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  • 老鹳草素

    Geraniin

    老鹳草素
    产品编号 CFN90256
    CAS编号 60976-49-0
    分子式 = 分子量 C41H28O27 = 952.64
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Phyllanthus urinaria L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    老鹳草素 CFN90256 60976-49-0 10mg QQ客服:1148253675
    老鹳草素 CFN90256 60976-49-0 20mg QQ客服:1148253675
    老鹳草素 CFN90256 60976-49-0 50mg QQ客服:1148253675
    老鹳草素 CFN90256 60976-49-0 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Wroclaw Medical University (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Maryland (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • National Research Council of Canada (Canada)
  • Kitasato University (Japan)
  • Universitas Airlangga (Indonesia)
  • China Medical University (Taiwan)
  • Universidad de Buenos Aires (Argentina)
  • University of Parma (Italy)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Lund University (Sweden)
  • Tokyo Woman's Christian University (Japan)
  • Ateneo de Manila University (Philippines)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Oncology Letters2018, 4690-4696
  • Nat Prod Commun.2018, 10.1177
  • China Pharmacy2015, 26(27)
  • Journal of Food Composition and Analysis2021, 100:103905.
  • Antioxidants (Basel).2020, 9(6):466.
  • Antibiotics.2022, 11(4), 510.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Enzyme and Microbial Technology2022, 110002.
  • Front Pharmacol.2021, 12:690113.
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Comput Biol Chem.2019, 83:107096
  • Molecules.2021, 26(19):6032.
  • Lab Chip.2018, 18(6):971-978
  • Drug Des Devel Ther.2020, 14:969-976.
  • Front Cell Dev Biol.2020, 8:32.
  • Medicina (Kaunas).2020, 56(12):685.
  • Nutr Res Pract2019, 13:e45
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Food Funct.2021, 12(4):1469-1481.
  • Cell Rep.2020, 32(11):108158.
  • J Biol Chem.2021, 297(6):101362.
  • ...
  • 生物活性
    Description: Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death.
    Targets: NF-kB | ERK | Nrf2 | PI3K | Akt | NADPH-oxidase | HO-1 | ROS | MMP(e.g.TIMP) | p53 | NQO1 | TNF-α
    In vitro:
    Exp Cell Res. 2015 Jan 1;330(1):91-101.
    Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model.[Pubmed: 25016282]
    Wear particle-induced osteolysis and subsequent aseptic loosening remains the most common complication that limits the longevity of prostheses. Wear particle-induced osteoclastogenesis is known to be responsible for extensive bone erosion that leads to prosthesis failure. Thus, inhibition of osteoclastic bone resorption may serve as a therapeutic strategy for the treatment of wear particle induced osteolysis.
    METHODS AND RESULTS:
    In this study, we demonstrated for the first time that geraniin, an active natural compound derived from Geranium thunbergii, ameliorated particle-induced osteolysis in a Ti particle-induced mouse calvaria model in vivo. We also investigated the mechanism by which geraniin exerts inhibitory effects on osteoclasts. Geraniin inhibited RANKL-induced osteoclastogenesis in a dose-dependent manner, evidenced by reduced osteoclast formation and suppressed osteoclast specific gene expression. Specially, geraniin inhibited actin ring formation and bone resorption in vitro. Further molecular investigation demonstrated geraniin impaired osteoclast differentiation via the inhibition of the RANKL-induced NF-κB and ERK signaling pathways, as well as suppressed the expression of key osteoclast transcriptional factors NFATc1 and c-Fos.
    CONCLUSIONS:
    Collectively, our data suggested that geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo. Geraniin is therefore a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure.
    Can J Physiol Pharmacol. 2013 Dec;91(12):1016-24.
    Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo.[Pubmed: 24289071]
    Geraniin has previously been reported to possess extensive biological activity. In this study, we reported that geraniin is an inhibitor of tumor activity in vitro and in vivo.
