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  • 3'-羟基葛根素芹菜糖苷

    3'-Hydroxymirificin

    3'-羟基葛根素芹菜糖苷
    产品编号 CFN95102
    CAS编号 168035-02-7
    分子式 = 分子量 C26H28O14 = 564.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3'-羟基葛根素芹菜糖苷 CFN95102 168035-02-7 1mg QQ客服:2932563308
    3'-羟基葛根素芹菜糖苷 CFN95102 168035-02-7 5mg QQ客服:2932563308
    3'-羟基葛根素芹菜糖苷 CFN95102 168035-02-7 10mg QQ客服:2932563308
    3'-羟基葛根素芹菜糖苷 CFN95102 168035-02-7 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kamphaengphet Rajabhat University (Thailand)
  • University of East Anglia (United Kingdom)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Cincinnati (USA)
  • University of Auckland (New Zealand)
  • Yale University (USA)
  • Semmelweis Unicersity (Hungary)
  • Universidade do Porto (Portugal)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Illinois (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • Regional Crop Research Institute (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • New Zealand J. Forestry Sci.2014, 44:17
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Chromatogr Sci.2015, 53(5):824-9
  • Acta Biochim Pol.2015, 62(2):253-8
  • Ind Crops Prod.2015, 67:185-191
  • University of Limpopo2016, 1777
  • Food Chem.2016, 191:81-90
  • Nat Prod Sci.2016, 22(2)
  • Phytomedicine.2016, 23(4):331-9
  • J Ethnopharmacol.2017, 198:87-90
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Plant Cell Physiol.2018, 59(1):128-141
  • Sci Rep.2018, 8:15059
  • J Nat Prod.2018, 81(4):966-975
  • Front Aging Neurosci.2019, 11:230
  • Microb Pathog.2019, 131:128-134
  • Molecules.2019, 24(2):E343
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • TCI CO.2019, US20190151257A1
  • J Pharmaceut Biomed2020, 182:113110
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(16):3206-3212.
    Absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro.[Pubmed: 29171242 ]
    Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1∶1∶1. The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper.
    METHODS AND RESULTS:
    The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-β-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranoside, genistein-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (ambocin), 3'-hydroxymirificin, 6″-O-β-D-xylosylpuerarin, biochanin A-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-β-D-glucopyranoside, daidzein-7-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside, and daidzein-7-O-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside. By using human Caco-2 monolayer as an intestinal epithelial cell model in vitro, the permeability of above-mentioned 25 isoflavonoids in TMF were studied from the apical (AP) side to basolateral (BL) side or from the BL side to AP side. The assay compounds were determined by reversed phased high-performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and and compared with those of propranolol and atenolol, which are the transcellular transport marker and as a control substance for high and poor permeability, respectively. The Papp values of daidzein and formononetin were (2.55±0.03) ×10⁻⁵,(3.06±0.01) ×10⁻⁵ cm•s⁻¹ from AP side to BL side, respectively, and (2.62±0.00) ×10⁻⁵, (2.65±0.11) ×10⁻⁵ cm•s⁻¹ from BL side to AP side, respectively. Under the condition of this experiment, the Papp value was (2.66±0.32) ×10⁻⁵ cm•s⁻¹ for propranolol and (2.34±0.10) ×10⁻⁷ cm•s⁻¹ for atenolol. The Papp values of daidzein and formononetin were at a same magnitude with those of propranolol. And the Papp values of other 23 isoflavonoid compounds were at a same magnitude with those of atenolol. On the other hand, the rats of Papp AP→BL/Papp BL→AP of daidzein and formononetin on the influx transport were 0.97 and 1.15, respectively.
    CONCLUSIONS:
    It can be predicted that daidzein and formononetin can be absorbed across intestinal epithelial cells to go to the body circulation by the passive diffusion mechanism and they were assigned to the well-absorbed compounds. Other 23 isoflavonoid compounds were assigned to the poorly absorbed compounds. Because of the rats of Papp AP→BL/Papp BL→AP of 5-hydroxylononin, genistin, lanceolarin, kakkanin, and genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside were 0.18, 0.28, 0.45, 0.38, 0.49, they may have been involved in the efflux mechanism in Caco-2 cells monolayer model from the BL side to AP side direction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7715 mL 8.8574 mL 17.7148 mL 35.4296 mL 44.287 mL
    5 mM 0.3543 mL 1.7715 mL 3.543 mL 7.0859 mL 8.8574 mL
    10 mM 0.1771 mL 0.8857 mL 1.7715 mL 3.543 mL 4.4287 mL
    50 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.7086 mL 0.8857 mL
    100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.3543 mL 0.4429 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:1148253675
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:3257982914
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:1148253675
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:2159513211
    3'-羟基葛根素; 3'-Hydroxy Puerarin CFN90236 117076-54-5 C21H20O10 = 432.38 20mg QQ客服:215959384
    3'-甲氧基葛根素; 3'-Methoxypuerarin CFN90780 117047-07-1 C22H22O10 = 446.4 20mg QQ客服:2159513211
    大豆苷; Daidzin CFN99101 552-66-9 C21H20O9 = 416.38 20mg QQ客服:1148253675
    大豆苷元-7-O-葡萄糖醛酸苷; Daidzein 7-O-glucuronide CFN70352 38482-80-3 C21H18O10 = 430.4 5mg QQ客服:3257982914
    二氢大豆苷; Dihydrodaidzin CFN90755 121927-96-6 C21H22O9 = 418.4 5mg QQ客服:1148253675
    4''-甲氧基大豆苷; 4''-methyloxy-Daidzin CFN93005 1195968-02-5 C22H22O9 = 430.40 5mg QQ客服:3257982914

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