Info: Read More
  • 中药标准品生产商,产品定制服务
  • 印枳碱


    产品编号 CFN91133
    CAS编号 456-12-2
    分子式 = 分子量 C18H19NO3 = 297.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Cannabis sativa L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    印枳碱 CFN91133 456-12-2 10mg QQ客服:215959384
    印枳碱 CFN91133 456-12-2 20mg QQ客服:215959384
    印枳碱 CFN91133 456-12-2 50mg QQ客服:215959384
    印枳碱 CFN91133 456-12-2 100mg QQ客服:215959384
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: 或

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universidad de La Salle (Mexico)
  • Wageningen University (Netherlands)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Yale University (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • Texas A&M University (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • MTT Agrifood Research Finland (Finland)
  • Colorado State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharm Biomed Anal.2022, 207:114398.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • J Nat Med.2017, 71(2):457-462
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Molecules.2020, 25(18),4089.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • J Cell Physiol.2021, 236(3):1950-1966.
  • J Pharmaceut Biomed2020, 182:113110
  • Molecules.2022, 27(7):2093.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Appl. Sci.2020, 10(20),7374.
  • Phytomedicine.2019, 55:229-237
  • Mol Microbiol.2019, 112(1):317-332
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • J Ethnopharmacol.2019, 241:112025
  • J Mass Spectrom.2022, 57(2):e4810.
  • Antibiotics.2022, 11(4), 510.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Molecules.2019, 24(6):E1177
  • Plant Pathology2022, 13527
  • ...
  • 生物活性
    Description: Aegeline has anti-diabetic and anti-dyslipidemic activities, it inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells, it also inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance. Aegeline mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
    Targets: PPARγ | C/EBPα | FAS | hMSCs
    In vitro:
    Bioorg Med Chem Lett. 2019 Feb 1;29(3):454-460.
    Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.[Pubmed: 30579794 ]
    Herein, we have identified yeast Sec22p (ySec22p), a SNARE protein essential for endoplasmic reticulum to Golgi trafficking, as a suppressor of Bax-induced yeast apoptosis and corroborated published observations that ySec22p suppresses α-synuclein's toxicity in yeast. It has been suggested that compounds which enhance expression, in neurons, of human homologues of ySec22p (Sec22Bp/Sec22p/Sec22A) would prevent synucleinopathies, such as Parkinson's disease.
    With the aim of finding a small molecule that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened using yeast cells that express either human α-synuclein or human Bax. The antioxidant aegeline, an alkaloid-amide occurring in the leaves of the plant Aegle marmelos Correa, was the only molecule that overcame apoptosis induced by both α-synuclein and Bax in yeast. Besides, aegeline also prevented growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells.
    These results highlight the importance of yeast systems to identify rapidly molecules that may prevent the onset of apoptosis that occurs in Parkinson's disease.
    Eur J Med Chem. 2018 Jan 1;143:780-791.
    Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells.[Pubmed: 29220798 ]
    Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our group had reported natural product Aegeline (amino-alcohol) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound.
    With this background, we synthesized a series of novel amino alcohol and thiazolidinedione hybrid molecules and studied their antiadipogenic activity. As a result, we have identified a potent hybrid compound 12c as an inhibitor of adipocyte differentiation. The compound 12c inhibits lipid accumulation and adipogenesis in 3T3-L1 preadipocyte cell line. Exposure of compound 12c blocks mitotic clonal expansion and arrests cells in S-phase of cell cycle. Detailed analysis showed that compound 12c decreases expression of two major transcription factors that are involved in adipocyte differentiation, PPARγ, C/EBPα, and other adipogenesis associated genes like aP2 and FAS.
