Triptoquinone A
Triptoquinone A
|
|
产品编号 |
CFN96475 |
| CAS编号 |
142950-86-5 |
| 分子式 = 分子量 |
C20H24O4 = 328.40 |
| 产品纯度 |
>=98% |
| 物理属性 |
Orange powder |
| 化合物类型 |
Quinones |
| 植物来源 |
The roots of Tripterygium wilfordii Hook.f. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| Triptoquinone A |
CFN96475 |
142950-86-5 |
1mg |
QQ客服：1457312923 |
| Triptoquinone A |
CFN96475 |
142950-86-5 |
5mg |
QQ客服：1457312923 |
| Triptoquinone A |
CFN96475 |
142950-86-5 |
10mg |
QQ客服：1457312923 |
| Triptoquinone A |
CFN96475 |
142950-86-5 |
20mg |
QQ客服：1457312923 |
1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。
2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。
3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
订购流程
1. 在线订购
请联系我们QQ客服
2. 电话订购
请拨打电话：
027-84237683 或 027-84237783
3. 邮件或传真订购
发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680
提供订购信息
为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
1. 产品编号（CAS No.或产品名称）
2. 发货地址
3. 联系方法 (联系人，电话）
4. 开票抬头 (如果需要发票的客户）
5. 发票地址（发货地址与发票地址不同）
发货时间
1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。
2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。
3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Istanbul University (Turkey)
Donald Danforth Plant Science Center (USA)
Cornell University (USA)
Monash University Malaysia (Malaysia)
Anna University (India)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
University of Helsinki (Finland)
University of Stirling (United Kingdom)
Univerzita Karlova v Praze (Czech Republic)
University Medical Center Mainz (Germany)
VIT University (India)
Ateneo de Manila University (Philippines)
Texas A&M University (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synthase in vascular smooth muscle, thus inhibiting development of L-arginine-induced vasorelaxation. |
| Targets: |
NO | NOS | IL Receptor |
| In vitro: |
| Biochem Biophys Res Commun. 1996 Jul 16;224(2):579-85. | | Suppression of inducible nitric oxide synthase mRNA expression by tryptoquinone A.[Pubmed: 8702429 ] | Triptoquinone A (TQA), which is an anti-inflammatory constituent in plants, was studied for its suppressive effect on nitric oxide production by LPS.
METHODS AND RESULTS:
TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS. The suppression level of iNOS gene expression by TQA was comparable to that by dexamethasone.
CONCLUSIONS:
TQA may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. |
|
| In vivo: |
| Life Sci. 1996;59(3):PL49-54. | | Inhibition by triptoquinone-A of LPS- and IL-1 beta-primed induction of NO synthase in rat thoracic aorta.[Pubmed: 8699928] |
METHODS AND RESULTS:
We investigated the effect of Triptoquinone A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). Prophylactic application of TQA selectively prevented LPS-primed initiation of L-arginine (Arg)-induced relaxation, and cGMP formation of rat thoracic aorta, and LPS-stimulated nitrite production by cultured aortic smooth muscle cells, which appear to be mediated by NOS expressed by LPS in vascular smooth muscle. TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation.
CONCLUSIONS:
These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.0451 mL |
15.2253 mL |
30.4507 mL |
60.9013 mL |
76.1267 mL |
| 5 mM |
0.609 mL |
3.0451 mL |
6.0901 mL |
12.1803 mL |
15.2253 mL |
| 10 mM |
0.3045 mL |
1.5225 mL |
3.0451 mL |
6.0901 mL |
7.6127 mL |
| 50 mM |
0.0609 mL |
0.3045 mL |
0.609 mL |
1.218 mL |
1.5225 mL |
| 100 mM |
0.0305 mL |
0.1523 mL |
0.3045 mL |
0.609 mL |
0.7613 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
部分图片展示
联系方式
电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com
湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房
ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证
天然化合物与对照品的研发和生产。
