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  • Tetillapyrone

    Tetillapyrone

    Tetillapyrone
    产品编号 CFN95404
    CAS编号 363136-43-0
    分子式 = 分子量 C11H14O6 = 242.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 From Tetilla japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Tetillapyrone CFN95404 363136-43-0 1mg QQ客服:1413575084
    Tetillapyrone CFN95404 363136-43-0 5mg QQ客服:1413575084
    Tetillapyrone CFN95404 363136-43-0 10mg QQ客服:1413575084
    Tetillapyrone CFN95404 363136-43-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Harvard University (USA)
  • National Research Council of Canada (Canada)
  • National Cancer Center Research Institute (Japan)
  • Complutense University of Madrid (Spain)
  • Universidade Federal de Santa Catarina (Brazil)
  • Chulalongkorn University (Thailand)
  • University of Minnesota (USA)
  • Universit?t Basel (Switzerland)
  • University of Maryland School of Medicine (USA)
  • S.N.D.T. Women's University (India)
  • University of Eastern Finland (Finland)
  • Sri Ramachandra University (India)
  • Melbourne University (Australia)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(23):E4303
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Molecules.2020 ,25(16):3697.
  • Neurochem Int.2020, 133:104629
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • Journal of Molecular Liquids2021, 334:116014.
  • Sci Rep.2017, 7:46299
  • Chemistry of Plant Materials.2016, 33-46
  • PLoS One.2018, 13(4):e0195642
  • Phytomedicine.2023, 117:154929.
  • J Ethnopharmacol.2017, 198:91-97
  • Biomed Pharmacother.2021, 137:111362.
  • Food Science and Biotechnology2023, 2023:1007
  • Int J Mol Sci.2022, 23(20):12516.
  • Curr Res Virol Sci.2022, 3:100019.
  • Foods.2022, 12(1):136.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • Academic J of Second Military Medical University2019, 40(1)
  • Sci Rep.2019, 9(1):6429
  • Biomed Pharmacother.2020, 125:109784.
  • Sci Rep. 2017, 12953(7)
  • ...
  • 生物活性
    Description: Tetillapyrone is weakly cytotoxic
    In vitro:
    Mar Drugs . 2016 Apr 26;14(5):82.
    Cytotoxic Compounds from the Saudi Red Sea Sponge Xestospongia testudinaria[Pubmed: 27128926]
    Bioassay-guided fractionation of the organic extract of the Red Sea sponge Xestospongia testudinaria led to the isolation of 13 compounds including two new sterol esters, xestosterol palmitate (2) and xestosterol ester of l6'-bromo-(7'E,11'E,l5'E)-hexadeca-7',11',l5'-triene-5',13'-diynoic acid (4), together with eleven known compounds: xestosterol (1), xestosterol ester of 18'-bromooctadeca-7'E,9'E-diene-7',15'-diynoic acid (3), and the brominated acetylenic fatty acid derivatives, (5E,11E,15E,19E)-20-bromoeicosa-5,11,15,19-tetraene-9,17-diynoic acid (5), 18,18-dibromo-(9E)-octadeca-9,17-diene-5,7-diynoic acid (6), 18-bromooctadeca-(9E,17E)-diene-7,15-diynoic acid (7), 18-bromooctadeca-(9E,13E,17E)-triene-7,15-diynoic acid (8), l6-bromo (7E,11E,l5E)hexadeca-7,11,l5-triene-5,13-diynoic acid (9), 2-methylmaleimide-5-oxime (10), maleimide-5-oxime (11), tetillapyrone (12), and nortetillapyrone (13). The chemical structures of the isolated compounds were accomplished using one- and two-dimensional NMR, infrared and high-resolution electron impact mass spectroscopy (1D, 2D NMR, IR and HREIMS), and by comparison with the data of the known compounds. The total alcoholic and n-hexane extracts showed remarkable cytotoxic activity against human cervical cancer (HeLa), human hepatocellular carcinoma (HepG-2), and human medulloblastoma (Daoy) cancer cell lines. Interestingly, the dibrominated C18-acetylenic fatty acid (6) exhibited the most potent growth inhibitory activity against these cancer cell lines followed by Compounds 7 and 9. Apparently, the dibromination of the terminal olefinic moiety has an enhanced effect on the cytotoxic activity.
    Pharmacogn Mag . Apr-Jun 2016;12(46):114-119.
    Studies on the Red Sea Sponge Haliclona sp. for its Chemical and Cytotoxic Properties[Pubmed: 27076747]
