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    异红镰霉素龙胆二糖苷

    Isorubrofusarin 10-gentiobioside

    异红镰霉素龙胆二糖苷
    产品编号 CFN95119
    CAS编号 200127-93-1
    分子式 = 分子量 C27H32O15 = 596.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Cassia obtusifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异红镰霉素龙胆二糖苷 CFN95119 200127-93-1 1mg QQ客服:1148253675
    异红镰霉素龙胆二糖苷 CFN95119 200127-93-1 5mg QQ客服:1148253675
    异红镰霉素龙胆二糖苷 CFN95119 200127-93-1 10mg QQ客服:1148253675
    异红镰霉素龙胆二糖苷 CFN95119 200127-93-1 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Mol Cells.2015, 38(9):765-72
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • HortTechnology2016, 26(6):816-819
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Free Radic Biol Med.2017, 112:191-199
  • Nat Prod Commun.2017, 12(5):771-778
  • Int J Anal Chem.2017, 2017:1254721
  • Molecules.2017, 22(12)
  • Phytomedicine.2017, 24:77-86
  • Front Plant Sci.2017, 8:723
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Lab Chip.2018, 18(6):971-978
  • J Nat Prod.2018, 81(4):966-975
  • Cancer Manag Res.2019, 11:483-500
  • J of Physics Conference Series2019, 1349(1)
  • Postharvest Biol Tec2019, 149:18-26
  • Journal of Apiculture2019, 34(2):131-136
  • Environ Toxicol.2019, 34(4):513-520.
  • Korean J of Crop Science2019, 452-458
  • Process Biochemistry2019, 85:106-115
  • Metabolites.2019, 9(11):E271
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
    Targets: AChR | BACE
    In vitro:
    Molecules. 2017 Dec 28;23(1). pii: E69.
    Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia.[Pubmed: 29283428]
    Cassia obtusifolia Linn. have been used to improve vision, inflammatory diseases, and as hepatoprotective agents and to promote urination from ancient times.
    METHODS AND RESULTS:
    In the present study, we investigated the influence of glycosylation of components of C. obtusifolia and structure-activity relationships (SARs) with respect to the inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), which are related to Alzheimer's disease (AD). All six C. obtusifolia-derived compounds, rubrofusarin (1), rubrofusarin 6-O-β-d-glucopyranoside (2), rubrofusarin 6-O-β-d-gentiobioside (3), nor-rubrofusarin 6-O-β-d-glucoside (4), isorubrofusarin 10-O-β-d-gentiobioside ( Isorubrofusarin 10-gentiobioside, 5), and rubrofusarin 6-O-β-d-triglucoside (6) showed promising inhibitory activity against AChE/BACE1. Compounds 3 and 4 showed most significant inhibition against AChE and BACE1, respectively. The SARs results emphasized the importance of gentiobiosyl moiety in the rubrofusarin for AChE inhibition, whereas the presence of hydroxyl group at C-8 and the glucosyl moiety at the C-6 position in the nor-rubrofusarin appeared to largely determine BACE1 inhibition. Kinetics and docking studies showed the lowest binding energy and highest affinity for mixed-type inhibitors, 3 and 4. Hydrophobic bonds interactions and the number of hydrogen bonds determined the strength of the protein-inhibitor interaction.
    CONCLUSIONS:
    These results suggest that C. obtusifolia and its constituents have therapeutic potential, and that the SARs of its active components are further explored with a view towards developing a treatment for AD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3822 mL 16.7645 mL 33.5289 mL 41.9111 mL
    5 mM 0.3353 mL 1.6764 mL 3.3529 mL 6.7058 mL 8.3822 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3529 mL 4.1911 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6706 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异红镰霉素龙胆二糖苷; Isorubrofusarin 10-gentiobioside CFN95119 200127-93-1 C27H32O15 = 596.5 10mg QQ客服:215959384
    决明子苷C; Cassiaside C CFN95120 119170-52-4 C27H32O15 = 596.5 10mg QQ客服:2159513211
    决明子苷B; Cassiaside B CFN91123 119170-51-3 C26H30O14 = 566.5 5mg QQ客服:1413575084
    沉香四醇; Agarotetrol CFN90875 69809-22-9 C17H18O6 = 318.3 20mg QQ客服:2932563308
    4'-甲氧基沉香四醇; 4'-Methoxyagarotetrol CFN91077 123278-01-3 C18H20O7 = 348.35 5mg QQ客服:3257982914
    异沉香四醇; Isoagarotetrol CFN91076 104060-61-9 C17H18O6 = 318.32 5mg QQ客服:2159513211
    6-羟基-2-(2-苯乙基)色酮; 6-Hydroxy-2-(2-phenylethyl)chromone CFN91098 84294-90-6 C17H14O3 = 266.29 5mg QQ客服:1413575084
    6,7-二甲氧基-2-(苯基乙基)色酮; 6,7-Dimethoxy-2-phenethylchromone CFN91097 84294-87-1 C19H18O4 = 310.34 5mg QQ客服:2159513211
    Undulatoside A; Undulatoside A CFN96467 58108-99-9 C16H18O9 = 354.31 5mg QQ客服:1413575084
    Drynachromoside A; Drynachromoside A CFN92909 1507388-29-5 C22H28O13 = 500.45 5mg QQ客服:1413575084

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