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  • 决明子苷B2

    Cassiaside B2

    决明子苷B2
    产品编号 CFN91134
    CAS编号 218155-40-9
    分子式 = 分子量 C39H52O25 = 920.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Cassia obtusifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    决明子苷B2 CFN91134 218155-40-9 1mg QQ客服:1148253675
    决明子苷B2 CFN91134 218155-40-9 5mg QQ客服:1148253675
    决明子苷B2 CFN91134 218155-40-9 10mg QQ客服:1148253675
    决明子苷B2 CFN91134 218155-40-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chungnam National University (Korea)
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  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Phytother Res.2015, 29(7):1088-96
  • Int J Mol Med.2015, 35(5):1237-45
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Chem Biol Interact.2016, 258:59-68
  • Sci Rep. 2017, 12953(7)
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Molecules.2017, 22(6)
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Biol Pharm Bull.2017, 40(6):797-806
  • ACS Nano.2018, 12(4):3385-3396
  • Lab Chip.2018, 18(6):971-978
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Planta Med.2018, 84(6-07):465-474
  • Front Pharmacol.2019, 10:1025
  • Food Res Int.2019, 123:125-134
  • Molecules.2019, 24(9):E1719
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Sci Rep.2019, 9(1):4646
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    ACS Omega. 2019 Jul 3;4(7):11621-11630.
    Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study.[Pubmed: 31460269]
    A number of nature-derived biologically active compounds comprise glycosides. In some cases, the glycosidic residue is needed for bioactivity; however, in other cases, glycosylation just improves some pharmacokinetic/dynamic parameters. The patterns of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibition by rubrofusarin 6-O-β-d-glucopyranoside (1), rubrofusarin 6-O-β-d-gentiobioside (2), rubrofusarin triglucoside (3), and cassiaside B2 (4) were compared with the aglycone, rubrofusarin, isolated from Cassia obtusifolia seeds.
    METHODS AND RESULTS:
    Rubrofusarin showed potent inhibition against the PTP1B enzyme (IC50; 16.95 ± 0.49 μM), and its glycosides reduced activity (IC50; 87.36 ± 1.08 μM for 1 and >100 μM for 2-4) than did the reference drug, ursolic acid (IC50; 2.29 ± 0.04 μM). Similarly, in hMAO-A inhibition, rubrofusarin displayed the most potent activity with an IC50 value of 5.90 ± 0.99 μM, which was twice better than the reference drug, deprenyl HCl (IC50; 10.23 ± 0.82 μM). An enzyme kinetic and molecular docking study revealed rubrofusarin to be a mixed-competitive inhibitor of both these enzymes. In a western blot analysis, rubrofusarin increased glucose uptake significantly and decreased the PTP1B expression in a dose-dependent manner in insulin-resistant HepG2 cells, increased the expression of phosphorylated protein kinase B (p-Akt) and phosphorylated insulin receptor substrate-1 (p-IRS1) (Tyr 895), and decreased the expression of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK), key enzymes of gluconeogenesis.
    CONCLUSIONS:
    Our overall results show that glycosylation retards activity; however, it reduces toxicity. Thus, Cassia seed as functional food and rubrofusarin as a base can be used for the development of therapeutic agents against comorbid diabetes and depression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.086 mL 5.4301 mL 10.8601 mL 21.7202 mL 27.1503 mL
    5 mM 0.2172 mL 1.086 mL 2.172 mL 4.344 mL 5.4301 mL
    10 mM 0.1086 mL 0.543 mL 1.086 mL 2.172 mL 2.715 mL
    50 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.4344 mL 0.543 mL
    100 mM 0.0109 mL 0.0543 mL 0.1086 mL 0.2172 mL 0.2715 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Undulatoside A; Undulatoside A CFN96467 58108-99-9 C16H18O9 = 354.31 5mg QQ客服:1148253675
    Drynachromoside A; Drynachromoside A CFN92909 1507388-29-5 C22H28O13 = 500.45 5mg QQ客服:2159513211
    Cypellocarpin C; Cypellocarpin C CFN89273 294856-66-9 C26H32O11 = 520.53 5mg QQ客服:3257982914
    Eucamalduside A; Eucamalduside A CFN89020 1287220-29-4 C26H32O11 = 520.53 5mg QQ客服:2932563308
    Monnieriside A; Monnieriside A CFN92910 1401807-73-5 C16H18O10 = 370.31 5mg QQ客服:3257982914
    Cnidimol A ; Cnidimol A CFN96860 103629-80-7 C15H16O5 = 276.28 5mg QQ客服:3257982914
    番樱桃素; Eugenin CFN90808 480-34-2 C11H10O4 = 206.2 10mg QQ客服:1148253675
    8-Methyleugenitol; 8-Methyleugenitol CFN96198 41682-21-7 C12H12O4 = 220.2 5mg QQ客服:215959384
    5,7-二羟基-2-(1-甲基乙基)-4H-1-苯并吡喃-4-酮; 5,7-Dihydroxy-2-isopropylchromone CFN97544 96552-59-9 C12H12O4 = 220.2 5mg QQ客服:3257982914
    8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone; 8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone CFN89218 188818-27-1 C19H24O9 = 396.39 5mg QQ客服:2159513211

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