    Background: A great number of novel compounds with rich chemical diversity and significant bioactivity have been reported from Red Sea sponges. Objective: To isolate, identify, and evaluate the cytotoxic activity of the chemical constituents of a sponge belonging to genus Haliclona collected from the Eastern coast of the Red Sea. Materials and methods: The total ethanolic extract of the titled sponge was subjected to intensive chromatographic fractionation and purification guided by cytotoxic bioassay toward various cancer cell lines. The structures of the isolated compounds were elucidated using spectroscopic techniques including one-dimension and two-dimension nuclear magnetic resonance, mass spectrometry, ultraviolet, and infrared data, as well as comparison with the reported spectral data for the known compounds. X-ray single-crystal structure determination was performed to determine the absolute configuration of compound 4. The screening of antiproliferative activity of the compounds was carried on three tumor cell lines, namely the human cervical cancer (HeLa), human hepatocellular carcinoma (HepG2), and human medulloblastoma (Daoy) cells using MTT assay. Results: This investigation resulted in the isolation of a new indole alkaloid, 1-(1H-indol-3-yloxy) propan-2-ol (1), with the previously synthesized pyrrolidine alkaloid, (2R, 3S, 4R, 5R) pyrrolidine-(1-hydroxyethyl)-3,4-diol hydrochloride (4), isolated here from a natural source for the first time. In addition, six known compounds tetillapyrone (2), nortetillapyrone (3), 2-methyl maleimide-5-oxime (5), maleimide-5-oxime (6), 5-(hydroxymethyl) dihydrofuran-2 (3H)-one (7), and ergosta-5,24 (28)-dien-3-ol (8) were also identified. Most of the isolated compounds exhibited weak cytotoxic activity against HepG-2, Daoy, and HeLa cancer cell lines. Conclusion: This is the first report of the occurrence of the indole and pyrrolidine alkaloids, 1-(1H-indol-2-yloxy) propan-2-ol (1), and the - (1-hydroxyethyl)-3,4-diol hydrochloride (4), in the Red Sea Haliclona sp. Summary: From the Red Sea Haliclona sp. two alkaloids with indole and pyrrolidine nuclei, 1-(1H-indol-2-yloxy) propan-2-ol-(1) and pyrrolidine-(1-hydroxyethyl)-3,4-diol hydrochloride (4) were isolated and fully characterized; in addition to six known compounds (2, 3, 5-8)The absolute configuration and the three-dimension stereo-molecular structure of compound 4 were determined by X-ray crystallographyThe different extracts and isolated compounds showed weak cytotoxic activity against HepG-2, Daoy, and HeLa cancer cell lines.
    Mar Drugs . 2007 Jun 25;5(2):40-51.
    Antifungal activity evaluation of the constituents of Haliclona baeri and Haliclona cymaeformis, collected from the Gulf of Thailand[Pubmed: 18463723]
    A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1288 mL 20.6441 mL 41.2882 mL 82.5764 mL 103.2205 mL
    5 mM 0.8258 mL 4.1288 mL 8.2576 mL 16.5153 mL 20.6441 mL
    10 mM 0.4129 mL 2.0644 mL 4.1288 mL 8.2576 mL 10.322 mL
    50 mM 0.0826 mL 0.4129 mL 0.8258 mL 1.6515 mL 2.0644 mL
    100 mM 0.0413 mL 0.2064 mL 0.4129 mL 0.8258 mL 1.0322 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    连翘酸; Rengynic acid CFN98829 517883-38-4 C8H14O4 = 174.2 5mg QQ客服:3257982914
    3-(羟基甲基)环戊醇; 3-(Hydroxymethyl)cyclopentanol CFN99022 1007125-14-5 C6H12O2 = 116.2 5mg QQ客服:215959384
    3-(羟基甲基)环戊酮; 3-(hydroxymethyl)cyclopentanone CFN99235 113681-11-1 C6H10O2 = 114.1 5mg QQ客服:2056216494
    3,4-二氢-3,4-二羟基萘-1(2H)-酮; 3,4-Dihydro-3,4-dihydroxynaphthalen-1(2H)-one CFN99338 1220891-22-4 C10H10O3 = 178.2 5mg QQ客服:1413575084
    蔡醇酮; Isoshinanolone CFN91988 39626-91-0 C11H12O3 = 192.21 5mg QQ客服:3257982914
    Tetillapyrone; Tetillapyrone CFN95404 363136-43-0 C11H14O6 = 242.2 5mg QQ客服:3257982914
    广藿香酮; Pogostone CFN90555 23800-56-8 C12H16O4 = 224.26 20mg QQ客服:3257982914
    Phellolactone; Phellolactone CFN92554 1190897-23-4 C13H14O8 = 298.3 5mg QQ客服:2159513211
    6-甲基-5,6-二氢-2H-吡喃-2-酮; 6-Methyl-5,6-dihydropyran-2-one CFN92589 108-54-3 C6H8O2 = 112.1 5mg QQ客服:2056216494
    1,6-二噁螺[4.5]-2-癸醇; 1,6-Dioxaspiro[4.5]decan-2-methanol CFN97320 83015-88-7 C9H16O3 = 172.2 5mg QQ客服:215959384

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