    METHODS AND RESULTS:
    Geraniin suppressed the proliferation of A549 cells in a dose- and time-dependent manner. Geraniin arrested the cell cycle in the S phase and induced a significant accumulation of reactive oxygen species (ROS), as well as an increased percentage of cells with mitochondrial membrane potential (MMP) disruption. Western blot analysis showed that geraniin inhibited Bcl-2 expression and induced Bax expression to disintegrate the outer mitochondrial membrane and cause cytochrome c release. Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascades. Additionally, geraniin resulted in tumor growth inhibition in A549 xenografts.
    CONCLUSIONS:
    Our results indicate cytotoxic activity of geraniin towards cancer cells in vitro and in vivo.
    J Biochem Mol Toxicol . 2017 Sep;31(9).
    Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression[Pubmed: 28590547]
    Abstract This study investigated the anticancer effects of geraniin on ovarian cancer cells and the signaling pathways involved. Ovarian cancer cells were treated with different concentrations of geraniin for 48 h and examined for viability, apoptosis, mitochondrial membrane depolarization, and gene expression. Xenograft tumor studies were performed to determine the anticancer activity of geraniin in vivo. Geraniin significantly decreased cancer cell viability in a concentration-dependent fashion. Geraniin significantly triggered apoptosis, which was accompanied by loss of mitochondrial membrane potential and increased cytochrome c release and caspsase-3 activity. Mechanistically, geraniin significantly downregulated Mcl-1 and impaired NF-κB p65 binding to the mcl-1 promoter. Overexpression of Mcl-1 significantly reversed geraniin-induced apoptosis in OVCAR3 cells. In addition, geraniin retarded ovarian cancer growth and reduced expression of phospho-p65 and Mcl-1. Collectively, geraniin elicits growth suppression in ovarian cancer through inhibition of NF-κB and Mcl-1 and may provide therapeutic benefits for this malignancy. Keywords: NF-κB; growth suppression; ovarian cancer; phytochemical.
    In vivo:
    Bioorg Med Chem Lett. 2015 Feb 1;25(3):673-9.
    Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats.[Pubmed: 25532904]
    In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats.
    METHODS AND RESULTS:
    The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation.
    CONCLUSIONS:
    These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0497 mL 5.2486 mL 10.4971 mL 20.9943 mL 26.2429 mL
    5 mM 0.2099 mL 1.0497 mL 2.0994 mL 4.1989 mL 5.2486 mL
    10 mM 0.105 mL 0.5249 mL 1.0497 mL 2.0994 mL 2.6243 mL
    50 mM 0.021 mL 0.105 mL 0.2099 mL 0.4199 mL 0.5249 mL
    100 mM 0.0105 mL 0.0525 mL 0.105 mL 0.2099 mL 0.2624 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose; Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose CFN95462 1825287-22-6 C35H28O17 = 720.6 10mg QQ客服:1148253675
    Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-β-D-glucose; Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose CFN90881 205370-59-8 C42H32O21 = 872.7 20mg QQ客服:2932563308
    2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose; 2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose CFN95470 1781226-44-5 C28H24O17 = 632.5 5mg QQ客服:3257982914
    老鹳草素; Geraniin CFN90256 60976-49-0 C41H28O27 = 952.64 20mg QQ客服:215959384
    叶下珠鞣质C; Phyllanthusiin C CFN95260 142674-52-0 C40H30O26 = 926.7 5mg QQ客服:215959384
    诃子鞣酸; Chebulagic acid CFN92295 23094-71-5 C41H30O27 = 954.7 5mg QQ客服:215959384
    诃子林鞣酸; Chebulinic acid CFN92296 18942-26-2 C41H32O27 = 956.7 20mg QQ客服:2159513211
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:1413575084
    月见草素 B; Oenothein B CFN91651 104987-36-2 C68H48O44 = 1569.1 5mg QQ客服:2159513211
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖; 1,2,3,6-Tetragalloylglucose CFN00447 79886-50-3 C34H28O22 = 788.57 10mg QQ客服:215959384

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