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  • 野漆树苷


    产品编号 CFN99814
    CAS编号 17306-46-6
    分子式 = 分子量 C27H30O14 = 578.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Turpinia arguya Seem.
    产品名称 产品编号 CAS编号 包装 QQ客服
    野漆树苷 CFN99814 17306-46-6 10mg QQ客服:1413575084
    野漆树苷 CFN99814 17306-46-6 20mg QQ客服:1413575084
    野漆树苷 CFN99814 17306-46-6 50mg QQ客服:1413575084
    野漆树苷 CFN99814 17306-46-6 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Chang Gung University (Taiwan)
  • Ateneo de Manila University (Philippines)
  • University of Toulouse (France)
  • Sri Ramachandra University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • National Cancer Institute (USA)
  • Michigan State University (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Mahidol University (Thailand)
  • Chiang Mai University (Thailand)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Max-Planck-Insitut (Germany)
  • Kyushu University (Japan)
  • Seoul National University (Korea)
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  • Oxid Med Cell Longev.2020, 2020:8887251.
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  • Oncol Rep.2021, 46(1):143.
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  • ...
  • 生物活性
    Description: Rhoifolin possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects, it may be beneficial for diabetic complications through its enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Rhoifolin has a radioprotective effect against radiation-induced decrease of blood platelets and cardiac biochemical lesions in whole body irradiated mice.
    Targets: GLUT | TNF-α | PGE | SOD
    In vitro:
    Evid Based Complement Alternat Med. 2011;2011:624375.
    Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.[Pubmed: 20008903]
    Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds.
    Two flavone glycosides, rhoifolin and cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for rhoifolin (1.1%, w/w). In differentiated 3T3-L1 adipocytes, rhoifolin and cosmosiin showed dose-dependent response in concentration range of o.oo1-5 μM and 1-20 μM, respectively, in biological studies beneficial to diabetes. Particularly, rhoifolin and cosmosiin at 0.5 and 20 μM, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 μM of rhoifolin and 20 μM of cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-β, in addition to their positive effect on GLUT4 translocation.
    These findings indicate that rhoifolin and cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
    Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3094-101.
    [Chemical constituents from Callicarpa nudiflora and their cytotoxic activities].[Pubmed: 25509294]
    The chemical consitituents from cytotoxic fraction of the Callicarpa nudiflora extract were isolated and purified by a combination of HP-20 macroporous resin, silica gel and Sephadex LH-20 column chromatographies.
    The structures were elucidated on the basis of the spectroscopic data and comparison of their spectroscopic data with reported data. The cytotoxicity was evaluated by the MTT assay. The 50% and 70% EtOH elutions of EtOH-extract showed significant cytotoxic activities, leading to the isolation of twelve compounds, which were identified as luteoloside(1), lutedin-4'-O-β-D-glucoside(2), 6-hydroxyluteolin-7-O-β-glucoside(3), lutedin-7-O-neohesperidoside(4), rhoifolin (5), luteolin-7, 4'-di-O-glucoside (6), forsythoside B (7), acteoside (8), alyssonoside (9), catalpol(10), nudifloside(11), and leonuride(12). Compounds 3-6, 10 and 12 were isolated from this genus for the first time, and compound 9 was isolated from this plant for the first time. The cytotoxicity assay demonstrated that flavonoids 1-6, in various concentrations, showed monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines. Compounds 3, 5 and iridoid glycoside 11 possessed higher cytotoxicacivities.
    In short, flavonoids are the main components of cytotoxic extract from C. nudiflora, while phenylethanoid glycosides are the predominant ingredient but inactive to cancer cell lines. In addition, the minor iridoid glycoside expressed weak cytotoxic activity.
    Pharmacology & Clinics of Chinese Materia Medica, 2012(6):18-20.
    Study on the protective effect of rhoifolin against hepatic injury induced by triptolide[Reference: WebLink]
    Study on the protective effect of rhoifolin against hepatic injury induced by triptolide.
    The protective effects of rhoifolin at the concentration of 75,150,300μg/ml,on the in vitro damage of human L02 liver cells injured by triptolide at the concentration of 40μg/ml were evaluated with cell survival rates,which were determined by MTT assay.Sixty mice were randomly divided into six groups as follows: The drug groups mice were treated with rhoifolin for six day at the dose of 140,70,35mg/kg,respectively.The normal control group and the model control group took equivalent amount of distilled water by the same route.And mice in the positive control group were treated with 70mg/kg diammonium glycyrrhizinate.After the last administration,all groups except the normal control were administered with triptolide at dose of 0.625mg/kg by gavage to induce acute hepatic injury.Thereafter,the contents of ALT,AST in serum,the activities of SOD,MDA,GSH-Px and GST in the liver were measured and the hepatic histological changes were observed by optical microscope. The cell survival rates of human L02 liver cells injured by triptolide and then treated with rhoifolin at the concentration of 75,150,300μg/ml were significantly increased.The contents of ALT,AST in serum were significantly decreased,the content of MDA in the liver was also significantly lowered,and the activities of SOD,MDA,GSH-Px and GST in liver were significantly improved after preventive treatment with rhoifolin at the dose of 140,70,35mg/kg.Rhoifolin can ameliorated the hepatic pathological changes.
