
    CONCLUSIONS:
    The structures of 1-3 were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-3) were evaluated for the inhibitory activity on AGEs formation in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3822 mL 16.7645 mL 33.5289 mL 41.9111 mL
    5 mM 0.3353 mL 1.6764 mL 3.3529 mL 6.7058 mL 8.3822 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3529 mL 4.1911 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6706 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    沉香四醇; Agarotetrol CFN90875 69809-22-9 C17H18O6 = 318.3 20mg QQ客服:1148253675
    4'-甲氧基沉香四醇; 4'-Methoxyagarotetrol CFN91077 123278-01-3 C18H20O7 = 348.35 5mg QQ客服:1148253675
    异沉香四醇; Isoagarotetrol CFN91076 104060-61-9 C17H18O6 = 318.32 5mg QQ客服:1413575084
    6-羟基-2-(2-苯乙基)色酮; 6-Hydroxy-2-(2-phenylethyl)chromone CFN91098 84294-90-6 C17H14O3 = 266.29 5mg QQ客服:2932563308
    6,7-二甲氧基-2-(苯基乙基)色酮; 6,7-Dimethoxy-2-phenethylchromone CFN91097 84294-87-1 C19H18O4 = 310.34 5mg QQ客服:2159513211
    Undulatoside A; Undulatoside A CFN96467 58108-99-9 C16H18O9 = 354.31 5mg QQ客服:1148253675
    Drynachromoside A; Drynachromoside A CFN92909 1507388-29-5 C22H28O13 = 500.45 5mg QQ客服:2932563308
    Cypellocarpin C; Cypellocarpin C CFN89273 294856-66-9 C26H32O11 = 520.53 5mg QQ客服:2159513211
    Eucamalduside A; Eucamalduside A CFN89020 1287220-29-4 C26H32O11 = 520.53 5mg QQ客服:2159513211
    Monnieriside A; Monnieriside A CFN92910 1401807-73-5 C16H18O10 = 370.31 5mg QQ客服:215959384

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