王百合苷I

Regaloside I

	产品编号	CFN95525
	CAS编号	126239-78-9
	分子式 = 分子量	C₂₀H₂₆O₁₁ = 442.4
	产品纯度	>=98%
	物理属性	Solid
	化合物类型	Phenols
	植物来源	The rhizomes of Lilium brownii var. viridulum Baker
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
王百合苷I	CFN95525	126239-78-9	1mg	QQ客服：2159513211
王百合苷I	CFN95525	126239-78-9	5mg	QQ客服：2159513211
王百合苷I	CFN95525	126239-78-9	10mg	QQ客服：2159513211
王百合苷I	CFN95525	126239-78-9	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Description:

Regaloside I, which has the structure of phenylpropanolglycerol glycoside, acts as an active compound that inhibits the upregulation of CAPZA1 and inhibits UVA-induced changes in HDF shape, which in turn inhibits collagen reduction.

In vitro:

Exp Dermatol . 2016 Aug;25 Suppl 3:45-51.

Morphological change of skin fibroblasts induced by UV Irradiation is involved in photoaging[Pubmed: 27539902]

Human dermal fibroblasts (HDFs) are typically flattened or extensible shaped and play a critical role in the metabolism of extracellular matrix components. As the properties of fibroblasts in the dermis are considered to be influenced by their morphology, we investigated the morphological changes induced in fibroblasts by ultraviolet (UV) irradiation as well as the relationship between these changes and collagen metabolism. In this study, we showed that UVA exposure induced morphological changes and reduced collagen contents in HDFs. These morphological changes were accompanied a reduction in actin filaments and upregulation of the actin filament polymerization inhibitor, capping protein muscle Z-line ɑ1 (CAPZA1). External actin filament growth inhibitors also affected the shape of HDFs and reduced collagen levels. These results suggest that UVA exposure may inhibit the polymerization of actin filaments and induce morphological changes in skin fibroblasts. These morphological changes in fibroblasts may accelerate reductions in collagen synthesis. This mechanism may be one of the processes responsible for collagen reductions observed in photoaged skin. When natural materials that suppress these morphological changes in HDFs were evaluated, we found that an extract of Lilium 'Casa Blanca' (LCB) suppressed UVA-induced alterations in the shape of HDFs, which are typically followed by inhibition of collagen reduction. An analysis of the active compounds in LCB extract led to the identification of regaloside I, which had a structure of phenylpropanoid glycerol glucoside, as the active compound inhibiting the upregulation of CAPZA1. Therefore, inhibition of UVA-induced morphological changes in HDFs is considered to be promising way for the suppression of collagen reduction in photoaging.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
王百合苷A; Regaloside A	CFN91852	114420-66-5	C₁₈H₂₄O₁₀ = 400.4	10mg	QQ客服：2056216494
王百合苷B; Regaloside B	CFN91844	114420-67-6	C₂₀H₂₆O₁₁ = 442.4	20mg	QQ客服：1413575084
王百合苷C; Regaloside C	CFN91843	117591-85-2	C₁₈H₂₄O₁₁ = 416.4	10mg	QQ客服：2056216494
王百合苷D; Regaloside D	CFN91842	120601-66-3	C₁₈H₂₄O₁₀ = 400.4	5mg	QQ客服：215959384
王百合苷F; Regaloside F	CFN91798	120601-65-2	C₁₉H₂₆O₁₁ = 430.40	5mg	QQ客服：2159513211
王百合苷H; Regaloside H	CFN91799	126239-77-8	C₁₈H₂₄O₁₀ = 400.38	5mg	QQ客服：3257982914
王百合苷I; Regaloside I	CFN95525	126239-78-9	C₂₀H₂₆O₁₁ = 442.4	5mg	QQ客服：1457312923
Oblongaroside B; Oblongaroside B	CFN95543	1000889-11-1	C₂₀H₂₆O₁₀ = 426.4	10mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2604 mL	11.302 mL	22.604 mL	45.208 mL	56.5099 mL
5 mM	0.4521 mL	2.2604 mL	4.5208 mL	9.0416 mL	11.302 mL
10 mM	0.226 mL	1.1302 mL	2.2604 mL	4.5208 mL	5.651 mL
50 mM	0.0452 mL	0.226 mL	0.4521 mL	0.9042 mL	1.1302 mL
100 mM	0.0226 mL	0.113 mL	0.226 mL	0.4521 mL	0.5651 mL