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  • 红镰霉素龙胆二糖苷

    Rubrofusarin-6-O-beta-D-gentiobioside

    红镰霉素龙胆二糖苷
    产品编号 CFN90827
    CAS编号 24577-90-0
    分子式 = 分子量 C27H32O15 = 596.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Cassia obtusifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 1mg QQ客服:215959384
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 5mg QQ客服:215959384
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 10mg QQ客服:215959384
    红镰霉素龙胆二糖苷 CFN90827 24577-90-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Washington State University (USA)
  • Donald Danforth Plant Science Center (USA)
  • Copenhagen University (Denmark)
  • Universitas islam negeri Jakarta (Indonesia)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Oslo (Norway)
  • MTT Agrifood Research Finland (Finland)
  • Universidad de La Salle (Mexico)
  • Texas A&M University (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Queensland (Australia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • National Cancer Center Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Tumour Biol.2015, 36(9):7027-34
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Ethnopharmacol.2017, 198:205-213
  • J Ethnopharmacol.2017, 206:327-336
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Front Pharmacol.2017, 8:205
  • Front Pharmacol.2017, 8:673
  • Front Plant Sci.2017, 8:723
  • Industrial Crops and Products2017, 95:286-295
  • Food Chem.2018, 252:207-214
  • Exp Neurobiol.2018, 27(3):200-209
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • J Med Food.2019, 22(10):1067-1077
  • Molecules.2019, 24(11):E2102
  • Chem Biol Interact.2019, 315:108910
  • Phytomedicine.2019, 59:152785
  • Comput Biol Chem.2019, 83:107096
  • J Mol Recognit.2020, 33(2):e2819
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive agent for advanced glycation end products-related diabetic complications.
    Targets: TGF-β/Smad | NF-kB | ERK | MAPK
    In vitro:
    Eur J Pharmacol. 2010 Sep 1;641(1):7-14.
    Extract of Cassiae Semen and its major compound inhibit S100b-induced TGF-beta1 and fibronectin expression in mouse glomerular mesangial cells.[Pubmed: 20483351 ]
    Non-enzymatic glycation reactions between reducing sugar and free reactive amino groups of protein lead to the formation of advanced glycation end products, which increase under conditions of aging or diabetes. A previous study showed that extracts of Cassiae Semen (CS), the seed of Cassia tora, had inhibitory activity on advanced glycation end products formation in vitro.
    METHODS AND RESULTS:
    To examine the pharmacological effects of a butanol-soluble extract of CS under conditions of diabetic nephropathy, we evaluated the expression of transforming growth factor-beta1 (TGF-beta1) and fibronectin, key mediators of diabetic nephropathy, in mouse glomerular mesangial cells cultured in the presence of S100b (a specific ligand for receptor of advanced glycation end products). CS inhibited S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK), and oxidative stress. Moreover, CS suppressed nuclear factor-kappa B (NF-kappaB) activation in S100b-stimulated mouse mesangial cells. To identify the active compounds of CS, three major compounds, rubrofusarin-6-O-beta-d-gentiobioside (CS-A), toralactone-9-O-beta-d-gentiobioside (CS-B), and cassiaside (CS-C), were tested in cells. Of these compounds, CS-A significantly decreased the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity.
    CONCLUSIONS:
    These findings suggest that CS, especially CS-A, has potential as a preventive agent for advanced glycation end products-related diabetic complications.
    Arch Pharm Res. 2006 Jul;29(7):587-90.
    Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation.[Pubmed: 16903080]

    METHODS AND RESULTS:
    Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-beta-D-gentiobioside (2), and toralactone-9-O-beta-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation.
    CONCLUSIONS:
    The structures of 1-3 were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-3) were evaluated for the inhibitory activity on AGEs formation in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3822 mL 16.7645 mL 33.5289 mL 41.9111 mL
    5 mM 0.3353 mL 1.6764 mL 3.3529 mL 6.7058 mL 8.3822 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3529 mL 4.1911 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6706 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二羟基-2-(1-甲基乙基)-4H-1-苯并吡喃-4-酮; 5,7-Dihydroxy-2-isopropylchromone CFN97544 96552-59-9 C12H12O4 = 220.2 5mg QQ客服:3257982914
    8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone; 8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone CFN89218 188818-27-1 C19H24O9 = 396.39 5mg QQ客服:2932563308
    6-乙酰基-2,2-二甲基色满酮; 6-Acetyl-2,2-dimethylchroman-4-one CFN97171 68799-41-7 C13H14O3 = 218.3 5mg QQ客服:215959384
    2,3-二氢-2,5-二甲基-4H-1-苯并吡喃-4-酮 ; 2,5-Dimethylchroman-4-one CFN96894 69687-87-2 C11H12O2 = 176.21 5mg QQ客服:1148253675
    2,5-二甲基-7-羟基色酮; Altechromone A CFN89130 38412-47-4 C11H10O3 = 190.19 5mg QQ客服:2159513211
    羟基甲基氧丙基苯并吡喃酮; Cassiachromone CFN98359 28955-30-8 C13H12O4 = 232.2 5mg QQ客服:2932563308
    dl-Aloesol ; dl-Aloesol CFN96962 104871-04-7 C13H14O4 = 234.25 5mg QQ客服:215959384
    7-O-甲基芦荟新甙A; 7-O-Methylaloeresin A CFN90716 329361-25-3 C29H30O11 = 554.54 10mg QQ客服:215959384
    芦荟新甙D; Aloeresin D CFN90717 105317-67-7 C29H32O11 = 556.56 10mg QQ客服:215959384
    决明子苷; Cassiaside CFN90826 123914-49-8 C20H20O9 = 404.4 5mg QQ客服:3257982914

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