    Thus, we concluded that compound 12c shows potential ability to inhibit adipocyte differentiation which can be used therapeutically for the treatment of obesity and its associated metabolic disorders.
    In vivo:
    Metabolism. 2018 Aug;85:1-13.
    Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance.[Pubmed: 29524448 ]
    In our drug discovery program of natural product, earlier we have reported Aegeline that is N-acylated-1-amino-2- alcohol, which was isolated from the leaves of Aeglemarmelos showed anti-hyperlipidemic activity for which the QSAR studies predicted the compound to be the β3-AR agonist, but the mechanism of its action was not elucidated. In our present study, we have evaluated the β3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline and its beneficial effect in insulin resistance. In this study, we have proposed the novel pharmacophore model using reported molecules for antihyperlipidemic activity. The reported pharmacophore features were also compared with the newly developed pharmacophore model for the observed biological activity.
    Based on 3D pharmacophore modeling of known β3AR agonist, we screened 20 synthetic derivatives of Aegeline from the literature. From these, the top scoring compound 10C was used for further studies. The in-slico result was further validated in HEK293T cells co-trransfected with human β3-AR and CRE-Luciferase reporter plasmid for β3-AR activity.The most active compound was selected and β3-AR activity was further validated in white and brown adipocytes differentiated from human mesenchymal stem cells (hMSCs). Insulin resistance model developed in hMSC derived adipocytes was used to study the insulin sensitizing property. 8 week HFD fed C57BL6 mice was given 50 mg/Kg of the selected compound and metabolic phenotyping was done to evaluate its anti-diabetic effect. As predicted by in-silico 3D pharmacophore modeling, the compound 10C was found to be the most active and specific β3-AR agonist with EC50 value of 447 nM. The compound 10C activated β3AR pathway, induced lipolysis, fatty acid oxidation and increased oxygen consumption rate (OCR) in human adipocytes. Compound 10C induced expression of brown adipocytes specific markers and reverted chronic insulin induced insulin resistance in white adipocytes. The compound 10C also improved insulin sensitivity and glucose tolerance in 8 week HFD fed C57BL6 mice.
    This study enlightens the use of in vitro insulin resistance model close to human physiology to elucidates the insulin sensitizing activity of the compound 10C and edifies the use of β3AR agonist as therapeutic interventions for insulin resistance and type 2 diabetes.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3625 mL 16.8124 mL 33.6247 mL 67.2495 mL 84.0619 mL
    5 mM 0.6725 mL 3.3625 mL 6.7249 mL 13.4499 mL 16.8124 mL
    10 mM 0.3362 mL 1.6812 mL 3.3625 mL 6.7249 mL 8.4062 mL
    50 mM 0.0672 mL 0.3362 mL 0.6725 mL 1.345 mL 1.6812 mL
    100 mM 0.0336 mL 0.1681 mL 0.3362 mL 0.6725 mL 0.8406 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    阿魏酸酰胺; Ferulamide CFN97041 61012-31-5 C10H11NO3 = 193.2 5mg QQ客服:1413575084
    印枳碱; Aegeline CFN91133 456-12-2 C18H19NO3 = 297.4 20mg QQ客服:1413575084
    N-咖啡酰O-甲基酪胺; N-Caffeoyl O-methyltyramine CFN70295 189307-47-9 C18H19NO4 = 313.4 5mg QQ客服:215959384
    N-反式咖啡酰真蛸胺; N-trans-caffeoyloctopamine CFN95264 1378868-10-0 C17H17NO5 = 315.3 5mg QQ客服:2932563308
    N-反式咖啡酰酪胺; N-trans-caffeoyltyramine CFN95265 103188-48-3 C17H17NO4 = 299.3 5mg QQ客服:215959384
    N-反式阿魏酰酪胺; N-trans-Feruloyltyramine CFN97135 66648-43-9 C18H19NO4 = 313.4 10mg QQ客服:1413575084
    N-反式-阿魏酰-3-甲氧基酪胺; N-trans-Feruloyl-3-methoxytyramine CFN97268 78510-19-7 C19H21NO5 = 343.4 5mg QQ客服:3257982914
    芥子酰酪胺; N-trans-Sinapoyltyramine CFN91137 200125-11-7 C19H21NO5 = 343.4 10mg QQ客服:3257982914
    4-羟基肉桂酰胺; 4-Hydroxycinnamamide CFN99895 194940-15-3 C9H9NO2 = 163.2 5mg QQ客服:2932563308
    N-对反式香豆酰酪胺; N-p-trans-Coumaroyltyramine CFN98494 36417-86-4 C17H17NO3 = 283.3 10mg QQ客服:1413575084





    在线QQ: 1413575084


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产