    The protective effect of rhoifolin against hepatic injury induced by triptolide was significant in vitro and in vivo.
    In vivo:
    J. Appl. Pharmaceut. Sci., 2012, 2(8):74-9.
    Anti-inflammatory effect of Apigenin-7-neohesperidoside (Rhoifolin) in carrageenin-induced rat edema model[Reference: WebLink]
    Flavonoids are normal constituents of the human diet and are known for a variety of biological activities. They have been reported to bring benefits in lowering inflammation and oxidative stress.
    The present investigation was performed first, to evaluate the anti-inflammatory activity of Rhoifolin and second, to search for the possible contributing mechanisms for this hypothesized effect. Rhoifolin caused a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema. Following 4 hr of treatment, Rhoifolin at doses 2.5, 25 & 250 mg/kg caused a significant inhibition of rat paw edema volume by 14, 25 & 45 % respectively in comparison to the control group (74%). In addition to significantly abrogating prostaglandin E2 level, increasing doses of Rhoifolin significantly diminished the TNF-a release in the inflammatory exudates. In the same animal model, Rhoifolin increased the total antioxidant capacity in a reverse dose order, with the highest capacity obtained with the lowest dose tested.
    This study demonstrates for the first time the effectiveness.
    J Cell Physiol . 2019 Aug;234(10):17600-17611.
    Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways[Pubmed: 30854667]
    Abstract Prosthesis loosening is a highly troublesome clinical problem following total joint arthroplasty. Wear-particle-induced osteoclastogenesis has been shown to be the primary cause of periprosthetic osteolysis that eventually leads to aseptic prosthesis loosening. Therefore, inhibiting osteoclastogenesis is a promising strategy to control periprosthetic osteolysis. The possible mechanism of action of rhoifolin on osteoclastogenesis and titanium particle-induced calvarial osteolysis was examined in this study. The in vitro study showed that rhoifolin could strongly suppress the receptor activators of nuclear factor-κB (NF-κB) ligand-stimulated osteoclastogenesis, hydroxyapatite resorption, F-actin formation, and the gene expression of osteoclast-related genes. Western blot analysis illustrated that rhoifolin could attenuate the NF-κB and mitogen-activated protein kinase pathways, and the expression of transcriptional factors nuclear factor of activated T cells 1 (NFATc1) and c-Fos. Further studies indicated that rhoifolin inhibited p65 translocation to the nucleus and the activity of NFATc1 and NF-κB rhoifolin could decrease the number of tartrate-resistant acid phosphate-positive osteoclasts and titanium particle-induced C57 mouse calvarial bone loss in vivo. In conclusion, our results suggest that rhoifolin can ameliorate the osteoclasts-stimulated osteolysis, and may be a potential agent for the treatment of prosthesis loosening. Keywords: RANKL; osteoclast; rhoifolin; titanium particle.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7286 mL 8.643 mL 17.2861 mL 34.5722 mL 43.2152 mL
    5 mM 0.3457 mL 1.7286 mL 3.4572 mL 6.9144 mL 8.643 mL
    10 mM 0.1729 mL 0.8643 mL 1.7286 mL 3.4572 mL 4.3215 mL
    50 mM 0.0346 mL 0.1729 mL 0.3457 mL 0.6914 mL 0.8643 mL
    100 mM 0.0173 mL 0.0864 mL 0.1729 mL 0.3457 mL 0.4322 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芹菜素-7-O-葡萄糖醛酸甲酯苷; Apigenin 7-O-methylglucuronide CFN98894 53538-13-9 C22H20O11 = 460.4 5mg QQ客服:3257982914
    5-O-beta-D-吡喃葡萄糖苷芹菜甙元; Apigenin 5-O-beta-D-glucopyranoside CFN98352 28757-27-9 C21H20O10 = 432.4 10mg QQ客服:3257982914
    芹菜苷; Apiin CFN90165 26544-34-3 C26H28O14 = 564.49 20mg QQ客服:3257982914
    芹菜素 7-[鼠李糖-(1->2)-半乳糖醛酸苷]; Apigenin 7-[rhamnosyl-(1->2)-galacturonide] CFN95352 124167-97-1 C27H28O15 = 592.5 10mg QQ客服:1413575084
    芹菜素 7-二葡萄糖苷酸; Apigenin 7-diglucuronide CFN91599 74696-01-8 C27H26O17 = 622.5 5mg QQ客服:1457312923
    野漆树苷类似物; New compound 12 (Rhoifolin analog) CFN95371 N/A C33H38O18 = 722.7 5mg QQ客服:215959384
    野漆树苷; Rhoifolin CFN99814 17306-46-6 C27H30O14 = 578.5 20mg QQ客服:2159513211
    异野漆树苷; Isorhoifolin CFN98927 552-57-8 C27H30O14 = 578.5 5mg QQ客服:215959384
    女贞苷; Ligustroflavone CFN90224 260413-62-5 C33H40O18 = 724.67 20mg QQ客服:215959384
    芹菜素-7-0-(2G-鼠李糖)龙胆糖苷; Apigenin 7-O-(2G-rhamnosyl)gentiobioside CFN90671 174284-20-9 C33H40O19 = 740.67 20mg QQ客服:2159513211





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